Fibre laser welding for packaging of disposable polymeric microfluidic-biochips

Boglea, Andrei; Olowinsky, Alexander; Gillner, Arnold

doi:10.1016/j.apsusc.2007.08.013

Cited by 53 publications

(24 citation statements)

References 4 publications

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“…Polymer behavior during laser transmission welding for different laser beam wavelengths has been studied in (Ref [7][8][9], while Laurens and Wonga (Ref 10,11) have examined the influence of laser beam in the process structuring of polymers. The evolution of temperature field within the organic matter during laser-polymer interaction has been analyzed using different numerical models ( .…”

Section: Introductionmentioning

confidence: 98%

Remelting of Flame Spraying PEEK Coating Using Lasers

et al. 2009

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International audienceFlame spraying is frequently used for polyether ether ketone (PEEK) and PTFE coating deposition on metallic surfaces. However, this process has a certain number of limitations, particularly on the coating quality such as high porosity, low interfacial adherence, etc. For that reason a thermal post-processing step is often necessary. The objective of this study is to analyze the effects produced during a laser beam heat treatment on morphological structure (compactness) of PEEK coatings and their mechanical properties (adherence and tribology). The influence of the laser beam wavelength (by using a Nd:YAG, CO2 or diode lasers) on compactness of the flame sprayed PEEK coating deposited on metallic substrate (304L) was analyzed. Since the value of laser light absorption coefficient of the PEEK coating depends on the laser wavelength, an optimization of the operational parameters for each laser has been carried out in order to achieve melting but not burning of the PEEK coating. Nevertheless, whatever the laser wavelengths used, the results showed a good effect of the laser treatment: improvement of both polymer coating compactness and its adherence to the substrate

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Section: Introductionmentioning

confidence: 98%

Remelting of Flame Spraying PEEK Coating Using Lasers

et al. 2009

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“…Earlier studies have shown that the temperature should not exceed 45-70 C for more than 2 min to keep the biomolecules functional. 11 Earlier studies such as Refs. 8, 11, 16, and 17 have used laser transmission welding to seal microfluidic devices.…”

Section: Malekmentioning

confidence: 99%

“…Different laser transmission welding methods have been successfully demonstrated for microfluidic components in several studies. For example, Boglea et al 11 have welded microfluidic chips with a method combining the characteristics of polymer contour welding and quasisimultaneous welding. The authors have named the method transmission welding by an incremental scanning technique (TWIST).…”

Section: Malekmentioning

confidence: 99%

“…Furthermore, bonding should not include unstable reagents (such as outgassing glue or solvents), and it should not damage or contaminate biomolecules used in the bioanalytical microdevices. [6][7][8] Polymer devices have been sealed using gluing, 7 lamination, 6,9 ultrasonic welding, 6,10 resistive welding, 11 and laser transmission welding. 6,11,12 Laser transmission welding offers several advantages in microfluidic applications compared with conventional joining techniques.…”

Section: Introductionmentioning

confidence: 99%

“…Even though the temperature rises during sealing, laser welding induces a reduced amount of stress into the joining materials compared to conventional methods, such as gluing, lamination, ultrasonic welding, and resistive welding, since the energy generation is highly localized in laser welding. [11][12][13] Laser transmission welding of thermoplastic polymeric materials is a widely used method in industry. Various fields, such as the automotive, mechanical, and electronics industries, have utilized the method for welding plastic macro parts.…”

Section: Introductionmentioning

confidence: 99%

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The effects of laser welding on heterogeneous immunoassay performance in a microfluidic cartridge

et al. 2011

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Sealing of a microfluidic cartridge is a challenge, because the cartridge commonly contains heat-sensitive biomolecules that must also be protected from contamination. In addition, the objective is usually to obtain a sealing method suitable for mass production. Laser welding is a rapid technique that can be accomplished with low unit costs. Even though the technique has been widely adopted in industry, the literature on its use in microfluidic applications is not large. This paper is the first to report the effects of laser welding on the performance of the heterogeneous immunoassay in a polystyrene microfluidic cartridge in which biomolecules are immobilized into the reaction surface of the cartridge before sealing. The paper compares the immunoassay performance of microfluidic cartridges that are sealed either with an adhesive tape or by use of laser transmission welding. The model analyte used is thyroid stimulating hormone (TSH). The results show that the concentration curves in the laser-welded cartridges are very close to the curves in the taped cartridges. This indicates, first, that laser welding does not cause any significant reduction in immunoassay performance, and second, that the polystyrene cover does not have significant effect on the signal levels. Interestingly, the coefficients of variance between parallel samples were lower in the laser-welded cartridges than in the taped cartridges.

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Enhanced Autohesive Bonding of Polyetheretherketone (PEEK) for Biomedical Applications Using a Methane/Oxygen Plasma Treatment

Awaja

Zhang

James

et al. 2010

Plasma Processes & Polymers

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High performance polymers such as PEEK are currently considered unsuitable for the encapsulation of biomedical implants, partly because of a lack of a strong and durable bonding technology. Strong autohesive bonds were achieved between semi‐crystalline PEEK surfaces using a treatment in RF plasma with a mixture of methane and oxygen (CH4/O2) gases. The surfaces were bonded under pressure above the glass transition temperature (Tg) and below the melting point (Tm). The treatment with CH4/O2 gases produced significantly higher bond strength than untreated samples and samples treated with CH4 only. The CH4/O2 plasma treatments generated a higher polar component of surface energy than observed for the untreated surfaces and also higher than that observed for surfaces plasma treated in CH4 alone. XPS analysis of surfaces treated with CH4/O2 plasma for more than 3 min showed that oxygenated nano‐films were deposited that contained CO groups and these showed the highest bonding strength. Free radical induced cross‐linking of the deposited nano‐film is proposed as a mechanism to explain the high bond strength achieved.

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Fibre laser welding for packaging of disposable polymeric microfluidic-biochips

Cited by 53 publications

References 4 publications

Remelting of Flame Spraying PEEK Coating Using Lasers

Remelting of Flame Spraying PEEK Coating Using Lasers

The effects of laser welding on heterogeneous immunoassay performance in a microfluidic cartridge

Enhanced Autohesive Bonding of Polyetheretherketone (PEEK) for Biomedical Applications Using a Methane/Oxygen Plasma Treatment

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