Fiber-optic coupler based refractive index sensor and its application to biosensing

Tazawa, Hidehisa; Kanie, Tomohiko; Katayama, M.

doi:10.1063/1.2783278

Cited by 98 publications

(56 citation statements)

References 13 publications

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“…Interaction of target agents with antibodies immobilised on the sensing surface results in localised changes in refractive index, which manifests as changes in the colour of reflected light. [11,12], interferometers [13], ring-resonators [14], photonic crystals [15], fibre-optics [16] and planar optical waveguides [9,17]. Advantages of optical sensors encompass immunity to electromagnetic interference, remote sensing capability, intrinsic safety and the ability to provide multiplexed detection within a single device.…”

Section: Introductionmentioning

confidence: 99%

Multi-purpose optical biosensors for real-time detection of bacteria, viruses and toxins

Bhatta

Stadden

Hashem

et al. 2010

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 99%

Multi-purpose optical biosensors for real-time detection of bacteria, viruses and toxins

Bhatta

Stadden

Hashem

et al. 2010

Sensors and Actuators B: Chemical

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“…3 times lower LoD that sensor prepared using sputtering. It should be noted that both values are similar to or better than other optical fibre devices [7,[49][50][51].…”

Section: Andmentioning

confidence: 84%

Novel Highly Sensitive Protein Sensors Based on Tapered Optical Fibres Modified with Au-Based Nanocoatings

et al. 2016

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Novel protein sensors based on tapered optical fibres modified with Au coatings deposited using two different procedures are proposed. Au-based coatings are deposited onto a nonadiabatic tapered optical fibre using (i) a novel facile method composed of layer-by-layer deposition consisting of polycation (poly(allylamine hydrochloride), PAH) and negatively charged SiO 2 nanoparticles (NPs) followed by the deposition of the charged Au NPs and (ii) the sputtering technique. The Au NPs and Au thin film surfaces are then modified with biotin in order to bind streptavidin (SV) molecules and detect them. The sensing principle is based on the sensitivity of the transmission spectrum of the device to changes in the refractive index of the coatings induced by the SV binding to the biotin. Both sensors showed high sensitivity to SV, with the lowest measured concentration levels below 2.5 nM. The calculated binding constant for the biotin-SV pair was 2.2 × 10 −11 M −1 when a tapered fibre modified with the LbL method was used, with a limit of detection (LoD) of 271 pM. The sensor formed using sputtering had a binding constant of 1.01 × 10with a LoD of 806 pM. These new structures and their simple fabrication technique could be used to develop other biosensors.

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“…It is well known that the spectral characteristics of the fused fiber coupler are affected by the external medium surrounding the fused region of the coupler due to an evanescent wave [8,9]. This article presents the spectral characteristics of the fused fiber tunable coupler, which have been experimentally obtained at various conditions.…”

Section: Introductionmentioning

confidence: 97%

Empirical Analysis of Widely Tunable Fused Fiber Coupler Assisted by External Medium of High Thermo-Optic Coefficient

Kim

Cho

Lee

2011

Fiber and Integrated Optics

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This article reports the fused fiber coupler whose transmission spectrum is widely tuned or switched with temperature. With a proper choice of the external medium applied on the fused region of the coupler, the tuning range could be expanded up to the free spectral range of the coupler itself. A polymer with a matched refractive index and high thermo-optic coefficient was used as the external medium, and a microcoil heater was installed to tune or switch the coupler. As the elongation length of the coupler increased in the fabrication process, the tuning range increased also. With the polymer having a thermo-optic coefficient of 1:8 10 4 = ı C and a 1.440 room temperature refractive index, wavelength tuning as wide as 210 nm was experimentally obtained. The fabrication process of the tunable fused coupler and the temperaturedependent spectral properties of the implemented couplers in terms of the elongation length and the polymer index are presented in detail. The feasibility of the proposed device as a tunable filter, optical switch, and variable optical attenuator are also presented.

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Fiber-optic coupler based refractive index sensor and its application to biosensing

Cited by 98 publications

References 13 publications

Multi-purpose optical biosensors for real-time detection of bacteria, viruses and toxins

Multi-purpose optical biosensors for real-time detection of bacteria, viruses and toxins

Novel Highly Sensitive Protein Sensors Based on Tapered Optical Fibres Modified with Au-Based Nanocoatings

Empirical Analysis of Widely Tunable Fused Fiber Coupler Assisted by External Medium of High Thermo-Optic Coefficient

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