Fibrin Glue Achieves Hemostasis in Patients With Coagulation Disorders

Kram, Harry B.; Nathan, Ragu C.; Stafford, Frederick J.; Fleming, Arthur W.; Shoemaker, William C.

doi:10.1001/archsurg.1989.01410030135023

Cited by 51 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two-component fibrin glues are mainly composed of bovine or human thrombin and concentrated fibrinogen, duplicating the final stage of the coagulation cascade. This makes it possible to apply them to bleeding lesions and even to patients with coagulation disorders (Guilmet et al, 1979;Kram et al, 1989). Fibrin glues can be also used for skin closure in cosmetic surgery (Matras, 1985;Scardino et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

Park

Kim

Lee

et al. 2002

Journal of Veterinary Medicine Series A

View full text Add to dashboard Cite

To control intra-operative haemorrhage, fibrin glues are preferred by many surgeons because of their biological advantages and convenience of application. Manufacturers have developed a few kinds of fibrin glues with a little difference in their composition. This study was to compare the effectiveness of two commercially available fibrin glues; Greenplast (Green Cross P. D. Company, Yongin, Korea) and Tisseel (Baxter-Immuno AG, Vienna, Austria). They were applied experimentally to several kinds of surgery in dogs - renal vessel anastomosis, partial splenectomy, intestinal anastomosis and incision skin wound - and evaluated for their haemostatic and adhesive effects. When the two glues were applied in renal vessel anastomosis, the amount of haemorrhage in artery and vein decreased significantly. They also decreased the haemorrhage in partial splenectomy. At 10 min after application of the glues to an incision skin wound, the tensile strengths developed were significantly higher than that of control. The present study indicates that two-component fibrin glues have a haemostatic effect as a mechanical barrier in renal vessel anastomosis and an adhesive effect in the early stage of incision skin wound closure, and the two glues have similar effects with no complications.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

Park

Kim

Lee

et al. 2002

Journal of Veterinary Medicine Series A

View full text Add to dashboard Cite

show abstract

“…In a patient with stable and persistent thrombocytopenia, we believe Tisseel would be the safest option to offer the greatest uninterrupted healing time in a high-risk patient before dissolution of the developed clot. Fibrin glue has also been used as a hemostatic agent in patients with coagulation disorders and in many cases of surgical hemostatic control for deep and superficial renal parenchymal bleeding 3 . These fibrin products do not depend on adequacy of platelet or clotting factors suggesting that Tisseel may be used for thrombocytopenia due to the fibrin component.…”

Section: Discussionmentioning

confidence: 99%

A Novel Use of Tisseel in the Setting of Uncontrolled Bleeding in a Thrombocytopenic Patient With Idiopathic Thrombocytopenia

Fisher

Gonzalez

Spiess

2016

Urology Case Reports

View full text Add to dashboard Cite

We present a case of an 87-year-old female who was evaluated for an 8.5 cm left sided renal mass concerning for malignancy. The patient was transiently thrombocytopenic over the previous 4 months with platelet counts ranging from 50,000 to 125,000 plt/mcL and experienced diffuse hemorrhage during radical nephrectomy with failure to achieve mechanical hemostasis or fulguration. Following Surgicel (Ethicon; Somerville, New Jersey) application, we applied Tisseel (Baxter; Deerfield, IL) to the nephrectomy bed with complete hemostasis of bleeding foci. Tisseel saved this thrombocytopenic patient with uncontrolled bleeding and should have this clinical utility recognized.

show abstract

“…Wound healing is enhanced with fibrin glue and increased tensile strength has been noted [7]. It has achieved clotting in patients 271 with coagulopathies due to massive transfusions, chronic diseases, and inflammatory conditions [8,13]. Family members can act as directed donors to provide a safe source of fibrinogen in either elective or emergency situations.…”

Section: Discussionmentioning

confidence: 99%

Minimal suture blepharoplasty: Closure of incisions with autologous fibrin glue

Mandel¹

1992

Aesth. Plast. Surg.

View full text Add to dashboard Cite

Blepharoplasty incisions can be cloned safely with autologous fibrin glue. The fibrinogen, prepared either from a whole-blood or plasmapheresis source, is mixed with commercially available thrombin to form a seal that is both hemostatic and adhesive. The complication rate is low and primarily due to technical factors in the initial cases. When compared with standard suture techniques, the incidence of minor problems such as milia formation was much lower. In select cases, the technique of using fibrin glue and a minimal number of sutures may be useful as an alternative method of wound closure in blepharoplasty patients.

show abstract

Fibrin Glue Achieves Hemostasis in Patients With Coagulation Disorders

Cited by 51 publications

References 9 publications

Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

A Novel Use of Tisseel in the Setting of Uncontrolled Bleeding in a Thrombocytopenic Patient With Idiopathic Thrombocytopenia

Minimal suture blepharoplasty: Closure of incisions with autologous fibrin glue

Contact Info

Product

Resources

About