Fibrin glue application through the flexible fiberoptic bronchoscope: Closure of bronchopleural fistulas

Glover, W. Lloyd; Chavis, Timothy V.; Daniel, Thomas M.; Krön, Irving L.; Spotnitz, William D.

doi:10.1016/s0022-5223(19)36427-x

Cited by 103 publications

(22 citation statements)

References 7 publications

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“…Since the first reported successful endobronchial management of BPF using tissue glue and a lead shot [19], many reports using different materials have been attempted. These include ethanol [20], silver nitrate [21], polyethylene glycol [22], cyanoacrylate compounds [23][24][25], coils [26,27], fibrin or tissue glue [28][29][30], doxycycline [31,32], albumin-glutaraldehyde tissue adhesive [33,34], cellulose [35], balloon catheter occlusion [36], calf bone [6], stents [6], gel foam [37], Watanabe spigots [38], endobronchial valves (EBV) [39][40][41], vascular devices and plugs [10,[42][43][44][45] pleurodesis (ABP) [46][47][48]. Each has their own inherent limitations and their reported success rates vary widely.…”

Section: Treatmentmentioning

confidence: 99%

Persistent air leak - review

Sakata

Reisenauer

Kern

et al. 2018

Respiratory Medicine

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A persistent air leak (PAL) can be caused by either an alveolar-pleural fistula (APF) or bronchopleural fistula (BPF). Complications from PAL lead to an increase in morbidity and mortality, prolonged hospital stay, and higher resource utilization. Pulmonary physicians and thoracic surgeons are often tasked with the difficult and often times frustrating diagnosis and management of PALs. While most patients will improve with chest tube thoracostomy, many will fail requiring alternative bronchoscopic or surgical strategies. Herein, we review the bronchoscopic and surgical diagnostic and treatment options for PAL as it pertains to the field of interventional pulmonology and thoracic surgery.

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Section: Treatmentmentioning

confidence: 99%

Persistent air leak - review

Sakata

Reisenauer

Kern

et al. 2018

Respiratory Medicine

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“…Several beneficial effects have been described in clinics with the application of fibrin sealant preparations: reduction in air or fluid leakage from pulmonary parenchymal staple lines, reenforcement of esophageal anastomoses, closing of bronchopleural fistulas (especially those less than 4 mm in diameter), using a fiberoptic flexible bronchoscope, and treatment of pneumothorax using video-assisted surgical techniques. It has also been used for closure of trachoesophageal [46] and bronchopleural [47,48] fistulae by fiberoptic bronchoscopic application. The efficacy of fibrin sealant, in comparison with sutures alone, for avoiding bronchial and alveolar leakages after pulmonary resections was demonstrated in a prospective and randomized clinical trial [49].…”

Section: Thoracic Surgerymentioning

confidence: 99%

Fibrin Sealant: Scientific Rationale, Production Methods, Properties, and Current Clinical Use

Radosevich¹,

Goubran²,

Burnouf³

1997

Vox Sanguinis

191

127

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Fibrin sealant is a complex plasma-derived product which is increasingly used as a biodegradable tissue adhesive or sealant to stop or control bleeding or provide air and fluid tightness in many surgical situations. This review describes the historical development of current fibrin sealant preparations and the scientific rationale behind the alleged physiological benefits of its major plasma-derived components. A comparison in the extraction methods and viral reduction treatments applied to current commercial products and autologous preparations, and their respective advantages and limits, are discussed. Application devices used for surgical applications are described. A survey of the major clinical applications in various surgical areas is presented. Current issues in terms of viral safety, definition of optimal fibrin sealant composition, and regulatory concerns, especially to demonstrate clinical efficacy, are also included.

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“…Fibrin glue has been used, both alone and with other adjuncts such as spongy calf bone fragments, to seal both visible central BPFs and bronchi leading to peripheral leaks. 43,44 Hollaus et al 44 treated 45 male patients endoscopically with BPF, 42 of whom had pulmonary resections for lung cancer, between 1983 and 1996. Rigid bronchoscopy and general anesthesia were employed in all cases.…”

Section: Tissue Glues and Sealantsmentioning

confidence: 99%

Management of Pneumothorax and Prolonged Air Leak

Slade

2014

Semin Respir Crit Care Med

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Pneumothorax refers to the presence of air within the pleural cavity, which may arise from a spontaneous defect in the visceral pleural surface, or through iatrogenic or other thoracic trauma. The most common cause in the developed world is iatrogenic pneumothorax. Most frequently, it can be managed conservatively or through simple pleural aspiration or drainage. A persistent air leak, >2 days' duration, develops in one-third of patients. When patients are managed with chest drainage alone, the median time for resolution of air leak is longer in patients with a pneumothorax secondary to an underlying lung disease (11 vs. 7 days). Interventional pulmonology is not usually required for the resolution of simple pneumothorax, but offers important minimally invasive techniques for treating persistent air leak and bronchopleural fistula. Following assessment of the site of the air leak within the bronchial tree, techniques are described for the sealing of leak using tissue or fibrin glues, endobronchial devices of various kinds, and combination approaches. Bronchoscopic sealing of air leaks can often avoid the requirement for thoracic surgical intervention. They may prove life-saving in patients who are difficult to wean from mechanical ventilation or extracorporeal membrane oxygenation because of catastrophic air leaks.

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Fibrin glue application through the flexible fiberoptic bronchoscope: Closure of bronchopleural fistulas

Cited by 103 publications

References 7 publications

Persistent air leak - review

Persistent air leak - review

Fibrin Sealant: Scientific Rationale, Production Methods, Properties, and Current Clinical Use

Management of Pneumothorax and Prolonged Air Leak

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