Fiber-optic particle plasmon resonance sensor for detection of interleukin-1β in synovial fluids

Chiang, Chao-Lung; Hsieh, Ming-Lung; Huang, Kuo‐Wei; Chau, Lai-Kwan; Chang, Chia‐Ming; Lyu, Shaw-Ruey

doi:10.1016/j.bios.2010.08.047

Cited by 69 publications

(56 citation statements)

References 37 publications

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“…Due to the high dielectric constant of AuNPs and electromagnetic coupling between AuNPs and the metal film on the surface, the sensitivity of the surface plasmon resonance (SPR)-based sensor can be increased. Several different materials are also used to support AuNPs such as optical fibres, ITO glass, sol-gel matrix for the detection of human IgG [50], streptavidin [51], interleukin-1β [52] and propanethiol [53]. Similarly, waveguide-mode sensor, which mimic the principle of SPR, has been generated with higher sensitive sensing using AuNP conjugation for the detection of influenza viruses [10][11][12].…”

Section: Aunp-facilitated Label-free Sensorsmentioning

confidence: 99%

Gold Nanoparticles in Biosensing Analyses

Gopinath

Citartan

Lakshmipriya

et al. 2014

Nanoparticles' Promises and Risks

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Monitoring biomolecular interactions has become a constituent element of various medical and clinical applications. The importance of measuring the biomolecular interaction is evident as a potpourri of sensing strategies is currently and continuously devised. One of the strategies that can immensely enhance the sensitivity of the interaction is the one mediated by nanoparticles. Among the various nanoparticles, gold nanoparticle (AuNP) is opted for due to its capacity to improve the sensitivity and selectivity of biomolecular interactions. In addition to this, AuNP is easy to be manufactured, chemically inert, have uniform dispersibility and are able to react with chemically modified biomolecules. In this overview, the roles adopted by AuNP in various biosensing applications are discussed.

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Section: Aunp-facilitated Label-free Sensorsmentioning

confidence: 99%

Gold Nanoparticles in Biosensing Analyses

Gopinath

Citartan

Lakshmipriya

et al. 2014

Nanoparticles' Promises and Risks

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“…61 In another study, gold NPs were shown to be coupled with a fiber-optic particle plasmon resonance technique to sense the IL-1-beta level in synovial fluids, which has a diagnostic value for osteoarthritis. 62 Nanofiber was also used to make nanofibrous scaffolds for engineered meniscus construction to increase cell survival.…”

Section: Osteoarthritismentioning

confidence: 99%

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

Wu²,

Chen³

et al. 2013

IJN

159

111

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Nanotechnology is a vigorous research area and one of its important applications is in biomedical sciences. Among biomedical applications, targeted drug delivery is one of the most extensively studied subjects. Nanostructured particles and scaffolds have been widely studied for increasing treatment efficacy and specificity of present treatment approaches. Similarly, this technique has been used for treating bone diseases including bone regeneration. In this review, we have summarized and highlighted the recent advancement of nanostructured particles and scaffolds for the treatment of cancer bone metastasis, osteosarcoma, bone infections and inflammatory diseases, osteoarthritis, as well as for bone regeneration. Nanoparticles used to deliver deoxyribonucleic acid and ribonucleic acid molecules to specific bone sites for gene therapies are also included. The investigation of the implications of nanoparticles in bone diseases have just begun, and has already shown some promising potential. Further studies have to be conducted, aimed specifically at assessing targeted delivery and bioactive scaffolds to further improve their efficacy before they can be used clinically.

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“…Typically, prism-based attenuated total reflection (ATR) SPR (Kretschmann configuration) sensor is widely employed. Such an extremely sensitive prism-based SPR sensing scheme can usually probe a 5 10 − change in the refractive index (RI) of an ambient medium, which corresponds to a mass resolution of binding molecules of about 10 pg/mm 2 [1]. This is adequate for many sensing applications, and thus the prism-based SPR sensors are now commercially available and extensively used by biochemists.…”

Section: Introductionmentioning

confidence: 99%

“…For such TOW-PPR sensor chips, the immobilized AuNPs serve as the chromophores, while their interactions with analytes will result in colorimetric changes [3,4,6,10]. Therefore, with a suitable receptor immobilized at the surface of AuNPs, the resulting TOW-PPR sensor can detect the corresponding analyte even if the analyte is spectroscopically silent in the UV-Vis region [2][3][4][5][6]10]. The presented TOW-PPR sensors are sensitive to biomolecular binding events at the nano-to pico-molar level.…”

Section: Introductionmentioning

confidence: 99%

“…However, adopting this configuration still cannot satisfy the humanized requirements of miniaturization, maneuverability, portability, inexpensiveness, and high-throughput detection, because a bulky, expensive, and sophisticated optical setup is necessary. Recently, Chau and coworkers [2][3][4][5][6] demonstrated that fiber optic particle plasmon resonance (FO-PPR) sensors allow for a small sensing element and sample volume, simplified optical design, and the possibility of disposable FO-PPR sensor chips. This fiber optic evanescent wave sensor was constructed on the basis of modification of the unclad portion of an optical fiber with self-assembled gold nanoparticles (AuNPs).…”

Section: Introductionmentioning

confidence: 99%

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Tubular optical waveguide-based particle plasmon resonance biosensor for label-free and real-time detection

et al. 2012

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A novel tubular optical waveguide-based particle plasmon resonance (TOW-PPR) device for chemical and biochemical sensing is presented. The sensor is based on intensity measurement of consecutive total internal reflections (TIRs) along the wall of the gold nanoparticles-modified glass vial at a fixed wavelength from a miniaturized light emitting diode (LED). The extinction cross-section of self-assembled gold nanoparticles on the inner wall surface of a tubular glass vial changes with different refractive indexes (RIs) of surroundings in the vicinity of nanoparticles. In comparison with other evanescent wave based optical sensors, the TOW-PPR sensor possesses merits of being a wavelength-selectable optical waveguide sensor to fit application needs, microchamber of a defined sample volume, and itself of being a mechanical support for sensor coatings. The sensor resolution is estimated to be 6 10 7 . 2 − × RIU in measuring solutions of various RIs ranging from 1.343 to 1.403 obtained by dissolving sucrose in ultrapure water with a concentration between 6.8% and 41.7%. Moreover, the TOW-PPR microchamber was chemically modified with N-(2,4-dinitrophenyl)-6-aminohexanoic acid (DNP, MW = 297.27 Da) and has been shown to be able to detect different concentrations of antidinitrophenyl antibody (anti-DNP, MW = 220 kDa) in buffer solutions. From corresponding calibrations, a detection limit of 10 10 21 . 1 − × g/ml by DNP-functionalized TOW-PPR sensor chip for anti-DNP detection is demonstrated. The device can be simply and inexpensively fabricated, and therefore is ideally suitable for disposable plasmonic sensors, especially promising for high-throughput biochemical sensing applications.

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Fiber-optic particle plasmon resonance sensor for detection of interleukin-1β in synovial fluids

Cited by 69 publications

References 37 publications

Gold Nanoparticles in Biosensing Analyses

Gold Nanoparticles in Biosensing Analyses

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

Tubular optical waveguide-based particle plasmon resonance biosensor for label-free and real-time detection

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