Fiberoptic endoscopy evaluation of swallowing in patients with amyotrophic lateral sclerosis

D’Ottaviano, Fabiana Gonçalez; Filho, Tarcisio Aguiar Linhares; Andrade, Helen Maia Tavares de; Alves, Percilia Cardoso Lopes; Rocha, Maria Sheila Guimarães

doi:10.5935/1808-8694.20130061

Cited by 22 publications

(30 citation statements)

References 14 publications

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“…Observations from radiographic imaging and endoscopy include delayed swallow onset [15,39,41–44], the occurrence of penetration/aspiration [13,15,16,18,27,33,39,41–62] and post-swallow residue [15,16,33,39,41,42,44,47,49,52,53,57–63]. Additional reports from VFSS indicate reduced hyolaryngeal movement [15,33,43,45,53,64] and incomplete laryngeal closure [45,39].…”

Section: Discussionmentioning

confidence: 99%

Trends in Research Literature Describing Dysphagia in Motor Neuron Diseases (MND): A Scoping Review

et al. 2017

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Dysphagia in motor neuron diseases (MNDs) is highly complex, affecting all stages of swallowing and leading to impaired swallowing safety and efficiency. In order to explore the degree to which research is capturing the symptom of dysphagia in MND, we conducted a scoping review of the existing literature. The primary aims of this review were to identify common themes within the literature on dysphagia in MND, explore patterns and trends in research focus, and identify if any imbalances exist between the research themes related to dysphagia description and management. Methods A comprehensive search strategy yielded 1690 unique articles for review. Following relevance screening, a total of 157 articles were included in the synthesis. Relevant data and keywords were extracted from each article and grouped into themes. Frequency estimates were calculated for each theme to identify trends across research literature. Results Swallowing impairment in MNDs is described in a variety of ways across current research. The most commonly reported theme was Aspiration/Penetration, mentioned in 73.2% of all included articles; a significant imbalance was identified between reports of swallowing safety and efficiency (p=0.008). The most frequently reported theme related to dysphagia management was Enteral Nutrition, and very few studies have reported on the efficacy of Rehabilitation/Compensatory recommendations. Conclusions It is suggested that researchers and clinicians remain mindful of imbalances and gaps in research, and aim to characterize dysphagia in MNDs in a comprehensive manner. Further research investigating discrete, measureable changes in swallowing pathophysiology would be beneficial to delineate the key factors contributing to impaired swallowing safety and efficiency.

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Section: Discussionmentioning

confidence: 99%

Trends in Research Literature Describing Dysphagia in Motor Neuron Diseases (MND): A Scoping Review

et al. 2017

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“…VFSS with humans includes several consistencies of foods and liquid, and dysphagia is most apparent when swallowing thin liquids and dry, solid foods 44,45 . The murine VFSS protocol is therefore being expanded to include additional consistencies that may facilitate detection and quantification of dysphagia in disease models.…”

Section: Discussionmentioning

confidence: 99%

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Lever

Braun

Brooks

et al. 2015

JoVE

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This study adapted human videofluoroscopic swallowing study (VFSS) methods for use with murine disease models for the purpose of facilitating translational dysphagia research. Successful outcomes are dependent upon three critical components: test chambers that permit self-feeding while standing unrestrained in a confined space, recipes that mask the aversive taste/odor of commercially-available oral contrast agents, and a step-by-step test protocol that permits quantification of swallow physiology. Elimination of one or more of these components will have a detrimental impact on the study results. Moreover, the energy level capability of the fluoroscopy system will determine which swallow parameters can be investigated. Most research centers have high energy fluoroscopes designed for use with people and larger animals, which results in exceptionally poor image quality when testing mice and other small rodents. Despite this limitation, we have identified seven VFSS parameters that are consistently quantifiable in mice when using a high energy fluoroscope in combination with the new murine VFSS protocol. We recently obtained a low energy fluoroscopy system with exceptionally high imaging resolution and magnification capabilities that was designed for use with mice and other small rodents. Preliminary work using this new system, in combination with the new murine VFSS protocol, has identified 13 swallow parameters that are consistently quantifiable in mice, which is nearly double the number obtained using conventional (i.e., high energy) fluoroscopes. Identification of additional swallow parameters is expected as we optimize the capabilities of this new system. Results thus far demonstrate the utility of using a low energy fluoroscopy system to detect and quantify subtle changes in swallow physiology that may otherwise be overlooked when using high energy fluoroscopes to investigate murine disease models.

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“…If no aspiration was found, the patient was instructed to swallow larger volumes. In case of penetration (PAS, [2][3][4][5], the next consistency was tested until aspiration was detected. If aspiration was found for one consistency, the examination was terminated to prevent aspiration-associated pneumonia.…”

Section: Feesmentioning

confidence: 99%

“…Altman et al (1) estimated the costs of dysphagia treatment in hospitalized patients to amount up to $500 million per year in the United States. Clinical screening for dysphagia is routinely performed in stroke, but should also be considered in neurodegenerative disorders, traumatic brain injury, and neuromuscular disease (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). It is of importance that the clinical examination seems to have only a poor sensitivity for the detection of aspiration (14)(15)(16).…”

mentioning

confidence: 99%

Dysphagia—A Common, Transient Symptom in Critical Illness Polyneuropathy

Ponfick

Linden

Nowak

2015

Critical Care Medicine

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Dysphagia is frequent among patients with critical illness polyneuropathy treated in the ICU. Old age, chronic obstructive pulmonary disease, the mode of mechanical ventilation, the prevalence of tracheal tubes, and behavioral "learned nonuse" may all be contributing factors for the development of dysphagia in critical illness polyneuropathy. Complete recovery occurs in a high percentage of affected individuals within 4 weeks.

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Fiberoptic endoscopy evaluation of swallowing in patients with amyotrophic lateral sclerosis

Cited by 22 publications

References 14 publications

Trends in Research Literature Describing Dysphagia in Motor Neuron Diseases (MND): A Scoping Review

Trends in Research Literature Describing Dysphagia in Motor Neuron Diseases (MND): A Scoping Review

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Dysphagia—A Common, Transient Symptom in Critical Illness Polyneuropathy

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