Infrared spectroscopy is a powerful tool for basic and applied science. The molecular "spectral fingerprints" in the 3 µm to 20 µm region provide a means to uniquely identify molecular structure for fundamental spectroscopy, atmospheric chemistry, trace and hazardous gas detection, and biological microscopy. Driven by such applications, the development of low-noise, coherent laser sources with broad, tunable coverage is a topic of great interest. Laser frequency combs possess a unique combination of precisely defined spectral lines and broad bandwidth that can enable the above-mentioned applications.Here, we leverage robust fabrication and geometrical dispersion engineering of silicon nanophotonic waveguides for coherent frequency comb generation spanning 70 THz in the mid-infrared (2.5 µm to 6.2 µm). Precise waveguide fabrication provides significant spectral broadening and engineered spectra targeted at specific mid-infrared bands. We use this coherent light source for dual-comb spectroscopy at 5 µm.Spectroscopy has been a primary scientific tool for studying nature, leading to seminal advances in astronomy, quantum physics, chemistry and biology. The coherent light from a laser provides a powerful spectroscopic tool with the properties of high spectral resolution, wavelength tunability, and a well-defined Gaussian beam enabling high intensity focusing and long-distance propagation. Frequency comb lasers combine the above qualities in addition to a broad spectrum of precisely defined optical lines (the "comb") that can be absolutely referenced to radio frequencies (RF) or atomic frequency standards 1-3 . This has led to a variety of new spectroscopic advances 4-13 .While frequency combs were initially developed for the visible and near-infrared spectral regions, more recent research has focused on extending their coverage to the mid-infrared (mid-IR) 14 . This spectral region is of great interest because it is where many molecules including greenhouse gases, poisonous agents, explosives, and organics show distinctive ro-vibrational absorption fingerprints 14 . The development of a practical, broadband, and low-noise mid-IR frequency comb with moderate power could dramatically improve frequency precision, sensitivity, and data acquisition rates compared to conventional techniques such as Fourier-