This chapter discusses interference excision techniques in spread spectrum communications systems. Both stationary and nonstationary interferers are considered. Sinusoidal, autoregressive, digital communication, and polynomial phase interference signals are effectively suppressed by different excision methods; each is suitable for one or more types of interferers. Time‐, frequency‐, and time‐frequency domain methods for analysis and estimation of the interference parameters are summarized. Domains other than time and frequency, such as the Gabor‐domain, the Wavelet‐domain, and quadratic time‐frequency signal representations, are appropriate for nontraditional smart jamming in which the interference parameters are highly dependent on time. Excision methods can be linear, bilinear, or nonlinear with performance dependent on the interference power relative to the desired signal and noise. In some cases, the slight performance enhancement offered by bilinear and nonlinear methods may not properly justify the increase in the algorithm complexity. The BER and receiver SINR expressions and curves are presented in this chapter for some of the key interference excision techniques.