We study the isometry group of compact spherical orientable 3-orbifolds S 3 /G, where G is a finite subgroup of SO(4), by determining its isomorphism type and, when S 3 /G is a Seifert fibrered orbifold, by describing the action on the Seifert fibrations induced by isometric copies of the Hopf fibration of S 3 . Moreover, we prove that the inclusion of Isom(S 3 /G) into Diff(S 3 /G) induces an isomorphism of the π 0 groups, thus proving the π 0 -part of the natural generalization of the Smale Conjecture to spherical 3-orbifolds.