Fiber-based tissue engineering: Progress, challenges, and opportunities

Tamayol, Ali; Akbari, Mohsen; Annabi, Nasim; Paul, Arghya; Khademhosseini, Ali; Juncker, David

doi:10.1016/j.biotechadv.2012.11.007

Cited by 393 publications

(376 citation statements)

References 161 publications

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“…There are several different methods of producing fiber-based scaffolds, such as electrospinning, meltspinning, wetspinning, biospinning and microfluidic spinning 5,6 . The wetspinning method was chosen for this study.…”

Section: Introductionmentioning

confidence: 99%

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

et al. 2017

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The main aim of this study was to develop scaffolds based on alginate, chitosan and hybrid fibers with and without glycerol. The scaffolds developed underwent assessments for tensile property, swelling ratio and weight loss, cellular viability, degradation and biomineralization, as well as DSC/TGA thermal analysis. Tenacity values showed that use of glycerol and the interaction between alginate and chitosan as a hybrid fiber were associated with increasing tenacity values. In the swelling and weight loss study, the scaffolds containing glycerol presented lower weight loss and higher water absorption values in all scaffolds, compared to scaffolds without glycerol, indicating that glycerol acted as a stabilizer. None of the alginate, chitosan and hybrid scaffolds, with or without glycerol, decreased cell viability. On the third day of the biomineralization assay, chitosan without glycerol indicated the presence of apatite crystals. The degradation study showed that glycerol may have acted as a stabilizer.

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Section: Introductionmentioning

confidence: 99%

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

et al. 2017

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“…They can be fabricated in large scales using well‐known and simple techniques, such as weaving, knitting, and embroidering. Another key advantage of using textiles is that the mechanical properties of individual strands and the entire fabric can be tuned by changing the properties of the fibers or the architecture of the fabric during the manufacturing process 314. To this end, a flexible and fiber‐based pH sensor was recently fabricated by loading pH‐sensitive microspheres into alginate‐based microfibers 23.…”

Section: Healthcare Monitors For Empowering the Patientmentioning

confidence: 99%

Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future

et al. 2018

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At the crossroads of chemistry, electronics, mechanical engineering, polymer science, biology, tissue engineering, computer science, and materials science, electrical devices are currently being engineered that blend directly within organs and tissues. These sophisticated devices are mediators, recorders, and stimulators of electricity with the capacity to monitor important electrophysiological events, replace disabled body parts, or even stimulate tissues to overcome their current limitations. They are therefore capable of leading humanity forward into the age of cyborgs, a time in which human biology can be hacked at will to yield beings with abilities beyond their natural capabilities. The resulting advances have been made possible by the emergence of conformal and soft electronic materials that can readily integrate with the curvilinear, dynamic, delicate, and flexible human body. This article discusses the recent rapid pace of development in the field of cybernetics with special emphasis on the important role that flexible and electrically active materials have played therein.

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“…Electrospinning enables control of ber diameter, sca old density, orientation, and material biochemistry, allowing for the creation of biomimetic matrices. Fiber-based TE is a whole sub-eld of methods and applications (reviewed in: (Tamayol et al, 2013)). We have used electrospun PCL sca olds for cartilage constructs and skin constructs (unpublished, manuscript pending) in both random and aligned orientations.…”

Section: Extracellular Matrices: Sca Olds For Cells and Tissuementioning

confidence: 99%

Fibroblast Differentiation and Models of Human Skin

Rakar¹

2016

Linköping University Medical Dissertations

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Denna bok avhandlar en riktning av biomedicinsk forskning som i det långa loppet sy ar till att nå bättre och banbrytande sätt att läka våra kroppar. Forskningen vilar på en tredelad grund -viktiga kunskaper som leder mot en generell förståelse för hur celler blir till vävnader, hur vävnad-er och organ kan manipuleras på ett kliniskt användbart sätt, och till sist hur denna kunskap kan appliceras på människans hudorgan.Den första delen handlar om cellers identitet, och den stora potentialen som våra egna stamceller har för framtidens läkekonst. Genom att förstå hur celler egentligen fungerar på arvsmassenivå kan vi utöka arsenalen av verktyg vi har för att få celler att bete sig på de sätt som behövs för att skapa nya organ. Vi har jobbat med att karakterisera och manipulera broblaster, en av de vanligaste celltyperna i människokroppen, och bland annat tagit fram olika typer av fettceller.Den andra delen handlar om hur man använder celler, biokemiska faktorer och biokompatibla material för att konstruera vävnader och organ. Innan forskningen når klinisk användbarhet har vi möjlighet att bygga begränsade modellsystem för att studera människans biologi. Cellsystem på labbet är mycket viktiga verktyg för att föra forskningen på vävnadsbyg-gande framåt.Den tredje delen behandlar hudforskning speci kt, och här samlas kunskaper från tidigare delarna som är relevanta för mänsklig hud. Här beskrivs användningen av två olika hudmodeller för att undersöka proceser viktiga vid sårläkning. Vidare beskrivs planerna kring ett större påbörjat projekt som sy ar till att använda alla tidigare lärdomar och tekniker för att åstadkomma en ny terapi för sårläkning.Abstract is thesis combines three publications and one manuscript, covering two principal topics: functional di erentiation of human broblasts and, laboratory models of human skin. e two topics favourably unite in the realm of tissue engineering. is thesis is therefore split into three main parts: 1. a discussion of phenotypic plasticity as it pertains to broblasts and the stem cell continuum; 2. a short review of engineered tissue, with particular focus on soluble factors and materials; and, 3. a motivated review of the biology, diversity and culture of skin, including skin construction. e intended goal of our research endeavor was to achieve the formulation of a bioactive therapy for skin regeneration. e main hypothesis was that broblast-to-keratinocyte di erentiation would facilitate wound healing, and that the protocol for such a method could be adapted to clinical translation. e foundation for the hypothesis lay in the di erentiation capabilities of primary dermal broblasts (Paper I). However, the goal has not yet been achieved. Instead, intermediate work on the construction of skin for the purpose of creating a model test-bed has resulted in two other publications. e use of excised human skin, a formidable reference sample for tissue engineered skin, has been used to investigate a gelatin-based material in re-epithelialization (Paper II). A rst attempt at standardizi...

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Fiber-based tissue engineering: Progress, challenges, and opportunities

Cited by 393 publications

References 161 publications

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future

Fibroblast Differentiation and Models of Human Skin

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