Fiber-optic biochemical sensing with a colloidal gold-modified long period fiber grating

Tang, Jaw-Luen; Cheng, Shu-Fang; Hsu, Wei-Ting; Chiang, Tsung‐Yu; Chau, Lai-Kwan

doi:10.1016/j.snb.2005.12.003

Cited by 115 publications

(64 citation statements)

References 10 publications

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“…Since the discovery of fiber gratings, the use of FBGs and LPGs for external RI sensing was proposed and demonstrated because of their potential applications as miniature biochemical sensors [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. The detection of a specific antibody or antigen was demonstrated after immobilization of biological molecules or antibody on the surface of fiber grating [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…The detection of a specific antibody or antigen was demonstrated after immobilization of biological molecules or antibody on the surface of fiber grating [8][9][10][11][12]. An FBG needs some special post-processes for sensing of external RI [13][14][15], and has practical implementation limitations, including the reduction on the sensor's mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective  fiber end-face mirror

Meng¹,

Zhang²,

Wang³

et al. 2009

Opt. Express

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A long-period grating (LPG) based compact optical fiber sensor working in reflection mode is demonstrated. A technique to make a mirror on the cladding region of a fiber end-face to reflect only the cladding modes was realized by growing a polymeric microtip on the core region of the fiber end-face, by photopolymerization, followed by coating the fiber end-face with an aluminum film. Using the cladding-mode-selective fiber end-face mirror, the transmission spectrum of the LPG was "inverted" and reflected. Preliminary results of using the sensor to measure the refractive index of glycerol/water solutions were successfully demonstrated.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective  fiber end-face mirror

Meng¹,

Zhang²,

Wang³

et al. 2009

Opt. Express

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“…To the best of our knowledge, this work presents the first DNA and bacteria sensors using the FLRD technique. Without utilizing additional optical components, such as an FBG or LPG to fabricate the sensor head, as reported in recent studies, [6][7][8][9][10] our sensor design demonstrates comparable or better performance while featuring significantly lower cost, simplified design and configuration, and potentially higher detection sensitivity. Figure 1(a) shows the fiber loop ringdown system consisting of a section of fused-silica single mode fiber (SMF 28, Corning, Inc.), two identical 2×1 fiber couplers (Opneti Communication), a temperature-controlled continuous wave diode laser with output power of 30 mW when operating at 100 mA (NEL America), an InGaAs photodetector (Thorlabs, PDA50B), and an electronic control.…”

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confidence: 55%

Fiber loop ringdown DNA and bacteria sensors

et al. 2011

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Abstract. We report a new type of refractive index-based biosensor using a fiber loop ringdown evanescent field (FLRD-EF) sensing scheme, in which the sensing signal is a time constant and detection sensitivity is enhanced by the multipass nature of the ringdown technique. Bulk index-based detections of three different single strand DNAs and one type of bacteria are demonstrated for the FLRD-EF sensors that utilize a partially-etched single mode fiber as the sensor head. Stepwise coating of the sensor head with poly-L-lysine and a probe DNA has enabled surface index-based label-free target DNA sensing. We expect an array of FLRD-EF biosensors to be created, which are superior to counterparts in terms of simplicity, low cost, and high sensitivity. C FLRD as a uniform time-domain sensing scheme has been explored to develop a variety of physical and chemical fiber optics sensors, such as pressure, strain, temperature, refractive index, microfluids, and volatile organic compounds; the details can been read in recent reviews. 3,4 In FLRD, the sensing signal is a time constant; the detection sensitivity is proportionally enhanced by the number of round-trips a laser pulse travels in the fiber loop which can be up to a few kilometers long. Many sensing mechanisms, such as direct gas absorption, microbending-induced deformation, fiber Bragg grating (FBG)-and long period grating (LPG)-based wavelength shift, and evanescent field (EF) absorption and scattering, can be directly adopted into the uniform sensing platform for the development of different sensors. This technique has great potential for biosensor development, yet it has not been much explored, except for one early publication in which a single mammalian cancer cell is detected based on the scattering effect of the localized EF around a 10-mm long single mode fiber taper. 5In this work, we demonstrate bulk index-based deoxyribonucleic acid (DNA) and bacteria sensing and surface index-based label-free DNA sensing using the FLRD sensing scheme combined with the EF sensing mechanism. To the best of our knowledge, this work presents the first DNA and bacteria sensors using the FLRD technique. Without utilizing additional optical components, such as an FBG or LPG to fabricate the sensor head, as reported in recent studies, 6-10 our sensor design demonstrates comparable or better performance while featuring significantly lower cost, simplified design and configuration, and potentially higher detection sensitivity. Figure 1(a) shows the fiber loop ringdown system consisting of a section of fused-silica single mode fiber (SMF 28, Corning, Inc.), two identical 2×1 fiber couplers (Opneti Communication), a temperature-controlled continuous wave diode laser with output power of 30 mW when operating at 100 mA (NEL America), an InGaAs photodetector (Thorlabs, PDA50B), and an electronic control. Cladding and core diameters of the single mode fiber are 125 and 8 μm, respectively. The total optical loss, including the absorption loss, fiber connectors' insertion losses, and fi...

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“…Reprinted from [124] with permission from Elsevier advances have allowed obtaining optical fiber sensors based on localized surface plasmon resonances (LSPR) from metallic-nanoparticles thin films [9,107]. This kind of sensors is acquiring particular relevance in the field of optical fiber sensing and biosensing [120,122,[125][126][127][128][129]. As an example, in Fig.…”

Section: Metallic Nano Thin Filmsmentioning

confidence: 99%

Fiber Optic Sensors Based on Nanostructured Materials

Elosúa

Hernáez

Matı́as

et al. 2014

Springer Series in Surface Sciences

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Fiber optic sensors have been developed taking advantage on the synergy between the properties of nanostructured materials and the ones that characterize an optical fiber. The mechanical properties of optical fiber introduce some restrictions to the techniques used for the deposition of materials. As an alternative to the classical deposition procedures, wet coating techniques have been successfully applied in these cases. The current chapter put emphasis on materials that can be incorporated using wet coating techniques. The first one presented is the multilayer based nanostructures: among the different alternatives, we have focused on materials prepared with the Layer-by-Layer technique. Another type of products used for the fabrication of optical fiber sensors is sol-gel matrices, which are made of silica, so that its optical properties are similar to the ones of an optical fiber. The other two described type of products have focused the attention of many researchers in the recent years. Firstly, materials with an enhanced selectivity are presented: the molecularly imprinted polymers (MIPs). Finally, sensors based on metallic nanolayers and particles are presented. All these materials and techniques have acquired a great importance in the field of optical fiber sensors due to their versatility and the good features that offer.

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Fiber-optic biochemical sensing with a colloidal gold-modified long period fiber grating

Cited by 115 publications

References 10 publications

Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective  fiber end-face mirror

Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective  fiber end-face mirror

Fiber loop ringdown DNA and bacteria sensors

Fiber Optic Sensors Based on Nanostructured Materials

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Fiber-optic biochemical sensing with a colloidal gold-modified long period fiber grating

Cited by 115 publications

References 10 publications

Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective fiber end-face mirror

Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective fiber end-face mirror

Fiber loop ringdown DNA and bacteria sensors

Fiber Optic Sensors Based on Nanostructured Materials

Contact Info

Product

Resources

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Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective  fiber end-face mirror

Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective  fiber end-face mirror