Fiber growth initiation in hair follicles of goats treated with melatonin

Nixon, A. J.; Choy, V. J.; Parry, A. L.; Pearson, A. J.

doi:10.1002/jez.1402670108

Cited by 50 publications

(42 citation statements)

References 16 publications

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“…Thus, animals fed with a melatonin-supplemented diet showed an increased rate of hair growth in springtime, the period of change from the winter coat to summer fur ( 51 ). The results were independently confirmed in other experimental models ( 52,53 ). The fur growth may be mediated by melatonin binding sites/receptors, because these were identified in the rodent skin ( 19,54,55 ).…”

Section: Phenotypic Effects Of Melatoninsupporting

confidence: 78%

On the Role of Melatonin in Skin Physiology and Pathology

Słomiński

Fischer

Żmijewski

et al. 2005

ENDO

228

281

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Melatonin has been experimentally implicated in skin functions such as hair growth cycling, fur pigmentation, and melanoma control, and melatonin receptors are expressed in several skin cells including normal and malignant keratinocytes, melanocytes, and fibroblasts. Melatonin is also able to suppress ultraviolet (UV)-induced damage to skin cells and shows strong antioxidant activity in UV exposed cells. Moreover, we recently uncovered expression in the skin of the biochemical machinery involved in the sequential transformation of L-tryptophan to serotonin and melatonin. Existence of the biosynthetic pathway was confirmed by detection of the corresponding genes and proteins with actual demonstration of enzymatic activities for tryptophan hydroxylase, serotonin Nacetyl-transferase, and hydroxyindole-O-methyltransferase in extracts from skin and skin cells. Initial evidence for in vivo synthesis of melatonin and its metabolism was obtained in hamster skin organ culture and in one melanoma line. Therefore, we propose that melatonin (synthesized locally or delivered topically) could counteract or buffer external (environmental) or internal stresses to preserve the biological integrity of the organ and to maintain its homeostasis. Furthermore, melatonin could have a role in protection against solar radiation or even in the management of skin diseases.

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Section: Phenotypic Effects Of Melatoninsupporting

confidence: 78%

On the Role of Melatonin in Skin Physiology and Pathology

Słomiński

Fischer

Żmijewski

et al. 2005

ENDO

228

281

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“…This indicates that, in the New Zealand cashmere goat, there is a more distinct autumn moult, as in the mink (AUain et al 1981). In accordance, Nixon et al, (1993) observed an induction of proanagen, the first stage of the initiation of activity, in response to a smaU decrease in circulating prolactin concentration, foUowing melatonin administration in the spring. Initially, this appears to be contradictory to the results presented above; however, this response to a decrease in prolactin concentration can be likened to the induction of winter coat growth, in the autumn, as demonstrated in the mink (Allain et al 1981).…”

supporting

confidence: 78%

“…Telogen foUicles were identified by the lack of a distinct inner root sheath, and a darker staining of the nuclei in the outer root sheath which appear to point inwards. For detaUed descriptions of the sequence of structural changes in the hair follicle cycle see Nixon et al (1993), Chase (1958) …”

Section: Histologymentioning

confidence: 99%

The role of prolactin in the reactivation of hair follicles in relation to moulting in cashmere goats

Dicks¹,

Russel²,

Lincoln³

1994

Journal of Endocrinology

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The effects of the suppression or elevation of plasma prolactin concentrations in spring on the timing of the reactivation of the hair follicles and the timing of the spring moult were investigated in cashmere goats. Thirty eight adult female goats, housed under conditions of natural photoperiod at 55 degrees 55'N from mid-December until May, were allocated to four groups starting on 5 January: ten served as untreated controls, eight received 2 mg ovine prolactin subcutaneously every 12 h for 7 weeks (PRL), twelve received 35 mg bromocriptine intramuscularly every 14 days for 17 weeks (BCR) and eight received injections of both ovine prolactin and bromocriptine at the above dose rates for 7 weeks (PRL+BCR). In the PRL group there was an earlier reactivation of the secondary hair follicles (PRL vs control, proportion of secondary follicles in antigen, weeks 1-5, P < 0.01) associated with an earlier moult of secondary fibres (cashmere) but no significant difference in the activity of the primary hair follicles. In the BCR group there was a delay in the reactivation of both the secondary and primary hair follicles (BCR vs control, proportion of secondary and primary hair follicles in anagen, weeks 5-13, P < 0.01) and a delay in the moult. In the PRL+BCR group there was an early reactivation and moult similar to the PRL group. Voluntary food intake (VFI) and liveweight were also measured. Only in the BCR group was there a decrease in VFI compared with the controls but with no effect on liveweight.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Fixed samples were then processed overnight through graded concentrations of ethanol in an automatic tissue processor, embedded in paraffin polymer wax blocks, and sectioned at 7 μm. Section ribbons were floated in a water bath at 38-40°C and captured on glass slides that were coated with an albumin solution and stained by the Sacpic method [23] to determine the follicle characteristics.…”

Section: Sample Collections and Preparationsmentioning

confidence: 99%

Effect of Different Levels of Copper and Molybdenum Supplements on Performance, Nutrient Digestibility, and Follicle Characteristics in Cashmere Goats

Zhang

Zhu

et al. 2011

Biol Trace Elem Res

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A 2 × 3 factorial arrangement of treatments was used to investigate the effects of different levels of copper (Cu, 0, 19, and 38 mg/kg, dry matter (DM)) and molybdenum (Mo, 0 and 5 mg/kg, DM) supplements and an interaction of these two factors on growth performance, nutrient digestibility, and cashmere and follicle characteristics in cashmere goats. Thirty-six Liaoning cashmere goats (approximately 1.5 years of age; 27.53 ± 1.38 kg of body weight) were assigned randomly to one of six treatments and fed with Chinese wildrye- and alfalfa hay-based treatment diets (the basal diet contained 4.72 mg Cu/kg, 1.65 mg Mo/kg, and 0.21% S.). Body weight was measured on two consecutive days at the start and the end of the 70-day experimental period. On day 30, the metabolism trial was conducted to study the effects of dietary Cu and Mo on nutrient digestibility. The cashmere and skin samples were collected on day 70. Copper supplementation increased (P < 0.05) growth performance and fiber digestion, but there were no differences (P > 0.05) between Cu-supplemented groups. Addition of 19 mg Cu/kg DM increased (P < 0.05) cashmere growth length or growth rate by increasing the number of active secondary follicles. Molybdenum supplementation decreased (P < 0.05) growth, but did not affect (P > 0.05) nutrient digestion, cashmere, and follicle characteristics. There is a tendency or significant interaction effect of Cu and Mo on growth performance (P = 0.057), cashmere growth (P = 0.076), or diameter (P < 0.05) which might be accomplished by changing the number of secondary follicle and active secondary follicle, and secondary to primary follicle ratio. In conclusion, the optimal supplemental Cu level for Liaoning cashmere goats fed with the basal diet was 19 mg/kg DM (the total dietary Cu level of 23.72 mg/kg DM), while 38 mg Cu/kg DM supplementation was found to be needed when 5 mg Mo/kg was added in the basal diet during the cashmere growing period.

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Fiber growth initiation in hair follicles of goats treated with melatonin

Cited by 50 publications

References 16 publications

On the Role of Melatonin in Skin Physiology and Pathology

On the Role of Melatonin in Skin Physiology and Pathology

The role of prolactin in the reactivation of hair follicles in relation to moulting in cashmere goats

Effect of Different Levels of Copper and Molybdenum Supplements on Performance, Nutrient Digestibility, and Follicle Characteristics in Cashmere Goats

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