FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis

Zhu, Junjie; Jin, Zhouxiang; Wang, Jie; Wu, Zhaohang; Xu, Tianpeng; Tong, Gaozan; Shen, Enzhao; Fan, Junfu; Jiang, Chunhui; Wang, Jiaqi; Li, Xiaokun; Cong, Weitao; Lin, Li

doi:10.1016/j.jare.2024.04.004

Journal of Advanced Research

2024

DOI: 10.1016/j.jare.2024.04.004

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FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis

Junjie Zhu,

Zhouxiang Jin,

Jie Wang

et al.

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Serum FGF-21 Levels During COVID-19 Infection Recovery Period

Demir,

Cetin,

Milletli Sezgin

2024

Haseki

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Abs tractAim: Mitochondrial dysfunction causes oxidative stress, which triggers the release of proinflammatory cytokines, which play an important role in the immune response. One of these cytokines, fibroblast growth factor-21 (FGF-21), has demonstrated an increase in its level in severe coronavirus disease-2019 (COVID-19) infection. In this context, this study aimed to investigate whether FGF-21 can be used in the follow-up of COVID-19 infection.Methods: This study was conducted as a cross-sectional design between January 1, 2022, and December 31, 2022. This study included women and men over 18 years old who had recovered from the COVID-19 infection (n=27). The data regarding hospitalization place (internal medicine ward, internal medicine ward + intensive care unit), comorbidities, vital signs, acute respiratory distress syndrome development, and applied treatments were obtained from hospital records. Fibroblast growth factor-21 levels were specifically studied for this study. Results:The FGF-21 level was found to be 254 pg/mL at the beginning of the study and increased to 454 pg/mL at the end of the study. The difference was found to be statistically significant (p=0.004). Conclusion:Considering the increasing level of FGF-21 compared to the beginning of the infection, it is thought that FGF-21 plays a role in the healing process in the COVID-19 infection.

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Serum FGF-21 Levels During COVID-19 Infection Recovery Period

Demir,

Cetin,

Milletli Sezgin

2024

Haseki

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FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis

Cited by 1 publication

References 72 publications

Serum FGF-21 Levels During COVID-19 Infection Recovery Period

Serum FGF-21 Levels During COVID-19 Infection Recovery Period

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