Fibreoptic methods of cross-polarisation optical coherence tomography for endoscopic studies

Gelikonov, Valentin M.; Gelikonov, Grigory V.

doi:10.1070/qe2008v038n07abeh013857

Cited by 11 publications

(5 citation statements)

References 37 publications

(54 reference statements)

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“…If no polarization changes occur in the tissue, then signal brightness in the CP part of the image is zero. Only depolarized reflected light can interfere with reference light orthogonal to the incident light [38].…”

Section: Methodsmentioning

confidence: 99%

Cross‐polarization optical coherence tomography for early bladder‐cancer detection: statistical study

Gladkova

Streltsova

Zagaynova

et al. 2010

Journal of Biophotonics

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The capabilities of cross-polarization optical coherence tomography (CP OCT) for early bladder-cancer detection are assessed in statistical study and compared with the traditional OCT. Unlike the traditional OCT that demonstrates images only in copolarization, CP OCT acquires images in cross-polarization and copolarization simultaneously. 116 patients with localized flat suspicious lesions in the bladder were enrolled, 360 CP OCT images were obtained and analyzed. CP OCT demonstrated sensitivity 93.7% (vs. 81.2%, <0.0001), specificity 84% (vs. 70.0%, <0.001) and accuracy 85.3% (vs. 71.5%, <0.001) in detecting flat malignant bladder lesions, which is significantly better than with the traditional OCT. Higher diagnostic efficacy of CP OCT in detecting early bladder cancer is associated with the ability to detect changes in epithelium and connective tissues.

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Section: Methodsmentioning

confidence: 99%

Cross‐polarization optical coherence tomography for early bladder‐cancer detection: statistical study

Gladkova

Streltsova

Zagaynova

et al. 2010

Journal of Biophotonics

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“…1(b)]. 27,28 The device is based on common-path autocorrelator scheme 29,30 and utilized cross-polarization reception channel. 31,32 It is approved for clinical use (product license No̱ FCP 2012/13479 of 30 May 2012) and has the following characteristics: the source of radiation is a superluminescent diode with a working wavelength of 1310 nm, a spectrum width of 100 nm, an axial resolution of 15 m, a lateral resolution of 25 m and a radiation power of 3 mW.…”

Section: Cp Oct Studymentioning

confidence: 99%

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

Kiseleva

Moiseev

Kuyarov

et al. 2020

J. Innov. Opt. Health Sci.

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The paper presents the results of a study of the female urethra in cases of urethral pain syndrome (UPS) and inflammatory diseases of the lower urinary tract using cross-polarization optical coherence tomography (CP OCT). Urethral wall structure was studied in 86 patients; 233 CP OCT images were collected. A comparative qualitative analysis of three groups of CP OCT images — “norm”, “Inflammation” and “UPS” — identified that despite the absence of a clear inflammatory factor in the patient’s examination, the urethral tissues in UPS were in an altered state. The changes in the urethral wall with UPS and in cases of inflammation were similar. Using a point scale, three experts independently performed visual scoring of the CP OCT images. Three parameters: epithelial contrast, cavities and the minimum signal depth in the co-channel were evaluated. It was found that, individually, the parameters correlate only weakly with the diagnosis. Area under the receiver operating characteristic (ROC) curve was from 0.51 to 0.78. The joint use of a number of visual signs has a greater diagnostic value than the use of the criteria individually. Area under the ROC curve using the developed cumulative criterion reached up to 0.87–0.89. This study could form the basis of a scoring system for assessing the state of the urethral tract using CP OCT images in real time. The CP OCT method provides information on the state of urethral tissues that cannot be obtained with traditional cystoscopy.

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“…Time-domain device “Polarization-sensitive optical coherence tomograph OCT-1300U” (BioMedTech LLC, Nizhny Novgorod, Russia) ( Figure 1 a), that provides two image acquisition in co- and cross-polarizations was used in the study [ 29 , 35 ]. The device is approved for clinical use (product license №FCP 2012/13479 of 30 May 2012) and is equipped with replaceable endoscopic probe ( Figure 1 b,c).…”

Section: Methodsmentioning

confidence: 99%

New Approaches in the Study of the Pathogenesis of Urethral Pain Syndrome

et al. 2020

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Introduction: Urethral pain syndrome (UPS) is still a pathology in which the diagnosis is formulated as a “diagnosis of exclusion”. The exact pathogenetic mechanisms are not yet fully understood and clear recommendations for the prevention and treatment of UPS are absent. Methods and Participants: A clinical and laboratory evaluation of 55 patients with established UPS included history taking, basic laboratory tests (e.g., complete blood count and clinical urine test), physical examination, uroflowmetry, and cystourethroscopy. Additionally, transvaginal ultrasound (TVUS) with compression elastography and cross-polarization optical tomography (CP OCT) were performed in 24 and 33 patients with UPS, respectively. The control group consisted of 14 patients with no complaints from the urinary system. Results: TVUS showed an expansion in the diameter of the internal lumen of the urethra, especially in the proximal region compared with the norm. Compression elastography revealed areas with increased stiffness (presence of fibrosis) in urethral and surrounding tissues. The performed CP OCT study showed that in UPS, the structure of the tissues in most cases was changed: trophic alterations in the epithelium (hypertrophy or atrophy) and fibrosis of underlying connective tissue were observed. The proximal fragment of the urethra with UPS underwent changes identical to those of the bladder neck. Conclusion: This paper showed that the introduction of new technology—CP OCT—in conjunction with TVUS will allow verification of structural changes in tissues of the lower urinary tract at the level of their architectonics and will help doctors understand better the basics of the UPS pathogenesis.

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Fibreoptic methods of cross-polarisation optical coherence tomography for endoscopic studies

Cited by 11 publications

References 37 publications

Cross‐polarization optical coherence tomography for early bladder‐cancer detection: statistical study

Cross‐polarization optical coherence tomography for early bladder‐cancer detection: statistical study

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

New Approaches in the Study of the Pathogenesis of Urethral Pain Syndrome

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