FGR in the setting of preterm sterile intra‐uterine milieu is associated with a decrease in RDS

Park, Chan-Wook; Park, Joong Shin; Jun, Jong Kwan; Yoon, Bo Hyun

doi:10.1002/ppul.23369

Cited by 3 publications

(2 citation statements)

References 59 publications

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“…This likely depends on the etiology of the fetal growth restriction (FGR). Park et al examined the relationship between FGR in the absence of infection and inflammation with the risk to develop RDS, providing some mechanistic clues. Since there is an association of chorioamnionitis and post‐natal infection with the risk for developing BPD, they excluded cases with inflammation/infection.…”

Section: Neonatologymentioning

confidence: 99%

Pediatric pulmonology year in review 2016: Part 2

et al. 2017

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Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection.Word count: 71 3

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Section: Neonatologymentioning

confidence: 99%

Pediatric pulmonology year in review 2016: Part 2

et al. 2017

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“…Immaturity of the lungs at birth can lead to respiratory distress syndrome (RDS), a main cause of neonatal mortality and morbidity [39]. Interestingly, many studies show that intrauterine inflammation has a positive impact on RDS, diminishing its incidence by accelerating lung maturation and surfactant production [40][41][42]. However, chorioamnionitis induces fetal lung inflammation [43] and increases the risk of bronchopulmonary dysplasia, an alveolar and vascular malformation and dysfunction [41].…”

Section: Inflammation In Preterm Birthmentioning

confidence: 99%

Preterm Birth: An Inflammatory Syndrome, Not Just A Myometrial Disorder

Mai-Vo¹,

Nadeau-Vallée²,

Beaudry-Richard³

2017

UOJM

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Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. Although the severity of neonatal outcomes is inversely correlated with gestational age, all PTBs can lead to potentially life-threatening neonatal outcomes and major lifelong health complications. Because advances in neonatal care have substantially decreased neonatal mortality, the incidence of PTB and its complications is unabatedly rising. PTB currently affects more than 10% of births worldwide, with similar numbers in developed countries. Correspondingly, improving neonatal outcome is a key objective of the World Health Organization. The recently approved (in Europe) tocolytics drug, Atosiban, used to prolong preterm gestation, has not been shown to improve neonatal outcome, nor have other tocolytic agents used in clinic. Thus, PTB remains an unmet medical need. Recent evidence shows that most, if not all, PTBs are associated with (overt or occult) inflammatory processes in gestational tissues, independent of infection. Proinflammatory cytokines are produced from maternal and fetal cells in response to sterile or infectious stressors. These seem to orchestrate a multi-tissue response including myometrial contractility, cervical ripening, and weakening/rupture of fetal membranes, leading to the onset of preterm labor. This integrated system might have been conserved through mammalian evolution due to increased maternal and/or fetal survival when gestation is terminated in specific settings, such as infection. Hence, inflammation may be a common pathway to the numerous aetiologies of PTB. Most importantly, recent evidence suggests that inflammation is transmitted to the fetus, thereby inducing organ injuries that may underlie the development of major neonatal diseases. Targeting inflammation prenatally instead of myometrial contraction could be a more successful and safe approach for the management of PTB, as suggested by recent animal studies. ABSTRACTLa naissance prématurée est la principale cause de mortalité et de morbidité néonatale. Bien que la sévérité des issus néonataux soit inversement corrélée avec l'âge gestationnel à la naissance, toutes les naissances prématurées peuvent mener à des issus néonataux potentiellement mortels et à des complications avec répercussions s'échelonnant sur toute la vie. Étant donné que la mortalité néonatale a considérablement diminuée avec les récentes avancées en néonatalogie, l'incidence de la naissance préma-turée et de ses complications sont en hausse. La naissance prématurée affecte présentement plus de 10% des naissances à travers le monde, avec des taux similaires dans les pays développés. Conséquemment, d'améliorer l'issu néonatal est un objectif clé de l'Organisation Mondiale de la Santé. Le tocolytique Atosiban récemment approuvé (en Europe) pour prolonger les gestations pré-maturées n'a pas démontré d'efficacité pour améliorer les issus néonataux, tout comme les autres tocolytiques utilisés en clinique, et la naissance prématurée demeure un besoin médical non-atteint. Des données r...

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Perinatal Outcomes of Small for Gestational Age Infants in a Korean Tertiary Medical Center

Ko¹,

Kim²,

Park³

et al. 2018

journalofthekoreansocietyofmaternalandchildhealth

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Purpose: To examine the perinatal outcomes of small for gestational age (SGA) infants, compared with non-SGA infants and those born at 39 weeks, and to determine the optimal gestational age of delivery Methods: We performed a retrospective cohort study (n=7,580) for births at a tertiary hospital. SGA was stratified into severe (below 5th percentile) and moderate (5~10th percentile) groups. Statistical comparison was performed using the χ 2 test and multivariable logistic regression models. Results: As compared to the non-SGA group at 38 weeks births, the odds of sepsis were significantly increased ' in the moderate SGA group (OR 2.84, 95% CI, 1.12~7.20) and severe SGA group (OR 3.63, 95% CI, 1.14~11.58). In addition, the odds of respiratory distress syndrome at 41 weeks births were significantly increased in mo ' derate SGA (OR 15.32, 95% CI, 1.92~122.08) and severe SGA (OR 16.31, 95% CI, 1.18~226.14) groups, compared to it in the non-SGA group. The odds of other neonatal outcomes in the moderate SGA group were not significantly increased, as compared to the non-SGA group. However, the odds of neonatal intensive care unit admission and composite morbidity in the severe SGA group were significantly increased at 35, 36, 38, 39, 40, and 41 weeks births, as compared to the non-SGA group. There was no significant difference in neonatal out ' comes from 38 to 41 weeks in moderate SGA, and from 37 to 41 weeks in severe SGA. Conclusion: If there is no medical indication, delivery at 39 weeks can be considered in SGA pregnancies. However, delivery can be planned from 37 gestational weeks in severe SGA pregnancies,with a subjective finding of fetal compromise.

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FGR in the setting of preterm sterile intra‐uterine milieu is associated with a decrease in RDS

Cited by 3 publications

References 59 publications

Pediatric pulmonology year in review 2016: Part 2

Pediatric pulmonology year in review 2016: Part 2

Preterm Birth: An Inflammatory Syndrome, Not Just A Myometrial Disorder

Perinatal Outcomes of Small for Gestational Age Infants in a Korean Tertiary Medical Center

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