Fiber-Optic-Based Biosensor as an Innovative Technology for Point-of-Care Testing Detection of Foodborne Pathogenic Bacteria To Defend Food and Agricultural Product Safety

Gu, Ronghui; Lin, Qingyu; Li, Yongxin; Luo, Zewei

doi:10.1021/acs.jafc.3c02067

Cited by 20 publications

(5 citation statements)

References 30 publications

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“…Other biosensors whose sensitivity was reported in terms of CFU/mL, actually register DNA, and from the average size of which the number of bacteria can be calculated [24]. Given the danger of food contamination with H. pylori, on-site control by biosensors is extremely important, as highlighted in [25].…”

Section: Biosensorsmentioning

confidence: 99%

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SPR and Double Resonance LPG Biosensors for Helicobacter pylori BabA Antigen Detection

Dyankov,

Eftimov,

Hikova

et al. 2024

Sensors

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Given the medical and social significance of Helicobacter pylori infection, timely and reliable diagnosis of the disease is required. The traditional invasive and non-invasive conventional diagnostic techniques have several limitations. Recently, opportunities for new diagnostic methods have appeared based on the recent advance in the study of H. pylori outer membrane proteins and their identified receptors. In the present study we assess the way in which outer membrane protein–cell receptor reactions are applicable in establishing a reliable diagnosis. Herein, as well as in other previous studies of ours, we explore the reliability of the binding reaction between the best characterized H. pylori adhesin BabA and its receptor, the blood antigen Leb. For the purpose we developed surface plasmon resonance (SPR) and double resonance long period grating (DR LPG) biosensors based on the BabA–Leb binding reaction for diagnosing H. pylori infection. In SPR detection, the sensitivity was estimated at 3000 CFU/mL—a much higher sensitivity than that of the RUT test. The DR LPG biosensor proved to be superior in terms of accuracy and sensitivity—concentrations as low as 102 CFU/mL were detected.

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Section: Biosensorsmentioning

confidence: 99%

“…The sensing platform used was a previously described [25,26] double resonance long period fiber grating (DR LPG). Such a grating is highly sensitive to the surrounding refractive index changes.…”

Section: Double Resonance Long Period Gratings (Dr Lpg)mentioning

confidence: 99%

SPR and Double Resonance LPG Biosensors for Helicobacter pylori BabA Antigen Detection

Dyankov,

Eftimov,

Hikova

et al. 2024

Sensors

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show abstract

“…Additionally, patients can engage in flexible self‐monitoring, empowering them to better understand and manage their conditions. Due to its rapid analysis and easy operation, POCT has been widely adopted in various fields such as medical care, 3–5 environmental monitoring 6,7 and food safety 8,9 . The paradigm shift in modern medical practices has steered hospitals from mere therapeutic endeavors toward comprehensive, systematized healthcare systems encompassing prevention, wellness, treatment, and rehabilitation, thereby furnishing society with all‐encompassing, high‐quality services.…”

Section: Introductionmentioning

confidence: 99%

Intelligent point of care testing for medicine diagnosis

Gao,

2024

Interdisciplinary Medicine

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Intelligent point‐of‐care testing (iPOCT) is a rapidly advancing technology that combines molecular detection and bio‐sensing techniques to achieve instant and accurate analysis through advanced sensors and intelligent algorithms. Molecular detection technologies, such as nucleic acid isothermal amplification, biochip and microfluidics, enable rapid analysis of the chemical composition and concentration of samples, thereby determining their presence. Bio‐sensing technology utilizes the recognition properties of biomolecules in conjunction with sensors to detect specific biomolecules or biological processes. iPOCT technology holds broad prospects for application in the field of healthcare and is expected to enhance detection sensitivity, accuracy, and intelligence through further development. In this review, we delineate the developmental journey of iPOCT, followed by a discussion on the principles of molecular detection and bio‐sensing technology, as well as the design of iPOCT devices for health monitoring and disease diagnosis. Furthermore, we showcased illustrative examples of iPOCT applications in disease diagnosis, highlighting the integration of iPOCT technology with wearable devices and smartphones for attaining more precise and personalized diagnostic results.

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“…The current biosensors focus on the detection of one or more certain disease biomarkers that accurately reflect the state of the disease for in vitro diagnosis. The global epidemic of COVID together with other diseases of cancer and foodborne disease put in evidence the excellent demand for the rapid, accurate, simple, and large‐scale scanning or diagnosis in vitro, also called “POCT” 2–4 . it needs to be more accurate than clinical diagnosis relying on the bits of the biomarkers due to the significant individual variability.…”

Section: Introductionmentioning

confidence: 99%

Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy

Luo,

Li,

Kong

et al. 2023

Interdisciplinary Medicine

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Precision medicine that takes individual variability into account is a new way to minimize the individual variability for precise diagnosis and to establish the certain strategies of efficient therapy. Due to miniaturization sensing area, remoting detection, and flexible operation of light, fiber optics have been successfully used to develop in vitro, wearable, and implanted biosensors, exhibiting high potential in precision medicine from the diagnosis in vitro to therapy in vivo. When modified with the recognition element, the fiber optic‐based biosensor enables the point of care testing for the detection of disease biomarkers. Meanwhile, the fiber optics packaged in a needle/catheter also monitor the medical Internet of things for the continuous assessment of human health. Moreover, the light from the cladding or leaky mode in the fiber optics excites the strong photothermal effect for therapy. The fiber optic‐based biosensor addressed the drawbacks of plasmonic photothermal therapy that limited penetration depths and non‐selectivity therapy. When integrated with a photothermal agent, the fiber optic‐based biosensors provide in situ information for the diagnosis as well as specifically and efficiently kill the tumor cells in deep tissues. In this review, we summarized the advances of fiber optic‐based biosensors in the diagnosis in vitro and therapy in vivo. The challenges and prospection of the fiber optic‐based biosensor application in precision medicine were also explored in depth.

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Fiber-Optic-Based Biosensor as an Innovative Technology for Point-of-Care Testing Detection of Foodborne Pathogenic Bacteria To Defend Food and Agricultural Product Safety

Cited by 20 publications

References 30 publications

SPR and Double Resonance LPG Biosensors for Helicobacter pylori BabA Antigen Detection

SPR and Double Resonance LPG Biosensors for Helicobacter pylori BabA Antigen Detection

Intelligent point of care testing for medicine diagnosis

Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy

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