Fibrin Glue Inhibits Intra-abdominal Adhesion Formation

Virgilio, Christian de; Dubrow, Terry J.; Sheppard, Barry; MacDonald, W. D.; Nelson, Ronald J.; Lesavoy, Malcolm A.; Robertson, John M.

doi:10.1001/archsurg.1990.01410220162023

Cited by 64 publications

(31 citation statements)

References 6 publications

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“…Some hemostatic agents such as cyanoacrylate [28] and albumin-glutaraldehyde adhesives [29] have been reported to cause foreign body reaction and inflammation and promote adhesion formation. Meanwhile, fibrin glue has been reported to form an intra-abdominal adhesion after surgery equal to or less than no treatment [29, 30]. Moreover, some studies showed that fibrin glue more effectively reduced the severity of postoperative adhesion than the conventional suture technique in liver injury animal models [9, 10].…”

Section: Discussionmentioning

confidence: 99%

Hemostatic Efficacy and Safety of the Novel Medical Adhesive, MAR VIVO-107, in a Rabbit Liver Resection Model

et al. 2018

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Background: Topical hemostatic agents are useful when hepatic hemorrhage is difficult to control. The aim of this study was to evaluate the hemostatic efficacy and safety of a biodegradable polyurethane-based adhesive, MAR VIVO-107 (MAR), in comparison with a clinically used fibrin glue. Methods: Thirty female New Zealand white rabbits were randomly assigned to 3 study groups as follows: MAR (n = 10), fibrin glue (n = 10), and saline groups (n = 10). After standardized partial liver resection was performed, each agent was immediately applied to the wound area. Bleeding time until hemostasis and blood loss were recorded. After 7 days, body weight, hematology parameters, and serum levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase were measured. Simultaneously, the severity of intra-abdominal adhesion was evaluated. Results: The mean bleeding time in the MAR (38 ± 10 s) and fibrin glue groups (65 ± 17 s) was significantly shorter than that in the saline group (186 ± 12 s). Similarly, the mean blood loss in the MAR (9 ± 3 g) and fibrin glue groups (9 ± 3 g) was significantly less than that in the saline group (23 ± 4 g). No significant differences in bleeding time and blood loss were found between the MAR and fibrin glue groups. The postoperative survival rate was 100% in all the groups. Body weight as well as hematological and serum biochemical values on day 7 were within the small and physiological range when compared with the preoperative baseline values, and significant differences were not detected among the MAR, fibrin glue, and saline groups. The severities of adhesion were similar between the 3 groups. Conclusion: Our data demonstrated that MAR was not inferior to fibrin glue in terms of hemostatic efficacy and safety.

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Section: Discussionmentioning

confidence: 99%

Hemostatic Efficacy and Safety of the Novel Medical Adhesive, MAR VIVO-107, in a Rabbit Liver Resection Model

et al. 2018

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“…Fibrin glue has been found to be e ective for the prevention of intra-abdominal adhesions [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Histopathological effects of fibrin glue on penile fracture in a rat model

Taşdemir

Şamdancı²,

Turtay³

et al. 2011

CIM

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“…Fibrin glue can be used effectively for ovarian reconstruction and is a good means to completely avoid sutures. Although there are some reported animal studies in which fibrin glue inhibits intra-abdominal adhesion formation [4,5], Gauwerky et al [9] could not find any significant difference between covering the peritoneal defects with fibrin glue and not doing so.…”

Section: Discussionmentioning

confidence: 96%

“…Postoperative adhesions following wedge resection for polycystic ovaries might impair fertility in up to one third of cases [1], An improved surgical tech nique in ovarian closure might decrease adhesion forma tion and result in higher fertility rates. Concentrated human fibrin glue is recommended for adherence in tubal surgery and bowel anastomosis [2,3], and there are some reports indicating inhibition of intra-abdominal adhe sions using this glue [4,5], In our opinion, postoperative adhesion formation following different ovarian recon struction techniques including fibrin glue has not been studied thoroughly. We, therefore, decided to study the role of fibrin glue in ovarian surgery and compare it with the classical microsurgical technique in the rabbit.…”

Section: Introductionmentioning

confidence: 99%

Postoperative Adhesion Formation following Ovarian Reconstruction with Fibrin Glue in the Rabbit

Bilgin¹,

Cengiz²,

Demir³

1995

Gynecol Obstet Invest

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To compare postoperative adhesion formation following ovarian reconstruc tion with fibrin glue or the microsurgical suturing technique, an experimental study was performed on sixteen adult female rabbits. While left ovaries were reapproximated with 6-0 coated polyglactin using a microsurgical technique, right ovaries were reconstructed with fibrin glue following ovarian bisection. Four weeks later, second-look laparotomies were performed to evaluate the adnexal adhesions. These were scored according to the American Fertility Society classification. Mean adnexal adhesion scores were 8.2 ± 2.3 in the sutured ovary and 5.0 ± 1.1 in the glued ovary (p > 0.05). Ovarian reconstruc tion with fibrin glue does not reduce postoperative adhesion when compared with the usual suturing technique.

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Fibrin Glue Inhibits Intra-abdominal Adhesion Formation

Cited by 64 publications

References 6 publications

Hemostatic Efficacy and Safety of the Novel Medical Adhesive, MAR VIVO-107, in a Rabbit Liver Resection Model

Hemostatic Efficacy and Safety of the Novel Medical Adhesive, MAR VIVO-107, in a Rabbit Liver Resection Model

Histopathological effects of fibrin glue on penile fracture in a rat model

Postoperative Adhesion Formation following Ovarian Reconstruction with Fibrin Glue in the Rabbit

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