FGF23-regulated production of Fetuin-A (AHSG) in osteocytes

Mattinzoli, Deborah; Rastaldi, Maria Pia; Ikehata, Masami; Armelloni, Silvia; Pignatari, C.; Giardino, Laura; Li, M.; Alfieri, Carlo; Regalia, Anna; Riccardi, Daniela

doi:10.1016/j.bone.2015.10.008

Cited by 29 publications

(32 citation statements)

References 40 publications

(51 reference statements)

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“…31 These genes encode for fibroblast growth factor 23 (FGF23), the members of short integrin-binding ligand-interacting glycoprotein (SIBLING) family of proteins DMP1 and matrix extracellular phosphoglycoprotein (MEPE), phosphate-regulating gene with homologies to endopeptidases on the X-chromosome (Phex), and fetuin-A (Figure 2 and 3). 31, 49 …”

Section: Molecular and Functional Signature Of Osteocytesmentioning

confidence: 99%

“…49 Fetuin-A might be involved in the formation of cellular processes by slowing calcification of the matrix that surrounds developing osteocytes.…”

Section: Molecular and Functional Signature Of Osteocytesmentioning

confidence: 99%

“…Some examples of this interplay are the high levels of FGF23 exhibited in humans in the absence of DMP1 and Phex function, 53 the decrease in active FGF23 levels due to Phex binding to DMP1, the reversal of the hypophosphatemia of Phex-deficient mice by FGF23 deletion, 51 and the increase in fetuin-A expression in osteocytes by an autocrine function of FGF23. 49 Altered expression of some of the osteocytic genes described above causes disorders of phosphate homeostasis in humans. 53 Excess production of FGF23 or gain-of-function mutations of this hormone results in hypophosphatemia, renal phosphate wasting, low vitamin D3 levels and vitamin D-resistant rickets, a condition known as autosomal dominant hypophosphatemic rickets (ADHR).…”

Section: Molecular and Functional Signature Of Osteocytesmentioning

confidence: 99%

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Osteocytic signalling pathways as therapeutic targets for bone fragility

2016

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Osteocytes are differentiated osteoblasts that become surrounded by matrix during the process of bone formation. The acquisition of the osteocyte phenotype is achieved by profound modifications in gene expression that confer adaptation to the changing cellular functions and constitute the molecular signature of osteocytes. The levels of expression of genes characteristic of osteoblasts is altered; and the expression of genes/proteins that impart dendritic cellular morphology, regulate matrix mineralization, and control the function of bone surface cells, is orderly modulated during osteocytogenesis. The discovery of human mutations of osteocytic genes had contributed to a large extent to reveal the role of osteocytes in bone homeostasis. Osteocytes are targets of mechanical force imposed to the skeleton and also play a critical role in integrating mechanosensory pathways with the action of hormones, thereby leading to the orchestrated response of bone to environmental cues. Current, novel therapeutic approaches harness this accumulating knowledge by targeting osteocytic signaling pathways and messengers to improve skeletal health.

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Section: Molecular and Functional Signature Of Osteocytesmentioning

confidence: 99%

“…49 Fetuin-A might be involved in the formation of cellular processes by slowing calcification of the matrix that surrounds developing osteocytes.…”

Section: Molecular and Functional Signature Of Osteocytesmentioning

confidence: 99%

Section: Molecular and Functional Signature Of Osteocytesmentioning

confidence: 99%

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Osteocytic signalling pathways as therapeutic targets for bone fragility

2016

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“…There were no emPAI scores that significantly and positively correlated with age. AHSG, also known as fetuin-A, is produced not only in the liver but also in osteocytes [47], and is characterized by particularly high mineral affinity. IGFBP5 is an IGF-binding protein involved in the regulation of cell growth and is the most abundant IGFBP stored in bone, where it controls osteoblast differentiation and osteoblast–osteoclast crosstalk [48].…”

Section: Resultsmentioning

confidence: 99%

Proteomic profiling of archaeological human bone

et al. 2017

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Ancient protein analysis provides clues to human life and diseases from ancient times. Here, we performed shotgun proteomics of human archeological bones for the first time, using rib bones from the Hitotsubashi site (AD 1657–1683) in Tokyo, called Edo in ancient times. The output data obtained were analysed using Gene Ontology and label-free quantification. We detected leucocyte-derived proteins, possibly originating from the bone marrow of the rib. Particularly prevalent and relatively high expression of eosinophil peroxidase suggests the influence of infectious diseases. This scenario is plausible, considering the overcrowding and unhygienic living conditions of the Edo city described in the historical literature. We also observed age-dependent differences in proteome profiles, particularly for proteins involved in developmental processes. Among them, alpha-2-HS-glycoprotein demonstrated a strong negative correlation with age. These results suggest that analysis of ancient proteins could provide a useful indicator of stress, disease, starvation, obesity and other kinds of physiological and pathological information.

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“…In a prospective cohort of 3860 patients with CKD stages 2-4, enhanced FGF-23 levels were associated with higher risk of CVD, especially with CHF [72]. FGF-23 seems to regulate the production of fetuin-A, a glycoprotein with anti-calcification activity [73]. Considering the crosstalk between these two proteins, both appear as promising renocardiovascular biomarkers.…”

Section: Other Markersmentioning

confidence: 99%

Cardiovascular Risk Factors in End-Stage Renal Disease Patients: The Impact of Conventional Dialysis versus Online-Hemodiafiltration

Coimbra¹,

Faria²,

Miranda³

et al. 2018

Aspects in Dialysis

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End-stage renal disease (ESRD) patients present high incidence of cardiovascular (CV) events, which are the most common causes of death in these patients. The occurrence of CV events appears as a consequence of the high prevalence of traditional and nontraditional CV risk factors. Online-hemodiafiltration (OL-HDF) was introduced as a better alternative to conventional dialysis, as it was proposed to be more biocompatible, to increase dialysis efficacy, to reduce the inflammatory response to treatment and to improve patient's quality of life, contributing to reduce CV and all-cause mortality risk in ESRD. However, data in literature, comparing the effect of OL-HDF with conventional dialysis for clinical CV outcome and all-cause mortality, yielded controversy about those benefits of OL-HFD over standard hemodialysis. A review of the traditional CV risk factors (e.g., arterial hypertension, diabetes mellitus, dyslipidemia, obesity, smoking and advanced age), non-traditional risk factors (e.g., anemia, oxidative stress, hyperphosphatemia, endothelial dysfunction, left ventricular hypertrophy, insulin resistance, high levels of lipoprotein(a) and inflammation) and potential renocardiovascular biomarkers, in the setting of ESRD, is presented. The impact of conventional hemodialysis and OL-HDF on CV risk factors and on the outcome of ESRD patients is also addressed.

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FGF23-regulated production of Fetuin-A (AHSG) in osteocytes

Cited by 29 publications

References 40 publications

Osteocytic signalling pathways as therapeutic targets for bone fragility

Osteocytic signalling pathways as therapeutic targets for bone fragility

Proteomic profiling of archaeological human bone

Cardiovascular Risk Factors in End-Stage Renal Disease Patients: The Impact of Conventional Dialysis versus Online-Hemodiafiltration

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