Fiber optic tunable probe for endoscopic optical coherence tomography

Aljasem, Khaled; Werber, A.; Seifert, Andreas; Zappe, Hans

doi:10.1088/1464-4258/10/4/044012

Cited by 41 publications

(25 citation statements)

References 20 publications

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“…The lengths of the rings were set so that OPD R = -20 mm. In order to superpose the two signals originating from the fundamental channel and from the first re-circulation channel, the frequency of the carrier was altered to 180 kHz to satisfy the condition (6).…”

Section: Resultsmentioning

confidence: 99%

“…In swept source (SS)-OCT imaging systems, the spectral resolution is determined by the instantaneous line-width of the swept source [5]. Narrow line-width SSs have been reported, which makes SS-OCT more suitable to imaging long axial samples than FD-OCT. Long axial range imaging is necessary in endoscopy, small animal imaging, or anterior segment imaging of the human eye where at least 1 cm axial range with good sensitivity is required [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Extra long imaging range swept source optical coherence tomography using re-circulation loops

Bradu¹,

Neagu²,

Podoleanu³

2010

Opt. Express

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Abstract:One of the main drawbacks of the swept source optical coherence tomography (SS-OCT) is its limited axial range. A novel interferometer configuration is proposed, equipped in each arm with an adjustable path length ring. By compensating the losses in the rings using semiconductor optical amplifiers, multiple paths A-scans can be obtained which when combined axially, can lead to an extremely long overall axial range. The effect of the re-circulation loops is equivalent with extending the coherence length of the swept source. In this way, the axial imaging range in SS-OCT can be pushed well beyond the limit imposed by the coherence length of the laser, to exceed in principle many centimeters. 2296-2298 (2010).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extra long imaging range swept source optical coherence tomography using re-circulation loops

Bradu¹,

Neagu²,

Podoleanu³

2010

Opt. Express

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show abstract

“…In our opinion, this could open the route for potential impacts either for future blood diagnostics and in vivo endoscopy. Recent improvement in biophotonics as the manipulation of RBCs from the outside of the vein 16 and, at the same time, new papers on the miniaturization of OT on a single fibre 17,43,44 could convincingly lead to envisage an integration of the presented technique for endoscopy. For example, it could be investigated a fibre-based system able to manipulate and trap RBCs inside the vein.…”

Section: Discussionmentioning

confidence: 99%

Red blood cell as an adaptive optofluidic microlens

et al. 2015

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The perspective of using live cells as lenses could open new revolutionary and intriguing scenarios in the future of biophotonics and biomedical sciences for endoscopic vision, local laser treatments via optical fibres and diagnostics. Here we show that a suspended red blood cell (RBC) behaves as an adaptive liquid-lens at microscale, thus demonstrating its imaging capability and tunable focal length. In fact, thanks to the intrinsic elastic properties, the RBC can swell up from disk volume of 90 fl up to a sphere reaching 150 fl, varying focal length from negative to positive values. These live optofluidic lenses can be fully controlled by triggering the liquid buffer's chemistry. Real-time accurate measurement of tunable focus capability of RBCs is reported through dynamic wavefront characterization, showing agreement with numerical modelling. Moreover, in analogy to adaptive optics testing, blood diagnosis is demonstrated by screening abnormal cells through focal-spot analysis applied to an RBC ensemble as a microlens array.

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“…These features are very important for handheld OCT device. It is well-known that the OCT reflectance is a unimodal function of focal plane position and the maximum OCT reflectance value is obtained when the sample is located at the focal plane [23]. Thus the search for the optimum focal plane becomes an extremum search problem of a unimodal function.…”

Section: Golden-section Search Based Automatic Focus Tuningmentioning

confidence: 99%

Handheld optical coherence tomography angiography

Yang

Liu

Campbell

et al. 2017

Biomed. Opt. Express

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Abstract:We developed a handheld optical coherence tomography angiography (OCTA) system using a 100-kHz swept-source laser. The handheld probe weighs 0.4 kg and measures 20.6 × 12.8 × 4.6 cm 3 . The system has dedicated features for handheld operation. The probe is equipped with a mini iris camera for easy alignment. Real-time display of the en face OCT and cross-sectional OCT images in the system allows accurately locating the imaging target. Fast automatic focusing was achieved by an electrically tunable lens controlled by a goldensection search algorithm. An extended axial imaging range of 6 mm allows easy alignment. A registration algorithm using cross-correlation to register adjacent OCT B-frames with propagation from the central frame was used to effectively minimize motion artifacts in volumetric OCTA images captured in relatively short durations of 1 and 2.1 seconds. 2.5 × 2.5 mm (200 × 200 pixels) and 3.5 × 3.5 mm (300 × 300 pixels) retinal angiograms were demonstrated on two awake adult human subjects without the use of any mydriatic eye drops. Opt. Express 4(10), 1890-1908 (2013). 40. I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G.Fujimoto, "Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with verticalcavity surface emitting lasers," Biomed.

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Fiber optic tunable probe for endoscopic optical coherence tomography

Cited by 41 publications

References 20 publications

Extra long imaging range swept source optical coherence tomography using re-circulation loops

Extra long imaging range swept source optical coherence tomography using re-circulation loops

Red blood cell as an adaptive optofluidic microlens

Handheld optical coherence tomography angiography

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