Fibrin adhesive in the treatment of perineal fistulas

Hjortrup, A; Moesgaard, F; Kjærgård, Johan

doi:10.1007/bf02051064

Cited by 123 publications

(82 citation statements)

References 9 publications

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“…Many advantages have been described using fibrin glue in the treatment of anal fistulas. It is simple, repeatable, with minor surgical trauma so sphincter function is preserved and further surgical treatment is not compromised [12,13,14,15,16,17,18,19,20,21,22,23]. Recent publications show promising results using this technique.…”

Section: Introductionmentioning

confidence: 96%

Treatment of Fistulas in ano with Fibrin Glue

et al. 2005

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Background: Recent publications show promising results using fibrin glue in the treatment of anal fistulas. The technique is simple, repeatable, with minor surgical trauma so that sphincter function is preserved and further treatment options are not compromised. The aim of this pilot study was to analyse if we could reproduce the results reported in the literature, using this simple technique. Methods: Patients with a primary or recurrent anal fistula were included in this trial. Patients with a complex fistula were excluded. Under general or spinal anaesthesia, the fistulas were curetted and injected with fibrin glue. Follow-up visits were scheduled for 1 week, 6 weeks and 6 months. Results: Twenty-seven patients were included. The overall success rate was 33% after a mean follow-up of 27 weeks. Patients with a recurrent fistula had a poorer outcome (success rate 14%). None of the patients suffered from postoperative continence problems, and no other complications were recorded. Conclusion: This study confirms the safety of fibrin glue in the treatment of anal fistulas. However, a high success rate could not be reproduced.

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Section: Introductionmentioning

confidence: 96%

Treatment of Fistulas in ano with Fibrin Glue

et al. 2005

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“…Abel et al 12 used cryoprecipitatebased autologous fibrin tissue adhesive (AFTA-C) to treat rectovaginal and complex fistulae in 10 patients and reported an overall success rate of 60%. Hjortrup et al 13 from Denmark reported the use of a commercial fibrin sealant (Beriplast; Behringwerke, Marburg, Germany) in the treatment of 15 patients with persistent perineal sinus after proctectomy and 8 patients with abscess fistulae. They reported an overall closure rate of 74% (17/ 23); however, 5 patients (22%) required 2 or 3 attempts at sealant closure.…”

Section: Commentmentioning

confidence: 99%

Repair of Chronic Anorectal Fistulae Using Commercial Fibrin Sealant

Park¹,

Cintron²,

Orsay

et al. 2000

Arch Surg

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“…Fibrin glue was the first biological material used for fistula repair (14), and this has been followed by other noninvasive techniques such as plugging (15), stem cells (16) and Nitinol clips (17). However, only mixed results have been achieved.…”

Section: Discussionmentioning

confidence: 99%

Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin

Lara¹,

Berges²,

González³

et al. 2016

Ann Colorectal Res

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Surgical treatment of high perianal fistulas, which affect a significant proportion of the sphincter apparatus, is difficult and associated with considerable risk of impaired anal continence. The diversity of approaches proposed for the treatment of complex perianal fistulas reflects the fact that no method has yet been shown to be fully satisfactory. We believe the successful treatment of this condition is directly proportional to the amount of fibrous tissue that can be removed. We used a kit of small curettes, of different thicknesses and sizes, incorporating spicules that enable the physician to remove fibrous tissue from the fistula tract. The small size and varying thicknesses of the curettes enable them to mold to the curves of the fistula tract and to remove tissue by de-roofing from the shallowest to the deepest layers, thus excising the entire fibrous tract. The tract is then sealed using autologous fibrin, applied through a catheter, with the help of a monitor indicating the amount of product remaining at all times. Finally, the internal orifice is closed by simple suturing.

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Fibrin adhesive in the treatment of perineal fistulas

Cited by 123 publications

References 9 publications

Treatment of Fistulas in ano with Fibrin Glue

Treatment of Fistulas in ano with Fibrin Glue

Repair of Chronic Anorectal Fistulae Using Commercial Fibrin Sealant

Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin

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