FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth

Iongh, Robb U. de; Lovicu, Frank J.; Hanneken, Anne; Baird, Andrew; McAvoy, John W.

doi:10.1002/(sici)1097-0177(199608)206:4<412::aid-aja7>3.0.co;2-l

Cited by 46 publications

(22 citation statements)

References 41 publications

(28 reference statements)

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“…Analogously, several members of the FGF receptor family are expressed in the lens lineage (de Iongh et al, 1996(de Iongh et al, , 1997, and delayed fiber differentiation has been documented in Tfr7-transgenic mice expressing dominant-negative FGF receptors (Chow and Lang, 2001). Taken together, these results clearly show the importance of FGF8 at different stages of lens fiber differentiation, but the distinct functions of FGF signaling in proliferation and differentiation during lens development remain to be determined.…”

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confidence: 74%

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Lens differentiation and crystallin regulation: a chick model

Reza¹,

Yasuda²

2004

Int. J. Dev. Biol.

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The vertebrate lens is a transparent polarized tissue that acts as the gateway for vision. The chick lens is an excellent model for studying tissue organogenesis, since it is both accessible and easily manipulated during embryonic stages. The chick lens consists of two morphologically discrete compartments, the epithelium and the fiber-cell mass. Evidence indicates that the early phases of lens development involve several sequential events, including tissue interactions, cell proliferation and differentiation. The morphological change during lens development is associated with the concurrent and distinct functions of numerous transcription factors. Diffusible molecules from the complementary neural tissue play vital roles during the entire process of lens development. Lens tissue is characterized by the ample production of crystallins, lens specific proteins which provide structural integrity and functional properties to the lens. Thus, the study of crystallin regulation should provide insight into the development of a functional lens during embryogenesis. This process has been shown to involve a complex and evolutionary conserved pathway supported by different regulatory proteins.

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confidence: 74%

“…FGF receptors are similarly expressed in the lens lineage (de Iongh et al, 1996(de Iongh et al, , 1997. Tfr7 transgenic mice expressing dominant-negative FGF receptors coupled to the lens enhancer/promoter PO, which is driven only by ectodermal Pax6, show poorly developed lens placode (Faber et al, 2001).…”

Section: Role Of Optic Vesicle In Placode Formationmentioning

confidence: 99%

Lens differentiation and crystallin regulation: a chick model

Reza¹,

Yasuda²

2004

Int. J. Dev. Biol.

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“…Disturbing normal patterns of FGF distribution by lens-specific over-expression of FGFs led to ectopic fibre differentiation in the epithelial compartment [13,14]. The mammalian lens expresses at least three of the four FGF receptor (FGFR) genes [15,16]. A series of experiments that deleted combinations of these FGFRs showed that there is considerable redundancy among FGFRs but that loss of all receptors resulted in failure of fibre differentiation such that the embryonic lens remains at the vesicle stage [4,17,18].…”

Section: Lens Fibre Differentiationmentioning

confidence: 99%

Understanding the role of growth factors in embryonic development: insights from the lens

Lovicu

McAvoy

Iongh

2011

Phil. Trans. R. Soc. B

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Growth factors play key roles in influencing cell fate and behaviour during development. The epithelial cells and fibre cells that arise from the lens vesicle during lens morphogenesis are bathed by aqueous and vitreous, respectively. Vitreous has been shown to generate a high level of fibroblast growth factor (FGF) signalling that is required for secondary lens fibre differentiation. However, studies also show that FGF signalling is not sufficient and roles have been identified for transforming growth factor-b and Wnt/Frizzled families in regulating aspects of fibre differentiation. In the case of the epithelium, key roles for Wnt/b-catenin and Notch signalling have been demonstrated in embryonic development, but it is not known if other factors are required for its formation and maintenance. This review provides an overview of current knowledge about growth factor regulation of differentiation and maintenance of lens cells. It also highlights areas that warrant future study.

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“…Mice lacking Fgfr4 appear to have normal lenses (Weinstein et al, 1998). Figure 2 summarizes the relative distribution of the mRNAs encoding each of the FGF receptors that are known to be expressed in the embryonic lens (Matsuo, 1993;de Iongh et al, 1996de Iongh et al, , 1997. Each receptor is present to some degree in the lens epithelium, the site of cell proliferation, and at the lens equator, where fiber cell differentiation is initiated.…”

Section: Introductionmentioning

confidence: 99%

Signaling through FGF receptor‐2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation

Garcia

Zhao³

et al. 2005

Developmental Dynamics

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Fibroblast growth factors (FGFs) play important roles in many aspects of development, including lens development. The lens is derived from the surface ectoderm and consists of an anterior layer of epithelial cells and elongated, terminally differentiated fiber cells that form the bulk of the tissue. FGF signaling has been implicated in lens induction, proliferation, and differentiation. To address the role of FGFs in lens development, we inactivated FGF receptor-2 (Fgfr2) using a Cre transgene that is expressed in all prospective lens cells from embryonic day 9.0. Inactivation of Fgfr2 shows that signaling through this receptor is not required for lens induction or for the proliferation of lens epithelial cells. However, Fgfr2 signaling is needed to drive lens fiber cells out of the cell cycle during their terminal differentiation. It also contributes to the normal elongation of primary lens fiber cells and to the survival of lens epithelial cells.

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FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth

Cited by 46 publications

References 41 publications

Lens differentiation and crystallin regulation: a chick model

Lens differentiation and crystallin regulation: a chick model

Understanding the role of growth factors in embryonic development: insights from the lens

Signaling through FGF receptor‐2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation

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