Fibrin glue instillation under skin flaps to prevent seroma related morbidity following breast and axillary surgery

Sajid, M. S.; Hutson, Kristian; Rapisarda, I.F.; Bonomi, Riccardo

doi:10.1002/14651858.cd009557

Cited by 12 publications

(10 citation statements)

References 51 publications

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“…There has been a meta‐analysis of fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery . There were 18 RCT's reviewed involving 1252 undergoing breast surgery and axillary surgery for breast cancer.…”

Section: Discussionmentioning

confidence: 99%

The use of Tisseel^™ fibrin sealant in selective neck dissection – a retrospective study in a tertiary Head and Neck Surgery centre

Mushi

Kinshuck

Svecova

et al. 2015

Clinical Otolaryngology

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The use of Tisseel in SND resulted in lower drain output and shorter period of drain in situ and hospitalisation. There was no additional morbidity or complication associated with its use, and the initial conclusion is that this technique may have benefits not only to patient recovery but also for healthcare providers as they could potentially reduce the overall costs of surgery by reducing the length of hospital stay.

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Section: Discussionmentioning

confidence: 99%

The use of Tisseel^™ fibrin sealant in selective neck dissection – a retrospective study in a tertiary Head and Neck Surgery centre

Mushi

Kinshuck

Svecova

et al. 2015

Clinical Otolaryngology

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“…One study using the fibrin sealant Tisseel showed that it facilitated drain‐free breast cancer surgery . However, a Cochrane review published in 2013 concluded that there was insufficient evidence to definitively assess the impact of fibrin sealants on seroma rates or seroma volume, complication rate, and length of hospital stay in patients undergoing surgery for breast cancer …”

Section: Introductionmentioning

confidence: 99%

Increasing the incidence of drain‐free day‐case mastectomies with the use of a fibrin tissue sealant; data from a single surgical center in the United Kingdom

et al. 2019

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Day‐case mastectomy surgery provides benefits to both patients and hospitals. Key barriers are the use of a drain and the risk of postoperative seroma formation. We introduced the use of a tissue sealant (Artiss) into the surgical site (post‐mastectomy without immediate reconstruction and postaxillary clearance) and evaluated its effect on our practice, particularly day‐case rates. A prospective audit of 177 patients who underwent a simple mastectomy with or without axillary surgery, or axillary node clearance with or without breast‐conserving surgery was conducted at a single surgical center in the UK between November 2015 and November 2016. Artiss was used in all operations and, where appropriate, the drain was omitted to facilitate day‐case surgery. The clinical outcomes were compared between patients undergoing different operations and duration of hospital stay. There was no statistically significant difference between day‐case patients and inpatients in seroma aspiration rates (24.5% and 21.7%, respectively; P = 0.381) or other complications (22.4% and 16.1%, respectively; P = 0.106). The day‐case mastectomy rate increased from 3.9% in the first quarter to 45.5% in the final quarter, which was a significant increase reaching well beyond the national target. The use of Artiss enabled us to increase the drain‐free day‐case surgery rates over a 1‐year period, exceeding the 30% target recommended by the British Association of Day Surgery. We did not observe any increase in patient morbidity, and the change was cost‐effective. We have now implemented the routine use of Artiss in women undergoing simple mastectomy with or without axillary surgery and stand‐alone axillary node clearances as part of enhanced recovery clinical pathways.

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“…Fibrin sealants (FS) are commercially available and US Food and Drug Administration (FDA)-approved products that have been extensively investigated in recent years within several areas of surgery. 1 However, results have been variable and often unduly influenced by poor study design. FS is applied to the raw surfaces of the surgical wound prior to closure and considered to be an adjunct to haemostasis.…”

Section: Introductionmentioning

confidence: 99%

Fibrin sealants in soft tissue surgery of the head and neck: A systematic review and meta‐analysis of randomised controlled trials

Bajwa

Tudur-Smith

Shaw

et al. 2017

Clinical Otolaryngology

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Fibrin glue instillation under skin flaps to prevent seroma related morbidity following breast and axillary surgery

Cited by 12 publications

References 51 publications

The use of Tisseel^™ fibrin sealant in selective neck dissection – a retrospective study in a tertiary Head and Neck Surgery centre

The use of Tisseel^™ fibrin sealant in selective neck dissection – a retrospective study in a tertiary Head and Neck Surgery centre

Increasing the incidence of drain‐free day‐case mastectomies with the use of a fibrin tissue sealant; data from a single surgical center in the United Kingdom

Fibrin sealants in soft tissue surgery of the head and neck: A systematic review and meta‐analysis of randomised controlled trials

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Fibrin glue instillation under skin flaps to prevent seroma related morbidity following breast and axillary surgery

Cited by 12 publications

References 51 publications

The use of Tisseel™ fibrin sealant in selective neck dissection – a retrospective study in a tertiary Head and Neck Surgery centre

The use of Tisseel™ fibrin sealant in selective neck dissection – a retrospective study in a tertiary Head and Neck Surgery centre

Increasing the incidence of drain‐free day‐case mastectomies with the use of a fibrin tissue sealant; data from a single surgical center in the United Kingdom

Fibrin sealants in soft tissue surgery of the head and neck: A systematic review and meta‐analysis of randomised controlled trials

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The use of Tisseel^™ fibrin sealant in selective neck dissection – a retrospective study in a tertiary Head and Neck Surgery centre

The use of Tisseel^™ fibrin sealant in selective neck dissection – a retrospective study in a tertiary Head and Neck Surgery centre