Fibrin Glue as a Sealant for High-Risk Anastomosis in Surgery for Morbid Obesity

Liu, Carson D.; Glantz, Gerald; Livingston, Edward H.

doi:10.1381/096089203321136575

Cited by 89 publications

(56 citation statements)

References 6 publications

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“…In a randomized study on esophageal anastomoses in infants born with esophageal atresia, a significantly reduced incidence of anastomotic leakage and stricture was found in the group sealed with FG [85]. Two human studies on FG sealing of anastomoses in patients with Roux-en-Y gastric bypass found a nonsignificantly decreased incidence of anastomotic leakage in the sealing group [86,87]. Another human study on anastomotic leakage after laparoscopic resection of rectal cancer found a leakage rate of 5.8% in the FG-sealed group compared with 10.9% in the nonsealed group.…”

Section: Discussionmentioning

confidence: 99%

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Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

et al. 2014

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Background/Aim: Anastomotic leakage remains a frequent and serious complication in gastrointestinal surgery. In order to reduce its incidence, several clinical and experimental studies on anastomotic sealing have been performed. In a number of these studies, the sealing material has been fibrin glue (FG), and the results in individual studies have been varying. The positive effect of anastomotic sealing with FG might be due to the mechanical/physical properties, the increased healing of the anastomoses or both. The aim of this systematic review was to evaluate the existing evidence on the healing effects of FG on gastrointestinal anastomoses. Methods: PubMed, EMBASE and the Cochrane databases were searched for studies evaluating the healing process of gastrointestinal anastomoses after any kind of FG application. The search period was from 1953 to December 2013. Results: Twenty-eight studies were included in the qualitative synthesis. These studies were all experimental studies, since no human studies used histological or biochemical evaluation of healing. In 7 of the 28 studies, a positive effect of FG on healing was found, while 8 studies reported a negative effect and 11 studies found no effect. Furthermore, 2 studies reported unclear results. The difference in the study outcome was independent of the study design and the type of FG used. Conclusion: In the available studies, FG did not consistently have a positive influence on the healing of gastrointestinal anastomoses. It is consequently plausible that the positive effect of FG sealing of gastrointestinal anastomoses, if there is any, may be due to a mechanical sealing effect rather than due to improved healing per se.

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Section: Discussionmentioning

confidence: 99%

“…Unfortunately, many of these attempts have failed to show convincing results [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48]. Numerous studies have reported on the sealing of gastrointestinal anastomoses with fibrin glue (FG), also called fibrin sealant.…”

Section: Introductionmentioning

confidence: 99%

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

et al. 2014

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“…Oversewing the staple line [4], the use of fibrin sealants [3,9,17,24], and the application of buttressing material [18,25] have all been evaluated in the literature as possible options to minimize postoperative ASL.…”

Section: Discussionmentioning

confidence: 99%

Decreasing anastomotic and staple line leaks after laparoscopic Roux-en-Y gastric bypass

2009

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“…Certainly the use of these products in anastomosing other structures such as vas deferens, nerves, and hollow viscus is well reported in the literature. [52][53][54][55][56][57] However, concerns regarding the inherent thrombogenicity of these products and the potential for triggering intraluminial thrombosis exist. 58 Although promising animal studies have been published, [59][60][61][62][63][64] few clinical series exist.…”

Section: Adhesivesmentioning

confidence: 99%

Technology‐assisted and sutureless microvascular anastomoses: Evidence for current techniques

et al. 2011

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Of the available forms of assisted microvascular anastomoses, there is level 2b evidence suggesting a positive outcome with the use of the Unilink™/3M™ coupler and the Autosuture™ VCS® clip applicator. Other techniques such as cyanoacrylates, fibrin glues, the Medtronic™ U-Clip®, and laser bonding have low levels of evidence supporting their use. Further research is required to establish any role for these techniques.

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Fibrin Glue as a Sealant for High-Risk Anastomosis in Surgery for Morbid Obesity

Cited by 89 publications

References 6 publications

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

Decreasing anastomotic and staple line leaks after laparoscopic Roux-en-Y gastric bypass

Technology‐assisted and sutureless microvascular anastomoses: Evidence for current techniques

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