Abstract:Cancer is associated with a high risk of venous thromboembolism (VTE) and its recurrence. There is evidence that the prothrombotic fibrin clot phenotype, involving the formation of denser and stiffer clots relatively resistant to lysis, occurs in cancer patients, which is in part related to enhanced inflammation, oxidative stress, and coagulation activation, along with the release of neutrophil extracellular traps, indicating that fibrin-related mechanisms might contribute to cancer-associated thrombosis (CAT)… Show more
“…From thrombin to fibrin, Ząbczyk and Undas reviews the importance of fibrin clot properties in CAT. 11 Altered clot properties have been described in various cancer types including both hematological and solid tumors, and resistance to lysis has been associated with future VTE risk in multiple myeloma patients. The authors summarize our current knowledge on the mechanisms behind altered clot properties in cancer and the implications for CAT prophylaxis and treatment.…”
“…From thrombin to fibrin, Ząbczyk and Undas reviews the importance of fibrin clot properties in CAT. 11 Altered clot properties have been described in various cancer types including both hematological and solid tumors, and resistance to lysis has been associated with future VTE risk in multiple myeloma patients. The authors summarize our current knowledge on the mechanisms behind altered clot properties in cancer and the implications for CAT prophylaxis and treatment.…”
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