Fibrin glue in the management of anal fistulae

Hammond, T; Grahn, Michael F.; Lunniss, Peter J.

doi:10.1111/j.1463-1318.2004.00676.x

Cited by 110 publications

(71 citation statements)

References 51 publications

(145 reference statements)

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“…It had been suggested in the past, that suturing of the internal opening prevented the expulsion of the clot, but various recent trials [10][11][12][13][14][15] have proved that there was no significant change in the healing rate, with this procedure. Nine out of these 10 recurrences (90%), were reported in the first 3 months of the follow up.…”

Section: Resultsmentioning

confidence: 99%

The Role of Fibrin Glue in the Treatment of High and Low Fistulas in Ano

Mishra¹

2013

JCDR

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Section: Resultsmentioning

confidence: 99%

The Role of Fibrin Glue in the Treatment of High and Low Fistulas in Ano

Mishra¹

2013

JCDR

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“…This treatment modality is appealing because it carries no risk of incontinence associated with division of sphincter muscles. It is safe and easy to perform, avoids open perineal wounds, and does not interfere with future surgical treatments if necessary (10,14) . The efficacy of the fibrin glue injection, however, remains in question.…”

Section: Discussionmentioning

confidence: 99%

“…The procedure is very easy to perform, has no significant morbidity and preserves continence without compromising future surgical treatments (6) . However, the success rates of the fibrin glue injection have range from 0%-100% (10) . Such a wide variation seems to result from differences in the etiology and complexity of the fistulas included in each series, as well as from variable sample sizes and duration of patient follow-up (10,20) .…”

Section: Introductionmentioning

confidence: 99%

“…However, the success rates of the fibrin glue injection have range from 0%-100% (10) . Such a wide variation seems to result from differences in the etiology and complexity of the fistulas included in each series, as well as from variable sample sizes and duration of patient follow-up (10,20) . In the present study, we evaluate the efficacy of the fibrin glue treatment in patients with complex cryptoglandular anal fistulas.…”

Section: Introductionmentioning

confidence: 99%

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Fibrin glue in the management of complex anal fistula

Damin

Rosito

Contu

et al. 2009

Arq. Gastroenterol.

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-Context -Management of complex anal fistulas is associated with the risk of sphincter injury and fecal incontinence.In recent years, fibrin glue has emerged as an alternative sphincter-preserving treatment for anal fistulas. To date, however, there is no consensus about the efficacy of the method. Objective -To specifically evaluate the fibrin glue injection in the management of complex cryptoglandular anal fistulas. Methods -We studied a series of patients with complex anal fistulas treated with fibrin glue between January 2005 and January 2007. Only patients with fistulas of cryptoglandular origin were analyzed. Patients with fistulas related to Crohn's disease, HIV or previous surgery were excluded from the study. Under spinal anesthesia, the fistulas were curetted and injected with fibrin glue. After treatment, patients were followed-up for 12 months. Results -Thirty-two patients were enrolled in the study. Two patients were lost to follow-up and were excluded. Out of the remaining 30 patients, only three healed successfully (10%). Among the 27 patients who failed to heal, 9 (33.3%) were diagnosed within the first postoperative month. In 13 patients (48.1%) the failure of treatment occurred in the period between 1 and 3 months, in 3 patients (11.1%) between 3 and 6 months, and in 2 patients (7.4%) between 6 and 9 months after surgery. No treatment-related complications were observed. Conclusions -In this series, fibrin glue treatment for complex cryptoglandular anal fistulas achieved a very low healing rate. Our results do not support the use of fibrin glue as a first-line treatment for patients with this type of fistula. HEADINGS -Rectal fistula. Fibrin tissue adhesive. Tissue adhesives.

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“…Apesar dessas discrepâncias metodológicas, pode-se concluir que o método é de fácil execução, com mínimas complicações e não afeta as opções de tratamento posteriores, em caso de insucesso do método. Pode ser, portanto, uma opção atrativa como primeiro método de tratamento de fístulas anais 4 .…”

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O emprego da cola de fibrina no tratamento das fístulas anais

Lopes-Paulo

2006

Rev bras. colo-proctol.

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O emprego de cola de fibrina no tratamento de fístulas anais tem sido relatado em diversos estudos, com a finalidade de obliterar o trajeto fistuloso, criando uma matriz para sua cicatrização definitiva. O método consiste na curetagem e lavagem do trajeto fistuloso, seguidas pela injeção da cola. Esse procedimento pode ser associado ao avanço de retalhos endorretais ou outros métodos para obliteração do orifício interno, o que pode aumentar sua eficácia. Os índices de cicatrização descritos variam de 30 a 50 % em média. A sua utilização não prejudica a realização de outros procedimentos, em caso de insucesso, o que pode torná-lo uma opção para o tratamento inicial das fístulas anais.

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Fibrin glue in the management of anal fistulae

Cited by 110 publications

References 51 publications

The Role of Fibrin Glue in the Treatment of High and Low Fistulas in Ano

The Role of Fibrin Glue in the Treatment of High and Low Fistulas in Ano

Fibrin glue in the management of complex anal fistula

O emprego da cola de fibrina no tratamento das fístulas anais

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