Fiber Reinforced Calcium Phosphate Cement

Santos, Luís Alberto dos; Oliveira, Luciana Camargo de; Rigo, Eliana Cristina da Silva; Carrodeguas, Raúl García; Boschi, Anselmo O.; Arruda, Antônio Celso Fonseca de

doi:10.1046/j.1525-1594.2000.06541.x

Cited by 69 publications

(46 citation statements)

References 10 publications

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“…% ammonium polyacrylate to the liquid increased the compressive and tensile strength of α-TCP bone cement by 149 and 69 % (55 and 21 MPa), respectively [447]. A positive influence of polyamide fibers [448] and bioactive glass [449] is also known. Interestingly, but reinforcement of calcium orthophosphate cements might be performed by infiltration of a preset cement formulation by a reactive polymer and then cross-linking the polymer in situ [450].…”

Section: Reinforced Self-setting Formulations and Concretesmentioning

confidence: 96%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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Section: Reinforced Self-setting Formulations and Concretesmentioning

confidence: 96%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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“…Since their development in the mid-80's, CPCs have also attracted great interest due to their chemical similarity to the mineral phase of bone tissue and their good osteoconductivity 2 . One of the most important formulations is based on a-tricalcium phosphate [a-Ca 3 (PO 4 ) 2 ; a-TCP], which sets in situ and forms a calcium-deficient hydroxyapatite [Ca 9 (HPO 4 )(PO 4 ) 5 (OH); CDHA] when hydrated 3 . However, it is not very strong under compression 4 and its mechanical strength is low when compared to that of cortical bone 5 , limiting its application to areas subjected to low mechanical loads 6 .…”

Section: Introductionmentioning

confidence: 99%

“…One of the most important formulations is based on a-tricalcium phosphate [a-Ca 3 (PO 4 ) 2 ; a-TCP], which sets in situ and forms a calcium-deficient hydroxyapatite [Ca 9 (HPO 4 )(PO 4 ) 5 (OH); CDHA] when hydrated 3 . However, it is not very strong under compression 4 and its mechanical strength is low when compared to that of cortical bone 5 , limiting its application to areas subjected to low mechanical loads 6 . In view of the excellent bioresorbability of CDHA, researchers have focused their efforts on overcoming the mechanical weakness of calcium phosphate cements by using different fillers, fibers and reinforcing additives that lead to the formation of various multiphase composites, based on the idea that the filler in the matrix may eliminate crack propagation 7 .…”

Section: Introductionmentioning

confidence: 99%

Effects of silica addition on the chemical, mechanical and biological properties of a new α-Tricalcium Phosphate/Tricalcium Silicate Cement

2011

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The addition of tricalcium silicate (C 3 S) to apatite cements results in an increase of bioactivity and improvement in the mechanical properties. However, adding large amounts raises the local pH at early stages, which retards the precipitation of hydroxyapatite and produces a loss of mechanical strength. The introduction of Pozzolanic materials in cement pastes could be an effective way to reduces basicity and enhance their mechanical resistance; thus, the effect of adding silica on the chemical, mechanical and biological properties of a-tricalcium phosphate/C 3 S cement was studied. Adding silica produces a reduction in the early pH and a decrease in setting times; nevertheless, the presence of more calcium silicate hydrate (C-S-H) delays the growth of hydroxyapatite crystals and consequently, reduces early compressive strength. The new formulations show a good bioactivity, but higher cytotoxicity than traditional cements and additions higher than 2.5% of SiO 2 cause a lack of mechanical strength and an elevated degradability.

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“…Apesar do grande número de estudos, ainda não foi descrito um produto ideal para uso isolado (Santos, 2000;Moraes, 2002;Anrizeh et al, 2003;Moraes et al, 2004;Oriá, 2005). Em geral, os biomateriais não devem ter resposta do tecido hospedeiro e, para tanto, devem assemelhar-se quimicamente ao mesmo.…”

Section: Arq Bras Med Vet Zootec V65 N3 P757-762 2013unclassified

Cimento de aluminato de cálcio: uso em defeitos ósseos induzidos em fêmur de coelhos

Bürger

Moraes

Maniscalco

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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RESUMOAvaliou-se o comportamento do cimento de aluminato de cálcio em defeitos ósseos induzidos experimentalmente em fêmur de 12 coelhos Nova Zelândia Branco, distribuídos em três grupos experimentais, correspondentes aos tempos de observação pós-operatória de 15 (G15), 30 (G30) e 60 (G60) dias. Realizaram-se avaliações clínico-cirúrgicas, radiográficas e histológicas, a fim de se observar o potencial osteoindutor e osteocondutor do biomaterial no defeito ósseo, e se houve osteointegração. O cimento de aluminato de cálcio, na formulação utilizada, mostrou-se biocompatível, porém não atuou como osteocondutor ou osteoindutor.Palavras-chave: coelho, biomaterial, consolidação óssea (G60) ABSTRACT The patterns of the calcium aluminate cement in bone defects experimentally induced in the femur of 12 New Zealand White rabbits were evaluated. The animals were distributed in three experimental groups, corresponding to postoperative observation periods of 15 (G15), 30 (G30) and 60

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Fiber Reinforced Calcium Phosphate Cement

Cited by 69 publications

References 10 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Effects of silica addition on the chemical, mechanical and biological properties of a new α-Tricalcium Phosphate/Tricalcium Silicate Cement

Cimento de aluminato de cálcio: uso em defeitos ósseos induzidos em fêmur de coelhos

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