Fibrin Formation in Shear Flow: A and B Peptide Release

Abstract

Fibrinogen reacted with thrombin at pH 6.3 in shear flow fields varying from 0 to 150 sec-1 gives insoluble fibrin at differing ratio, with a minimum rate near 50 sec-1. The relative rate of release of A and B peptides is also altered by the shear flow field. The release or B peptide is faster in stagnant solutions than in the higher shear flow.