Fgf18 is required for embryonic lung alveolar development

Usui, Hachiro; Shibayama, M.; Ohbayashi, Norihiko; Konishi, Morichika; Takada, Shinji; Itoh, Nobuyuki

doi:10.1016/j.bbrc.2004.07.198

Cited by 78 publications

(67 citation statements)

References 17 publications

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“…Messenger RNA encoding FGF18 is also detected in theca cells (Portela et al 2010) although expression of FGFR2c and FGFR3c is detectable in both granulosa and theca cells (Berisha et al 2004, Buratini et al 2005. This is not inconsistent with the developmental change of expression of FGFR2c in the embryonic mouse, for which mRNA is detected only in the epithelium of very early lung and limb buds (Oldridge et al 1999, Usui et al 2004) and becomes detectable also in the mesenchyme after embryonic day 15 (Usui et al 2004). Whether a similar shift in the pattern of expression of FGFR2c and FGFR3c occurs during development of the ovary or development of preantral follicles is not known.…”

Section: Fgfs and Mesenchymal-epithelial Cell Signalingmentioning

confidence: 68%

“…In the developing limb, FGF10 secreted from the mesenchyme activates FGFR2b in the apical ectodermal ridge, which is a critical early step in formation of the limb bud. In the developing mouse lung, mesenchymal FGF10 activation of epithelial FGFR2b is essential for airway branching (Colvin et al 2001), and mesenchymal FGF18 is essential for alveolar development, acting through epithelial FGFR2c (Usui et al 2004). The pivotal early role of FGF10 signaling was demonstrated in FGFR2b knockout mice, which die at birth with severe defects of the limbs and lungs as well as salivary glands and other tissues (De Moerlooze et al 2000).…”

Section: Fgfs and Mesenchymal-epithelial Cell Signalingmentioning

confidence: 99%

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Mechanisms of fibroblast growth factor signaling in the ovarian follicle

Price

2015

Journal of Endocrinology

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Fibroblast growth factors (FGFs) have been shown to alter growth and differentiation of reproductive tissues in a variety of species. Within the female reproductive tract, the effects of FGFs have been focused on the ovary, and the most studied one is FGF2, which stimulates granulosa cell proliferation and decreases differentiation (decreased steroidogenesis). Other FGFs have also been implicated in ovarian function, and this review summarizes the effects of members of two subfamilies on ovarian function; the FGF7 subfamily that also contains FGF10, and the FGF8 subfamily that also contains FGF18. There are data to suggest that FGF8 and FGF18 have distinct actions on granulosa cells, despite their apparent similar receptor binding properties. Studies of non-reproductive developmental biology also indicate that FGF8 is distinct from FGF18, and that FGF7 is also distinct from FGF10 despite similar receptor binding properties. In this review, the potential mechanisms of differential action of FGF7/FGF10 and FGF8/FGF18 during organogenesis will be reviewed and placed in the context of follicle development. A model is proposed in which FGF8 and FGF18 differentially activate receptors depending on the properties of the extracellular matrix in the follicle.

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Section: Fgfs and Mesenchymal-epithelial Cell Signalingmentioning

confidence: 68%

Section: Fgfs and Mesenchymal-epithelial Cell Signalingmentioning

confidence: 99%

Mechanisms of fibroblast growth factor signaling in the ovarian follicle

Price

2015

Journal of Endocrinology

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“…Fgf10 is critical for epithelial-mesenchymal interactions necessary for the development of epithelial components of multiple organs (Min et al, 1998;Sekine et al, 1999;Ohuchi et al, 2000;Sakaue et al, 2002). Fgf9 and Fgf18 have essential roles in the development of mesenchymal components of multiple organs (Colvin et al, 2001a, 2001b, Ohbayashi et al, 2002Liu et al, 2002;Usui et al, 2004). In contrast, Fgf15 knockout mice die at variable times during embryonic and postnatal stages of development.…”

Section: Phenotypes Of Fgf Knockout Micementioning

confidence: 99%

Functional evolutionary history of the mouse Fgf gene family

Itoh

Ornitz

2007

Developmental Dynamics

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313

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“…[6][7][8] Given the contrasting results on lung cancer progression and survival and the FGFR4 Gly388Arg polymorphism, we investigated the association of this and other polymorphisms in known FGFR4 ligands in a large cohort of lung adenocarcinoma (ADCA) patients with updated follow-up. Among several FGFs that bind FGFR4, namely FGF1, 2, 4, 6, 8, 9, 16, 17, 18 and 19, 9 we selected FGF9, based on its regulatory role in lung differentiation, 10 FGF18, because it plays a role in lung alveolar development, 11 and FGF19, because it binds specifically only FGFR4. 12 To test for a possible functional role of the FGFR4 Gly388Arg polymorphism, we examined the gene expression profile of normal lung in association with FGFR4 allele status.…”

Section: Uiccmentioning

confidence: 99%

FGFR4 Gly388Arg polymorphism may affect the clinical stage of patients with lung cancer by modulating the transcriptional profile of normal lung

Falvella

Frullanti

Galvan

et al. 2009

Intl Journal of Cancer

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The association of the fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism with clinical stage and overall survival in a series of 541 Italian lung adenocarcinoma (ADCA) patients indicated a significantly decreased survival in patients carrying the rare Arg388 allele as compared to that in Gly/Gly homozygous patients [hazard ratio (HR) 5 1.5; 95% confidence interval (CI) 1.1-1.9], with the decrease related to the association of the same polymorphism with clinical stage (HR 5 1.8, 95% CI 1.3-2.6). By contrast, no significant association was detected in small series of either Norwegian lung ADCA patients or Italian lung squamous cell carcinoma (SQCC) patients. Single nucleotide polymorphisms of known FGFR4 ligands expressed in lung (FGF9, FGF18 and FGF19) were not associated with clinical stage or survival and showed no interaction with FGFR4. Analysis of gene expression profile in normal lungs according to FGFR4 genotype indicated a specific transcript pattern associated with the allele carrier status, suggesting a functional role for the FGFR4 polymorphism already detectable in normal lung. These findings confirm the significant association of the FGFR4 Gly388Arg polymorphism with clinical stage and overall survival in an Italian lung ADCA population and demonstrate a FGFR4 genotype-dependent transcriptional profile present in normal lung tissue. ' 2009 UICC

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Fgf18 is required for embryonic lung alveolar development

Cited by 78 publications

References 17 publications

Mechanisms of fibroblast growth factor signaling in the ovarian follicle

Mechanisms of fibroblast growth factor signaling in the ovarian follicle

Functional evolutionary history of the mouse Fgf gene family

FGFR4 Gly388Arg polymorphism may affect the clinical stage of patients with lung cancer by modulating the transcriptional profile of normal lung

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