Fibrin clot properties and thrombus composition in cirrhosis

Driever, Ellen G.; Lisman, Ton

doi:10.1016/j.rpth.2023.100055

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Rationale For Anticoagulation In Patients With Cirrhosis1

Introduction1

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2023

2024

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Article5

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Cited by 5 publications

(2 citation statements)

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“…Of note, PVT can also be a direct consequence of portal hypertension in addition to haemostatic alterations. 33 , 46 , 47 …”

Section: Rationale For Anticoagulation In Patients With Cirrhosismentioning

confidence: 99%

Direct oral anticoagulants in cirrhosis: Rationale and current evidence

Pereira Portela,

Gautier,

Zermatten

et al. 2024

JHEP Reports

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“…Of note, PVT can also be a direct consequence of portal hypertension in addition to haemostatic alterations. 33 , 46 , 47 …”

Section: Rationale For Anticoagulation In Patients With Cirrhosismentioning

confidence: 99%

Direct oral anticoagulants in cirrhosis: Rationale and current evidence

Pereira Portela,

Gautier,

Zermatten

et al. 2024

JHEP Reports

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“…Dangerous thrombotic events, such as stroke, heart attack, or VTE, have been associated with altered structural properties of the in vitro plasma clots made from the blood of these patients [14][15][16][17][18][19]. Diseases such as cancer [20,21], diabetes [14,22], and COVID-19 [23,24] have also been linked to the altered structural properties of in vitro plasma clots, which could potentially impede clot degradation and increase the risk of thrombotic events [25].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen

Risman,

Belcher,

Ramanujam

et al. 2024

Biomolecules

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Altered properties of fibrin clots have been associated with bleeding and thrombotic disorders, including hemophilia or trauma and heart attack or stroke. Clotting factors, such as thrombin and tissue factor, or blood plasma proteins, such as fibrinogen, play critical roles in fibrin network polymerization. The concentrations and combinations of these proteins affect the structure and stability of clots, which can lead to downstream complications. The present work includes clots made from plasma and purified fibrinogen and shows how varying fibrinogen and activation factor concentrations affect the fibrin properties under both conditions. We used a combination of scanning electron microscopy, confocal microscopy, and turbidimetry to analyze clot/fiber structure and polymerization. We quantified the structural and polymerization features and found similar trends with increasing/decreasing fibrinogen and thrombin concentrations for both purified fibrinogen and plasma clots. Using our compiled results, we were able to generate multiple linear regressions that predict structural and polymerization features using various fibrinogen and clotting agent concentrations. This study provides an analysis of structural and polymerization features of clots made with purified fibrinogen or plasma at various fibrinogen and clotting agent concentrations. Our results could be utilized to aid in interpreting results, designing future experiments, or developing relevant mathematical models.

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D-dimers in advanced liver cirrhosis: Useful biomarker or not?

Balaceanu,

Dina

2024

The American Journal of the Medical Sciences

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Fibrin clot properties and thrombus composition in cirrhosis

Cited by 5 publications

References 83 publications

Direct oral anticoagulants in cirrhosis: Rationale and current evidence

Direct oral anticoagulants in cirrhosis: Rationale and current evidence

Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen

D-dimers in advanced liver cirrhosis: Useful biomarker or not?

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