2021
DOI: 10.3390/cancers13092056
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Fibrin Sealants and Axillary Lymphatic Morbidity: A Systematic Review and Meta-Analysis of 23 Clinical Randomized Trials

Abstract: Background: use of fibrin sealants following pelvic, paraaortic, and inguinal lymphadenectomy may reduce lymphatic morbidity. The aim of this meta-analysis is to evaluate if this finding applies to the axillary lymphadenectomy. Methods: randomized trials evaluating the efficacy of fibrin sealants in reducing axillary lymphatic complications were included. Lymphocele, drainage output, surgical-site complications, and hospital stay were considered as outcomes. Results: twenty-three randomized studies, including … Show more

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Cited by 4 publications
(2 citation statements)
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“…Fibrin sealants are among the most prevalent technologies in the surgical toolbox, and, after more than a century of research, it is becoming increasingly clear that there is no universal sealant composition that matches all criteria relating to hemostatic or sealing efficacy, adequate adhesion, biosafety, cost effectiveness and ease of application. This is also reflected by recent meta‐analyses showing that positive effects of fibrin sealants on patient outcomes vary considerably depending on the fibrin sealant system used and the surgical setting 22,58–60 . Previous studies have focused on the clinical evaluation of fibrin sealants versus other natural or synthetic sealant systems, while comparative data, both clinical and non‐clinical, on individual products within the fibrin sealant class are still scarce.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Fibrin sealants are among the most prevalent technologies in the surgical toolbox, and, after more than a century of research, it is becoming increasingly clear that there is no universal sealant composition that matches all criteria relating to hemostatic or sealing efficacy, adequate adhesion, biosafety, cost effectiveness and ease of application. This is also reflected by recent meta‐analyses showing that positive effects of fibrin sealants on patient outcomes vary considerably depending on the fibrin sealant system used and the surgical setting 22,58–60 . Previous studies have focused on the clinical evaluation of fibrin sealants versus other natural or synthetic sealant systems, while comparative data, both clinical and non‐clinical, on individual products within the fibrin sealant class are still scarce.…”
Section: Discussionmentioning
confidence: 99%
“…This is also reflected by recent meta‐analyses showing that positive effects of fibrin sealants on patient outcomes vary considerably depending on the fibrin sealant system used and the surgical setting. 22 , 58 , 59 , 60 Previous studies have focused on the clinical evaluation of fibrin sealants versus other natural or synthetic sealant systems, while comparative data, both clinical and non‐clinical, on individual products within the fibrin sealant class are still scarce. We thus sought to analyze in detail the overall physicochemical properties of two fibrin sealants, FS and FS+Osm, which have both been successfully used in clinics.…”
Section: Discussionmentioning
confidence: 99%