Fiber type and citrate synthase activity in the human  gastrocnemius and vastus lateralis with aging

Houmard, Joseph A.; Weidner, M. D.; Gavigan, K. E.; Tyndall, G. L.; Hickey, Matthew S.; Alshami, Aymen

doi:10.1152/jappl.1998.85.4.1337

Cited by 134 publications

(113 citation statements)

References 27 publications

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“…One reason for these unexpected results may be the fact that aging-related loss of muscle fibers is associated with a selective atrophy of type 2 (mainly glycolytic) muscle fibers, resulting in higher relative amount of type 1 (oxidative) fibers in aged muscle (Thompson, 1994;Lexell, 1995). Hence aging-related changes in skeletal muscle, especially ones in relation to oxidative capacity, are controversially reported in the literature (Houmard et al, 1998). It may be speculated that the shift in fiber-type ratio is also affecting our results.…”

Section: Discussionmentioning

confidence: 71%

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

Karvinen

Silvennoinen

Vainio

et al. 2016

Experimental Gerontology

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Section: Discussionmentioning

confidence: 71%

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

Karvinen

Silvennoinen

Vainio

et al. 2016

Experimental Gerontology

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“…In contrast with studies of the TA, other studies have shown age-related declines in oxidative capacity of the plantarflexor muscles using both in vivo (McCully et al 1991) and in vitro approaches (e.g., enzyme activities; Coggan et al 1992;Houmard et al 1998). In the quadriceps muscles, which are most commonly studied, in vivo (Conley et al 2000;Larsen et al 2012b) and in vitro (Short et al 2005) oxidative capacities are both lower in O adults.…”

Section: Introductionmentioning

confidence: 85%

Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg

Tevald

Foulis

Kent

2014

AGE

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To determine the effects of age and sex on in vivo mitochondrial function of distinct locomotory muscles, the tibialis anterior (TA) and medial gastrocnemius (MG), of young (Y; 24±3 years) and older (O; 69±4) men (M) and women (W) of similar overall physical activity (PA) was compared. In vivo mitochondrial function was measured using phosphorus magnetic resonance spectroscopy, and PA and physical function were measured in all subjects. Overall PA was similar among the groups, although O (n=17) had fewer daily minutes of moderate-to-vigorous PA (p=0.001), and slowed physical function (p<0.05 for all variables), compared with Y (n=17). In TA, oxidative capacity (V max ; mM s −1 ) was higher in O than Y (p<0.001; Y= 0.90±0.12; O=1.12±0.18). There was no effect of age in MG (p =0.5; Y= 0.91 ± 0.17; O = 0.96 ± 0.24), but women had higher oxidative capacity than men (p= 0.007; M=0.84±0.18; W=1.03±0.18). In vivo mitochondrial function was preserved in healthy O men and women, despite lower intensity PA and physical function in this group. The extent to which compensatory changes in gait may be responsible for this preservation warrants further investigation. Furthermore, women had higher oxidative capacity in the MG, but not the TA.

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“…Differences between younger and older people in the magnitude of response in peripheral insulin sensitivity to exercise training may be explained in part by aging-related loss of muscle mass and decrements in a number of key factors related to muscle oxidative capacity in older people (6,15,23,28). Recently, Short et al (35) reported moderate-intensity (70% maximum HR), training-related improvements in insulin sensitivity that were inversely related to age, improving by 72% (P Ͻ 0.001) among younger (20 -39 yr) subjects and by 20% (P ϭ not significant) among middle-aged (40 -59 yr) subjects, but decreasing by 5% (P ϭ not significant) among people aged 60 yr or older.…”

Section: Discussionmentioning

confidence: 99%

Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training

DiPietro¹,

Dziura²,

Yeckel³

et al. 2006

Journal of Applied Physiology

220

106

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DiPietro, Loretta, James Dziura, Catherine W. Yeckel, and P. Darrell Neufer. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol 100: 142-149, 2006. First published September 1, 2005 doi:10.1152/japplphysiol.00474.2005.-Few studies have compared the relative benefits of moderate-vs. higher intensity exercise training on improving insulin sensitivity in older people while holding exercise volume constant. Healthy older (73 Ϯ 10 yr) women (N ϭ 25) who were inactive, but not obese, were randomized into one of three training programs (9-mo duration): 1) high-intensity [80% peak aerobic capacity (V O2 peak); TH] aerobic training; 2) moderate-intensity (65% V O2 peak; TM) aerobic training; or 3) low-intensity (stretching) placebo control (50% V O2 peak; CTB). Importantly, exercise volume (300 kcal/session) was held constant for subjects in both the TH and the TM groups. V O2 peak was determined by using a graded exercise challenge on a treadmill. Total body fat and lean mass were determined with dual-energy X-ray absorptiometry. The rate of insulin-stimulated glucose utilization as well as the suppression of lipolysis were determined ϳ72 h after the final exercise bout by using a two-step euglycemic-hyperinsulinemic clamp. We observed improved glucose utilization at the higher insulin dose with training, but these improvements were statistically significant only in the TH (21%; P ϭ 0.02) compared with the TM (16%; P ϭ 0.17) and CTB (8%; P ϭ 0.37) groups and were observed without changes in either body composition or V O2 peak. Likewise in the TH group, we detected a significant improvement in insulin-stimulated suppression (%) of adipose tissue lipolysis at the low-insulin dose (38 -55%, P Ͻ 0.05). Our findings suggest that long-term higher intensity exercise training provides more enduring benefits to insulin action compared with moderate-or low-intensity exercise, likely due to greater transient effects.elderly; endurance training; diabetes WHILE THERE ARE DATA SUGGESTING some degree of mandatory decline in insulin sensitivity and glucose tolerance with aging (8,19,28,35), the extent of these pathophysiological alterations is likely modulated by several other potentially confounding factors that also change with age, namely, increased adiposity, decreased lean mass, and reduced physical activity (26,31,34,39,40). Older people who exercise regularly appear to be protected from the development of insulin resistance and glucose intolerance (4,5,24,30,33), and this protection may be independent of exercise-related changes in body composition (6,9,38). However, the magnitude of improvement in insulin-stimulated glucose disposal with exercise training (performed at the same relative intensity) may be attenuated in older compared with younger people (31). This blunted response may be dependent on the absolute exercise intensity, as well as the volume (i.e., energy expenditure) of each training bout. The initial degree of insulin resistanc...

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Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging

Cited by 134 publications

References 27 publications

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg

Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training

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