Fiber-Optic Biosensor to Detect pH and Glucose

Khan, Md. Rajibur Rahaman; Watekar, Apurva Vinodrao; Kang, Shin‐Won

doi:10.1109/jsen.2017.2786279

Cited by 45 publications

(28 citation statements)

References 47 publications

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“…One of the most common linkers is MUA which has a thiol group to attach on gold and carboxyl groups to further bind the ligand. Carboxyl groups on MUA can further be activated by incubating the surface with EDC and NHS before incubation with antibodies as was shown in different studies 38 , 77 , 78 . AFM is very useful in determining nanoscale changes on the modified surfaces 66 .…”

Section: Discussionmentioning

confidence: 96%

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Bekmurzayeva

Ashikbayeva

Myrkhiyeva

et al. 2021

Sci Rep

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Increased level of CD44 protein in serum is observed in several cancers and is associated with tumor burden and metastasis. Current clinically used detection methods of this protein are time-consuming and use labeled reagents for analysis. Therefore exploring new label-free and fast methods for its quantification including its detection in situ is of importance. This study reports the first optical fiber biosensor for CD44 protein detection, based on a spherical fiber optic tip device. The sensor is easily fabricated from an inexpensive material (single-mode fiber widely used in telecommunication) in a fast and robust manner through a CO2 laser splicer. The fabricated sensor responded to refractive index change with a sensitivity of 95.76 dB/RIU. The spherical tip was further functionalized with anti-CD44 antibodies to develop a biosensor and each step of functionalization was verified by an atomic force microscope. The biosensor detected a target of interest with an achieved limit of detection of 17 pM with only minor signal change to two control proteins. Most importantly, concentrations tested in this work are very broad and are within the clinically relevant concentration range. Moreover, the configuration of the proposed biosensor allows its potential incorporation into an in situ system for quantitative detection of this biomarker in a clinical setting.

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Section: Discussionmentioning

confidence: 96%

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Bekmurzayeva

Ashikbayeva

Myrkhiyeva

et al. 2021

Sci Rep

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“…Khan manufactured an optical fiber coated with gold nanoparticles; he selected a single mode fiber 70 mm long, with core and cladding diameters of approximately 3 µm and 125 µm, respectively. Later 10 mm of cladding was removed from one end, thereby creating a tip, which is cleaned with ethanol, methanol and deionized water and then dried with N2 gas, obtaining results at 820 to 920 nm and having a response time of 8 to 9 s in each measurement, with a sensitivity of 3.25 nm/mM [100]. Chen proposed a U-shaped fiber optic sensor made using a flame heating method.…”

Section: Single-mode Fiber Optic Sensorsmentioning

confidence: 99%

Fiber Optic Sensors: A Review for Glucose Measurement

et al. 2021

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Diabetes mellitus is a chronic metabolic disorder, being globally one of the most deadly diseases. This disease requires continually monitoring of the body’s glucose levels. There are different types of sensors for measuring glucose, most of them invasive to the patient. Fiber optic sensors have been proven to have advantages compared to conventional sensors and they have great potential for various applications, especially in the biomedical area. Compared to other sensors, they are smaller, easy to handle, mostly non-invasive, thus leading to a lower risk of infection, high precision, well correlated and inexpensive. The objective of this review article is to compare different types of fiber optic sensors made with different experimental techniques applied to biomedicine, especially for glucose sensing. Observations are made on the way of elaboration, as well as the advantages and disadvantages that each one could have in real applications.

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“…A combined pH and glucose sensor was developed using pH sensitive and solvatochromic dyes deposited on a gold nanoparticle coated unclad, straight fiber-optic probe. [38] A singlemode optical fiber was used with core and cladding diameters of approximately 3 μm and 125 μm, respectively. A fraction of the evanescent radiation from the core mode penetrated into the gold nanoparticle layer and was reflected.…”

Section: Biosensing With Non-resonant Structures On De-cladded Fibers: Biomolecules Detectionmentioning

confidence: 99%

“…[166] Copyright 2017, Springer Nature. Glucose (sensitivity = 3.25 nm mM -1 and linear stability over 1 µM -1 M) [38] Heat-pulling to form a tapered waveguide Glucose (13.04 nm total resonance shift for 260 mg dl -1 analyte) [47] Stripping CRP (sensitivity = 1.17 nm µg -1 mL and linear response for concentrations ranging [52] This article is protected by copyright. All rights reserved.…”

Section: Concluding Remarks and Outlookmentioning

confidence: 99%

Advances in Fiber‐Optic Technology for Point‐of‐Care Diagnosis and In Vivo Biosensing

Tabassum

Kumar

2020

Adv Materials Technologies

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Development of reliable, sensitive, selective, and miniaturized sensing technologies is critical for health assessment and early diagnosis and treatment of diseases/anomalies while simultaneously mitigating the challenges associated with in vivo measurements. Some critical constraints to the realization of in vivo measurements include the necessity to fabricate the sensor on a tightly constrained footprint while ensuring acceptable biocompatibility, accuracy, and reliability. The inherent light-guiding properties of optical fibers over long distances, their microscopic cross-section that can be structured at the nanoscale to manipulate the light transmittance/reflectance spectrum, excellent biocompatibility enabling their efficient integration with bio-recognition molecules, immunity to electromagnetic interference, mechanical flexibility, and low cost have been inviting research attention to utilize these unique features for in vivo and label-free point-ofcare diagnostics. Hence, fiber-optic biosensing has become a promising research thrust, with a plethora of emerging methodologies to develop ultrasensitive and selective sensing probes.A unified presentation of the research trends on biosensors incorporated into optical fibers is presented.

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Fiber-Optic Biosensor to Detect pH and Glucose

Cited by 45 publications

References 47 publications

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Fiber Optic Sensors: A Review for Glucose Measurement

Advances in Fiber‐Optic Technology for Point‐of‐Care Diagnosis and In Vivo Biosensing

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