Fibril-shaped aggregates of doxorubicin with poly-<scp>l</scp>-lysine and its derivative

Zhu, Lijun; Yang, Saina; Qu, Xiaozhong; Zhu, Fuliang; Liang, Yongri; Liang, Fuxin; Wang, Qian; Li, Jiaoli; Li, Zhibo; Yang, Zhenzhong

doi:10.1039/c4py00686k

Cited by 24 publications

(43 citation statements)

References 48 publications

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“…Of note, the formation of cylindrical aggregates is specific to SQ-Dox and contrasts with the shape of other squalene-based nanoparticles. − We assume that it originates from Dox stacking. Indeed, Dox is known to self-assemble in aqueous solution to form dimers, in parallel or antiparallel orientation, oligomers, or fibers, depending on the concentration, the pH of the solution, and the presence of added salts. − The absorbance and fluorescence spectra of SQ-Dox in water confirmed the stacking of Dox moieties in nanoparticles for concentration above 5 μM (Figure S5).…”

Section: Results and Discussionmentioning

confidence: 88%

Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin

et al. 2019

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The development of elongated nanoparticles for drug delivery is of growing interest in recent years, due to longer blood circulation and improved efficacy compared to spherical counterparts. Squalenoyl-doxorubicin (SQ-Dox) conjugate was previously shown to form elongated nanoparticles with improved therapeutic efficacy and decreased toxicity compared to free doxorubicin. By using experimental and computational techniques, we demonstrate here that the specific physical properties of SQ-Dox, which include stacking and electrostatic interactions of doxorubicin as well as hydrophobic interactions of squalene, are involved in the formation of nanoassemblies with diverse elongated structures. We show that SQ-Dox bioconjugate concentration, ionic strength, and anion nature can be used to modulate the shape and stiffness of SQ-Dox nanoparticles. As those parameters are involved in nanoparticle behavior in biological media, these findings could bring interesting opportunities for drug delivery and serve as an example for the design of original nanodrugs with stacking properties tuned for particular clinical purposes.

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Section: Results and Discussionmentioning

confidence: 88%

Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin

et al. 2019

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“…Alternatively, there are evidences that Dox itself and other hydrophobic drugs would self-assemble into bril-shaped aggregates under physiological condition. [29][30][31] Therefore, it is likely that in our system, Dox moieties aggregate and form the hydrophobic core, while the PGA chains take mixed a-helix and random coil secondary structure and form the hydrophilic sheath of the brils.…”

Section: Resultsmentioning

confidence: 98%

Fibril aggregates of the poly(glutamic acid)–drug conjugate

Lai

Huang

2015

RSC Adv.

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“…As a consequence, the retrogradation may occur in a greater extent leading to significant variations of the contact angle measurements for CSpd35 and CSg35 materials. However, plasticizer migration effects have to be considered during the storage time of the films, especially in those containing glycerol. For this reason, the angle measurement could be affected by the accumulation of plasticizer molecules in the surface.…”

Section: Resultsmentioning

confidence: 99%

D‐isosorbide and 1,3‐propanediol as plasticizers for starch‐based films: Characterization and aging study

González

Martin

González

et al. 2017

J of Applied Polymer Sci

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In the present work, D‐isosorbide and 1,3‐propanediol are proposed as alternative plasticizers obtained from renewable resources. Plasticized starch films were prepared by solvent casting method. The influence of using different “green” plasticizers in the final properties of starch‐based films was analyzed. Besides, the characterization of the films was also performed after storage time in order to evaluate the effect of the plasticizer on aging. UV‐spectrophotometry results showed better optical properties for both glycerol and D‐isosorbide films with higher transparency. The thermal and mechanical properties resulted influenced by the nature of the plasticizer. It was demonstrated that water vapor permeability was governed by the starch‐water interactions, whereas the oxygen permeability depended on the plasticizer's nature. The storage time affected the surface, mechanical, and thermal properties of the plasticized starch films. Atomic force microscopy results concluded that the topography of the films changed due to aging. The use of D‐isosorbide as plasticizer reduced the evolution of the mentioned properties and enhanced the reliability of the material. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44793.

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Fibril-shaped aggregates of doxorubicin with poly-l-lysine and its derivative

Abstract: Doxorubicin forms fibril-like aggregates in phosphate buffer and complexes with poly-l-lysine and cholate-grafted poly-l-lysine.

Cited by 24 publications

References 48 publications

Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin

Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin

Fibril aggregates of the poly(glutamic acid)–drug conjugate

D‐isosorbide and 1,3‐propanediol as plasticizers for starch‐based films: Characterization and aging study

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