Fiber diameter, porosity and functional group gradients in electrospun scaffolds

Abstract

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Visualization of porosity and pore size gradients in electrospun scaffolds using laser metrology

“…Common remedies include the use of salt-based porogens [1][2][3][4] or sacrificial fibers [1,2,5,6] that should create the space needed for cell ingress and tissue development. More recently, complex gradients are being engineered into state-of-the-art scaffolds [7][8][9][10][11][12] to more closely mimic biological structures or to enable high-throughput screening. Despite these advances, characterization methods that provide comprehensive, spatially-resolved quantification of porosity are still lacking.…”

Cell-Instructive Surface Gradients of Photoresponsive Amyloid-like Fibrils

“…A two-dimensional map of the epitope-presenting substrate was achieved and cells adjusted their adhesion behavior according to the density of the RGD-epitope on the substrate (Scheme ). This versatile platform could be employed for bio and tissue engineering, in which spatial control over cell growth can be achieved on an anisotropic distribution of bioactive molecules, mimicking the ECM in certain aspects. − …”

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

“…Recently, Zonderland added functionalized poly(ethylene glycol) additives to the polymer solution to create a scaffold with an in-depth gradient of functional groups, which can potentially be used in a wide variety of polymer solutions to couple peptides and proteins to electrospun scaffolds. 116 Surface coating is another common method. It has been reported that fibers coated with natural materials could exhibit better biological behaviors such as infiltration and homogeneous distribution of cells 117,118 and show potential for periodontal ligament regeneration.…”