Fibre-laser IR luminescence diagnostics of malignant tumours using rare earth porphyrins

Spectroscopic properties of porphyrins and effect of lanthanide ions on their luminescence efficiency

“…2 shows absorption spectra of free porphyrins (H 2 TPP) and TbTPP(acac) in Nujol. The spectra differ in respect of the positions and the intensity ratios of the four Q band components (Q y (1,0) , Q y(0,0) , Q x (1,0) , Q x(0,0) [20]), as well as the molar absorption coefficients. The Soret band of the free porphyrin consists of two components (395.2 and 415.6 nm) and TbTPP(acac) exhibit only one (414.6 nm) but the shift between main components is not significant.…”

“…These features make them useful in cancer medicine and photodynamic therapy [1][2][3]. The porphyrins are molecules, whose physicochemical properties can be easily adjusted by modifications of the electronic distribution on the aromatic ring through peripheral substitutions that plays an important role in many biological systems and in photochemistry [4][5][6].…”

Near-Infrared Luminescent Labels and Probes Based on Lanthanide Ions and Their Potential for Applications in Bioanalytical Detection and Imaging

“…Until the early 1990s, there have been some reports of Yb 3+ -porphyrin complexes [14,15] and the ability of coloured metal indicators to act as photosensitisers for Nd 3+ and Yb 3+ [16,17]. Systematic studies of NIR luminescence in organic and aqueous media began in the middle of the 1990s with reports on Nd(III) [18][19][20], Yb(III) [9,18] and Er(III) [18,21].…”

“…Ytterbium-porphyrins could be localised in mice by fibre-laser fluorimetry [15], whereas particular Yb 3þ complexes can enter living cells and give detectable luminescence in cell suspensions [53,96]. One of such complexes has been used as a dual-function probe, combining near-infrared luminescence for detection and imaging (although NIR imaging was not demonstrated) and singlet oxygen generation for photodynamic action on malignant cells [53].…”

Nanoparticles Based on Lexan Polymer Matrix and the Ytterbium Complex of Porphyrin: Synthesis, Spectral-Luminescence Properties and Prospects of Using for Neoplasm Diagnostics

“…Обладая, наряду с другими порфириновыми соединени-ями достаточной туморотропностью, [2][3][4][5][6] они в то же время имеют ряд преимуществ, главное из которых снижение фотохимической активности. Дело в том, что введение ионов иттербия Yb 3+ в молекулу порфирина в значитель-ной степени снижает квантовый выход генерации синглет-ного кислорода.…”