Fibrin sealing versus stapling of hernia meshes in an onlay model in the rat

Abstract

Incisional and inguinal hernia repair are among the most common procedures of general surgery. Mesh fixation by means of staples or sutures may lead to severe complications. The use of fibrin sealant (FS) has been suggested as alternative, but data on biocompatibility and adhesive strength of FS in combination with macroporous meshes is limited. Ventral hernia (n = 8 per group) was treated in rats in onlay technique with two types of meshes, fibrin sealed or stapled. TI-Mesh (TMxl) extralight and VYPROII (VPII) were tested 17 days post op. No failure in mechanical tests (tensile and burst strength) occurred in sealed or stapled meshes. Histology revealed equally good tissue integration and neovascularization in all groups. Fibrin sealant yields excellent fixation in experimental hernia repair. This rat model is suitable for testing meshes and fixation techniques.

Do collagen meshes offer any benefits over preclude® ePTFE implants in contaminated surgical fields? A comparative in vitro and in vivo study

“…[19][20][21] Our results support those reported by other authors 22 in that no collagen-derived material has shown intrinsic antimicrobial activity. Neither were we able to observe inhibition halos around the biomeshes when cultured in the presence of Sa and Se.…”

Primary mesh augmentation with fibrin glue for abdominal wall closure—investigations on a biomechanical model

“…Mesh fixation with fibrin glue is a quick and reliable method, as borne out not only by the biomechanical results of our tests [35,36]. While it was not possible to obtain essentially higher tensile strength values for suture reinforcement with fibrin glue alone, the specified retention force value was significantly exceeded through the additional use of a mesh.…”

“…But, once again, the question arises as to how such meshes are to be fixed so that they can assume an effective prophylactic role. By means of other models of hernia repair, it was possible to demonstrate that mesh fixation with fibrin glue could be equated with sutureor staples-based fixation [35][36][37] and that this could even expedite mesh integration into the surrounding tissue.…”

Tissue resistance of the tension-free procedure: What about healing?

“…However, it is the first time such a study has been done, and it could be useful if extrapolation to humans proves possible. We will also have to study the influence of the size of the meshes, their structure, the materials used, and the use of biological glues to enhance resistance [15,16].…”