Fibrin Glue and Its Alternatives in Peripheral Nerve Repair

Chow, Nathan; Miears, Hunter; Cox, Cameron

doi:10.1097/sap.0000000000002408

Cited by 14 publications

(8 citation statements)

References 63 publications

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“…Since the 20% Gel-ADH/OSA 1:1 has more sites to react with amino groups on the surface of skin tissue, the lap shear strength (45 ± 14 kPa) and peel stress (28 ± 6 kPa) were higher than those of other groups, including the commercial adhesive Porcine Fibrin Sealant Kit. Previous studies also showed that the Fibrin Sealant has limited adhesion strength ( Chow et al, 2021 ). To further confirm the biomedical application potential of the hydrogel adhesive, wound sealing and healing investigation will be performed in the future animal studies.…”

Section: Resultsmentioning

confidence: 94%

Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

et al. 2021

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To assist or replace the traditional suture techniques for wound closure, soft-tissue adhesives with excellent adhesion strength and favorable biocompatibility are of great significance in biomedical applications. In this study, an injectable hydrogel tissue adhesive containing adipic acid dihydrazide–modified gelatin (Gel-ADH) and oxidized sodium alginate (OSA) was developed. It was found that this tissue adhesive possessed a uniform structure, appropriate swelling ratio, good injectability, and excellent hemocompatibility and cytocompatibility. The adhesion capacity of the developed adhesive with optimized component and concentration was stronger than that of the commercial adhesive Porcine Fibrin Sealant Kit. All these results suggested that the developed hydrogel was a promising candidate for a soft-tissue adhesive.

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Section: Resultsmentioning

confidence: 94%

Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

et al. 2021

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“…The cause of a gradually expanding PGS after repair of the thoracic aorta remains unknown; however, we believe that applying fibrin glue to the graft surface and wrapping a new graft around it prevents the recurrence of fluid accumulation around the prosthetic graft. It has been reported that fibrin glue reduces the inflammatory process [ 7 ]. Higashi et al [ 8 ] demonstrated that the new method, rubbing solution of fibrin glue with the finger, increased the resistance to pressure.…”

Section: Discussionmentioning

confidence: 99%

Expanding perigraft seroma after ascending aorta replacement

Kanemitsu

Sakamoto

Teranishi

et al. 2022

J Cardiothorac Surg

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Background Perigraft seroma is a persistent and sterile fluid confined within a fibrous pseudomembrane surrounding a graft that develops after graft replacement. Development of perigraft seroma is an uncommon complication that occurs after the surgical repair of the thoracic aorta using woven polyester grafts. mechanism underlying perigraft seroma formation remains unclear. Case presentation Herein, we describe the case of 77-year-old man who underwent repeat sternotomy for the treatment of large perigraft seroma 1 year after ascending aorta replacement for acute type A dissection. After removing a cloudy yellow fluid, we covered the prosthetic graft with fibrin glue and wrapped it with a new graft. Bacterial culture and laboratory examination of the fluid confirmed the final diagnosis of perigraft seroma, and there was no evidence of recurrence. The area in which fluid accumulated around the graft shrunk 1 year after surgery. Conclusions The cause of a expanding perigraft after repair of the thoracic aorta remains unknown. Physicians should be aware that chronic expanding mediastinal seroma with Dacron grafts is one of the rare postoperative complications of thoracic aortic surgery. Applying fibrin glue to the graft surface might effectively prevent the recurrence of perigraft seroma.

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“…It can imitate the process of fibrinogen forming fibrin monomer under the action of thrombin and calcium ion in the coagulation process, and finally form stable blood clot to achieve the hemostatic effect [30]. It is often used for hemostasis of the organs in abdominal surgery, but this material leads to serious postoperative adhesion [31,32]. Hong et al [33] prepared a matrix gel that mimics the extracellular matrix.…”

Section: Fluid Seal Typementioning

confidence: 99%

A Narrative Review of Different Hemostatic Materials in Emergency Treatment of Trauma

Xiao¹,

2022

Emergency Medicine International

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Hemostatic materials are very important for the treatment of a large number of bleeding trauma patients in battlefield and disaster environments. Different types of hemostatic materials need to be used for emergency hemostasis according to different injury parts and severity. At present, the first-aid hemostatic materials have been well applied to the bleeding of body surface wounds, limbs, and junctions, but there are still no ideal hemostatic materials in the early treatment of first aid for the deep and incompressible bleeding of thoracoabdominal cavity and visceral organs. This paper reviews the classification and mechanism of hemostatic materials, as well as the application and research progress in trauma emergency, so as to provide reference for the application of hemostatic materials in early first-aid emergency.

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Fibrin Glue and Its Alternatives in Peripheral Nerve Repair

Cited by 14 publications

References 63 publications

Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

Expanding perigraft seroma after ascending aorta replacement

A Narrative Review of Different Hemostatic Materials in Emergency Treatment of Trauma

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