FGR Src Family Kinase Causes Signaling and Phenotypic Shift Mimicking Retinoic Acid-Induced Differentiation of Leukemic Cells
Noor Kazim,
Wang Peng,
Jianbo Yue
et al.
Abstract:Retinoic acid (RA) is an embryonic morphogen used in cancer differentiation-therapy. It causes a plethora of changes in gene expression culminating in cell differentiation. We now find that amongst them, expression of the Src-family-kinase, FGR, by itself causes cell differentiation analogous to RA. The historically dominant/classical paradigm for RA mechanism of action is transcriptional activation via binding to the ligand-activated nuclear receptors, RAR/RXR. In the HL-60 human myelo-monocytic leukemia mode… Show more
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