Fibrin Glue Used as an Adhesive Agent in CNS Tissues

Cheng, Henrich; Almström, Susanne; Olson, Lar̀s

doi:10.1155/np.1994.233

Cited by 27 publications

(12 citation statements)

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“…Delivered in this form, FK506 increases both the rate and extent of axon regeneration [357]. FK506 also reduces by half the time to achieve neurological recovery, although it does not induce a significant improvement of long-term neurological recovery compared to control animals [358,359].…”

Section: Immunosuppressantsmentioning

confidence: 99%

“…Thus, the simultaneous administration of FK506, NGF and bFGF within a nerve conduit bridging a nerve gap leads to axons regenerating longer distances than when these factors are administered alone [358,[361][362][363][364].…”

Section: Immunosuppressantsmentioning

confidence: 99%

“…This is because the Schwann cells of such nerves no longer synthesize and release the neurotrophic factors that are required to promote axon regeneration . However, the administration of FK506 increases the number of axons that regenerate into and though chronically denervated nerves [358]. This is best explained by explained by results showing that the FK506 derivative, jnj460, acts on Schwann cells altering their gene expression causing them to release factors that promote neurite outgrowth from DRG neurons in vitro .…”

Section: Immunosuppressantsmentioning

confidence: 99%

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Promoting Axon Regeneration and Neurological Recovery Following Traumatic Peripheral Nerve Injuries

Kuffler¹

2015

Int J Neurorehabilitation Eng

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Repairing Peripheral Nerves following Traumas Nerve crushWithin several days of crushing a peripheral nerve, the injured axons begin to regenerate through their distal pathway until they reach their original targets with which they restore neurological function. The larger the number of axons that regenerate through the distal nerve, the greater the extent of neurological recovery [1][2][3]. The number of axons that regenerate, and thus neurological recovery, is influenced by the physiological state of the distal denervated nerve pathway [4][5][6][7].Following a peripheral nerve crush, the injured axons begin to regenerate within 2 days of injury [8]. They may regenerate to their targets through their original pathway in association with and promoted by its Schwann cells, the neurotrophic factors they release, and the Schwann cell extracellular matrix [1,4,[9][10][11][12][13][14]. Thus, the distal nerve provides a simple means for promoting and directing the regenerating axons to their original targets [15][16][17][18]. However, when a nerve has a gap, the gap must be bridged with a material that is permissive to and promotes axon regeneration across the entire gap to reach the distal nerve stump, through which the axons must then be able to regenerate.The Schwann cells in the denervated distal nerve release neurotrophic factors that promote axon regeneration, but also release extracellular matrix components that promote and inhibit axon regeneration [19][20][21][22][23][24][25][26]. Thus, regeneration through the distal nerve is a balance of the influences of factors that both promote and inhibit regeneration. If the Schwann cells are present, such as after a simple nerve crush, virtually 100% of the axons regenerate and they innervate all the denervated synaptic sites. If the Schwann cells within the distal nerve pathway are killed, leaving only the extracellular matrix intact, the number of axons that regenerates to their targets decreases by 94%. This is because the factors required to trigger the regenerating axons to branch at extracellular matrix branch points are missing, axons do not branch, and therefore each axon reinnervates only a single denervated muscle fiber. Thus, Schwann cells along the distal nerve pathway and a AbstractFollowing a peripheral nerve crush, or when a peripheral the nerve is transected and the nerve stumps anastomosed, neurological recovery is generally excellent. This is because the axons merely have to regenerate through the distal portion of the nerve through the existing extracellular matrix of the denervated Schwann cells that direct and promote them to their distant denervated motor and sensory targets. However, when a length of a peripheral nerve is destroyed, and anastomosis is not possible, the standard surgical repair technique is to graft a length/s of autologous sensory nerve into the gap. Neurological recovery is generally good if the nerve gap is <2 cm in length, the repair is performed <4 months post trauma, and the patients are <25 years of age. Because the nerve ...

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Section: Immunosuppressantsmentioning

confidence: 99%

Section: Immunosuppressantsmentioning

confidence: 99%

Section: Immunosuppressantsmentioning

confidence: 99%

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Promoting Axon Regeneration and Neurological Recovery Following Traumatic Peripheral Nerve Injuries

Kuffler¹

2015

Int J Neurorehabilitation Eng

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“…In nasal and functional endoscopic sinus surgery (ESS), the limited surgical field and the need to use minimally invasive procedures make it difficult to use sutures (the gold standard), particularly in mucosal regions (2). Wound closure, skin grafting, and the fixation of transplants and implants are vital to ensure surgical success.…”

Section: Introductionmentioning

confidence: 99%

“…The lamina cribrosa is fragile, and defects and dehiscence can develop from the area of attachment of the median concha to the skull base and in the anterior and posterior ethmoidal artery channels. If an iatrogenic injury leads to cerebrospinal fluid leakage, the fistula can be closed with muscle, bone wax, fascia, a bony plate, a mucoperichondrial flap, a dural flap, tissue glue, or fat tissue (2,3).…”

Section: Introductionmentioning

confidence: 99%

Histopathological Effects of Fibrin Glue and Cyanoacrylate on the Maxillary Sinus

Sarıkaya

Bişkin

Damar

et al. 2016

Turk Arch Otorhinolaryngol

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Objective: To compare the histopathological effects of fibrin glue (FbGl) and cyanoacrylate (CyAc) on the maxillary sinus mucosa.Methods: Twenty rabbits were divided into two groups of 10, and surgical defects were created in the maxillary sinuses. The right maxillary sinus was treated with FbGl in one group and with CyAc in the other group. As a control, the left maxillary sinuses of all rabbits were treated with sterile saline solution. One rabbit treated with CyAc died during the study and was excluded. On postoperative day 21, all animals were sacrificed. Maxillary sinus mucosa samples were studied to determine the extent of inflammation and fibrosis, foreign body reaction, cilia loss, increased osteogenesis in bony structures under the mucosa, and loss of serous glands.

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Functional connectivity of the transected brachial plexus after intercostal neurotization in monkeys

Cheng

Shoung

et al. 1997

J. Comp. Neurol.

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Microsurgical reconstructions of brachial plexuses were performed on twelve monkeys by using ipsilateral intercostal nerves (T3-9). Reinnervation in individual nerves was evaluated monthly by observations of neuromuscular and electromyographic improvements. The electromyographic studies revealed reappearance of motor unit potentials. According to a motor scale ranging from 0 to 4, the mean muscle power 6 months after operation improved to 2.75 in the deltoid muscles, 2 in the biceps muscles, 1.22 in the triceps muscles, 1.13 in the flexor carpi radialis muscles, and 1.6 in the intrinsic muscles of the hands. Retrograde transport of horseradish peroxidase (HRP) from the neuromuscular junctions of the reconstructed musculocutaneous nerves 6 months after complete brachial plexus lesion in four animals demonstrated HRP-labeled neurons in the anterior horns, spinal ganglia and sympathetic ganglia of the thoracic spinal cords. It suggested that the regenerated afferent and efferent circuits in the thoracic cords innervating the transected brachial plexuses were able to generate the movements in the paralyzed upper limbs. However, as evidenced by the behavior patterns and the fact that retrograde-labeled neurons were all found in the thoracic cords, the novel movements observed in the reconstructed brachial plexuses were in synchrony with respiration. These results suggested that the plasticity of central neural networks is limited between two widely separated areas, such as between the midcervical and midthoracic motor cortical areas in the present studies, and therefore, the efforts to reconstruct neural networks, both centrally and peripherally, should aim at rebuilding situations as nearly to the original status as possible.

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Fibrin Glue Used as an Adhesive Agent in CNS Tissues

Cited by 27 publications

References 0 publications

Promoting Axon Regeneration and Neurological Recovery Following Traumatic Peripheral Nerve Injuries

Promoting Axon Regeneration and Neurological Recovery Following Traumatic Peripheral Nerve Injuries

Histopathological Effects of Fibrin Glue and Cyanoacrylate on the Maxillary Sinus

Functional connectivity of the transected brachial plexus after intercostal neurotization in monkeys

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