Fiber burden and asbestos-related diseases: an umbrella review

Ramada, José María; Cerrada, Beatriz Calvo; Pujadas, Consol Serra; Delclos, George L.; Benavides, Fernando G.

doi:10.1016/j.gaceta.2021.04.001

Cited by 19 publications

(15 citation statements)

References 27 publications

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“…As a consequence, the total quantity of thin fibers may increase, leading to carcinogenic effects. 68,[93][94][95][96][97][98][99][100] The carcinogenic effect of fibers depends on dose, dimension, and durability, commonly known as the three "D's". 19,[101][102][103] If the biopersistence of carcinogenic is equal, differences in toxicity depend on the fiber dimensions.…”

Section: Serpentine and Amphibole Asbestosmentioning

confidence: 99%

Asbestos-related Cancer: Exaggerated Risk Perception

Jargin¹

2023

Cancer Screen Prev

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Health risks from exposure to asbestos fibers have been evaluated based on professional histories, when fiber concentrations at workplaces were greater than today. A linear no-threshold model was used for risk estimation, although its relevance has not been proven. Asbestos fibers are often detected in lungs and pleura during autopsy, but finding evidence of fibers does not prove that a disease has been caused by asbestos. Thus, targeted detection of mesothelioma and other conditions associated with asbestos exposures has resulted in an increase in the reported incidence of mesothelioma among high-risk groups. Histological and immunochemical characteristics of malignant mesothelioma partially overlap with other cancers, which may also contribute to the overdiagnosis in exposed populations. Differences in carcinogenicity of various asbestos types are discussed here. Prohibitions of asbestos in some developed countries must be reconsidered on the basis of independent research. Lifelong bioassays are the most promising way to obtain reliable information regarding asbestos-related malignancy. It should be stressed that non-use of asbestos contributes to an increase of harm from fires, armed conflicts, and traffic accidents.

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Section: Serpentine and Amphibole Asbestosmentioning

confidence: 99%

Asbestos-related Cancer: Exaggerated Risk Perception

Jargin¹

2023

Cancer Screen Prev

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“…As a result, the total number of fibrils increases [40][41][42][43][44][45], possibly with carcinogenicity. Presumably, the thinner the fiber, the greater its capacity to cause cancer because it can penetrate tissues more efficiently [46]. Chrysotile was the predominant asbestos fiber found in the pleura, particularly in pleural plaques [38,[47][48][49].…”

Section: Chrysotile Vs Amphibolesmentioning

confidence: 99%

Asbestos-related Lung Diseases: A Brief Update

Jargin

2022

J Inflamm Dis

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Health risks from asbestos exposures have been evaluated, considering past professional histories when exposures at workplaces were higher than today. A linear no-threshold (LNT) model has been applied, although its relevance is unproven. Fibers are often found in the lungs and pleura of deceased people. Fiber findings do not prove that a disease is caused by asbestos. It is reasonable to assume that a targeted search for mesothelioma and other asbestos-related conditions in asbestos workers resulted in an increased detection rate. Histological and immunohistochemical characteristics of malignant mesothelioma partly overlap with other cancers, which may contribute to the overdiagnosis in exposed populations. The etiology and differential diagnosis of malignant pleural mesothelioma as well as differences in carcinogenicity between different asbestos types are briefly discussed here. In the author’s opinion, current regulations applied in some countries are excessive and should be reconsidered based on independent research. The most promising way to obtain reliable information would be through lifelong bioassays. It can be reasonably assumed that the non-use of asbestos-containing brakes, fireproofing, insulation, etc. increases the harm caused by fires, traffic accidents, and armed conflicts.

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“…It can result in asbestos-related diseases such as lung cancer, mesothelioma, or asbestosis (Park, 2018). Several factors are listed as an asbestos concentration in the ambient air, the exposure time, size and type of the fibers, functional and anatomical conditions of exposed employers, and the respiratory rate associated with physical exertion for the health hazard of asbestos (Rodilla et al, 2021). The previous studies figure out the most significant risk exists with exposure to amphibole fibers, followed by mixed fibers (amphibole and chrysotile), and finally, chrysotile (Rodilla et al, 2021).…”

Section: Asbestos Effects On Human Healthmentioning

confidence: 99%

“…Several factors are listed as an asbestos concentration in the ambient air, the exposure time, size and type of the fibers, functional and anatomical conditions of exposed employers, and the respiratory rate associated with physical exertion for the health hazard of asbestos (Rodilla et al, 2021). The previous studies figure out the most significant risk exists with exposure to amphibole fibers, followed by mixed fibers (amphibole and chrysotile), and finally, chrysotile (Rodilla et al, 2021). In addition, the risk of asbestos in the air bases on the type of asbestos, the physicochemical characteristics of these fibers, the intensity of exposure and, for some pathologies, co-exposures with other carcinogens (Rodilla et al, 2021).…”

Section: Asbestos Effects On Human Healthmentioning

confidence: 99%

“…The previous studies figure out the most significant risk exists with exposure to amphibole fibers, followed by mixed fibers (amphibole and chrysotile), and finally, chrysotile (Rodilla et al, 2021). In addition, the risk of asbestos in the air bases on the type of asbestos, the physicochemical characteristics of these fibers, the intensity of exposure and, for some pathologies, co-exposures with other carcinogens (Rodilla et al, 2021). Therefore, these factors should be considered while measuring the asbestos health effects.…”

Section: Asbestos Effects On Human Healthmentioning

confidence: 99%

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Characterization of Asbestos in Ambient Air During Refractory Material Production from Magnesite Ore

Küçüker

2021

Journal of Advanced Research in Natural and Applied Sciences

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Asbestos is a general term employed for crystallized silicate minerals in fibril form. It can be commonly found in nature and from which fibre uses in the industry through processing are obtained. However, there is limited information about the air quality in terms of asbestos for the companies that produce refractory materials from magnesite ore. This deficiency in the literature can be eliminated with this study for a company with high quality and durable refractory materials. Among the most used asbestos analysis are scanning electron microscope (SEM), transmission electron microscope (TEM). Asbestos analyses have been performed in two different institutions on the parallel samples whose preliminary processes have been completed. According to the SEM results, 23 of the observed fibrils in a total area are bigger than 5 µmin lengths and less than 3 µm in width. Three of fibrils were observed to have the characteristics of chrysotile fibres morphemically and elementally. In addition, airborne samples were analyzed using a TEM instrument. According to the results obtained, 13 of the observed fibrils in total were bigger than 5 µm in length and less than 3 µm in width and based on Electron Diffraction analysis and elemental composition (EDXA) results of these fibrils, and they were not observed to have the characteristics of chrysotile fibres. Most of the observed fibrils were noted to be other inorganic minerals (lizardite) fibrils. Additionally, the obtained results show that the asbestos concentration in the air is below the limit specified by the provision (0.1 fiber/cm 3 ).

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Fiber burden and asbestos-related diseases: an umbrella review

Cited by 19 publications

References 27 publications

Asbestos-related Cancer: Exaggerated Risk Perception

Asbestos-related Cancer: Exaggerated Risk Perception

Asbestos-related Lung Diseases: A Brief Update

Characterization of Asbestos in Ambient Air During Refractory Material Production from Magnesite Ore

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