FGF-2 signaling activation in the hippocampus contributes to the behavioral and cellular responses to puerarin

Cheng, Jie; Chen, Min; Zhu, Ji-Xiao; Li, Cheng-Fu; Zhang, Qiuping; Geng, Di; Liu, Qing; Yi, Long

doi:10.1016/j.bcp.2019.06.025

Cited by 26 publications

(28 citation statements)

References 34 publications

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“… Adult stress CUMS FST ↑ Immobility time. ↑ Number Iba-1+ mRNA expression and protein levels: ↑ IL-1β ↑ IL-6 ↑ TNF-α – – ↓ DCX+ Cheng et al (2019) SPT ↓ Sucrose intake. CUMS Coat State Score ↓ State of the coat (↑ score).…”

Section: Resultsmentioning

confidence: 99%

“…Consistently, in adults, chronic stress reduced the preference for sucrose, indicating anhedonia. Thus, CUMS ( Cheng et al, 2019 ; Kim et al, 2016 ; Kreisel et al, 2014 ; Lu et al, 2014 ; Rimmerman et al, 2017 ; Vega-Rivera et al, 2020 ; Zhang et al, 2017 ; Zhong et al, 2019 ), chronic social defeat stress ( Jiang et al, 2020 ) and chronic water immersion restraint stress ( Mao et al, 2020 ) reduced sucrose intake. CUMS also induced deterioration of the coat ( Farooq et al, 2018 ; Vega-Rivera et al, 2020 ) and resulted in deficits in the ability of mice to make nests ( Farooq et al, 2018 ) and reduced body weight ( Lu et al, 2014 ; Zhang et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

“…Animals subjected to chronic stress tended to spend more time immobile than controls in classical tests that assess stress coping behaviour. In this regard, animals summited to CUMS ( Cheng et al, 2019 ; Kreisel et al, 2014 ; Lee et al, 2019 ; Lu et al, 2014 ; Vega-Rivera et al, 2020 ; Zhang et al, 2017 ; Zhong et al, 2019 ) or chronic social defeat stress ( Jiang et al, 2020 ) exhibited passive coping strategies in response to inescapable stressors in the FST, TST or both tests.…”

Section: Resultsmentioning

confidence: 99%

“…CUMS decreased the total number of DCX + cells ( Cheng et al, 2019 ; Lu et al, 2014 ; Rimmerman et al, 2017 ; Vega-Rivera et al, 2020 ; Zang et al, 2017 ; Zhong et al, 2019 ), which is considered indicative of the number of neural progenitor cells ( Zhong et al, 2019 ). Moreover, CUMS reduced the expression of β-tubulin III in the GCL and hilar SGZ margin ( Lu et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

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Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models

Nieto-Quero

Chaves-Peña

Santín

et al. 2021

Neurobiology of Stress

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Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The hippocampus is a target structure of the adverse effects of stress, and hippocampal neurogenesis plays a crucial role. However, we do not know the mechanisms by which stress impacts neurogenesis. Recent studies indicate that changes in neuroinflammation, primarily via microglial cells, may play an essential role in this process. However, the relationship between stress, microglial changes, and alterations in neurogenesis and their involvement in the development of depression is poorly characterized. For this reason, this systematic review aims to synthesise and evaluate current studies that have investigated the relationship between these variables. Taken together, the revised data, although not entirely conclusive, seem to suggest that microglial changes induced by psychological stress regulate neurogenesis and in turn may be responsible for the development of depressive-like behaviours, but other factors that influence these stressful experiences should not be dismissed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models

Nieto-Quero

Chaves-Peña

Santín

et al. 2021

Neurobiology of Stress

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“…Puerarin (100 mg/kg/day) attenuated depression-like behavior in OVX mice by decreasing the immobility times of the TST and FST [28]. Puerarin decreased the immobility time of FST in chronic stress mice [60]. The EPM is used to assess anxiety-like behavior in rodents [61], as presented in Figure 4C.…”

Section: Effect Of Lepe On Improving Menopause-related Depression Based On Behavioral Tests and Blood Hormone Levelsmentioning

confidence: 99%

Combined Extract of Leonurus japonicus Houtt, Eclipta prostrata L., and Pueraria lobata Ohwi Improved Hot Flashes and Depression in an Ovariectomized Rat Model of Menopause

Kang

Kim

Jung

et al. 2021

Foods

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Menopause leads to ovarian hormone loss, which causes symptoms such as weight gain, hot flashes, and depression. Exploring nutraceuticals is important for treating menopausal symptoms that extensively impact women’s quality of life. We hypothesized that a combination of Leonurus japonicus Houtt, Eclipta prostrata L., and Pueraria lobata Ohwi (LEPE) would alleviate menopausal symptoms in an ovariectomized menopausal rat model. Bilateral ovariectomy was performed and animals were assigned to five groups: (1) Sham, (2) Vehicle, (-) Control, (3) LEPE (100 mg/kg bw), (4) LEPE (200 mg/kg bw), and (5) Estradiol (3 μg/kg bw). LEPE was orally administered daily for 12 weeks. LEPE supplementation did not affect growth performance (body weight and feed intake) or body composition (lean mass and fat in tissue). LEPE did not cause deviations in aspartate aminotransferase, alanine aminotransferase, estradiol, and follicle-stimulating hormone levels, indicating no hepatotoxicity or endocrine disturbance. LEPE decreased type I collagen (CTX-1) but did not affect bone mineral density or osteocalcin. LEPE decreased tail temperature and increased rectal temperature, improving menopause-related vasomotor symptoms. Furthermore, LEPE ameliorated depression-related behavior, including in forced swimming and tail suspension tests. Thus, LEPE may improve menopausal symptoms by enhancing vasomotor symptoms and depression in an ovariectomized rat menopause model.

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Optimization of the Zhou Tian Formula extraction technology based on AHP‐CRITIC method and analysis of transfer efficiency of key components based on HPLC fingerprinting

Ma,

Feng,

Yao

et al. 2024

Phytochemical Analysis

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IntroductionZhou Tian Formula (ZTF) is an antidepressant traditional Chinese medicine utilized widely in clinical settings for the treatment of patients with depression. However, shortcomings persist in its extraction technology and quality control.ObjectiveThis study aimed to propose a methodology for ZTF extraction technology based on the analytic hierarchy process (AHP)–criteria importance through intercriteria correlation (CRITIC) method and to establish a quality control framework for the efficient transfer of index components.MethodFirstly, we analyzed the chemical components of ZTF and determined the optimal extraction technology. Secondly, we calculated the transfer efficiency of the index components during the conversion of water decoction to extract powder and subsequently to granules. Thirdly, we established HPLC fingerprints for 15 batches of ZTF water decoction, extract powder, and granules. We employed SIMCA software to analyze the chemicals responsible for variations in quality among different batches of ZTF granules.ResultsWe determined the optimal extraction process. The average transfer efficiency of ferulic acid, puerarin, mirificin, isoferulic acid, and calycosin during the conversion of water decoction to extract powder and subsequently to granules exceeded 41%. The HPLC fingerprints of ZTF exhibited a similarity exceeding 0.890. Variable importance in projection values indicated that calycosin, ferulic acid, and puerarin were the primary contributors to quality variations.ConclusionsThe AHP‐CRITIC method, coupled with an orthogonal array design, could be used for exploring extraction technology. In addition, the rules governing the transfer of index components from water decoction to extract powder, and subsequently to granules, could be applied for the evaluation and quality assessment of ZTF.

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FGF-2 signaling activation in the hippocampus contributes to the behavioral and cellular responses to puerarin

Cited by 26 publications

References 34 publications

Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models

Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models

Combined Extract of Leonurus japonicus Houtt, Eclipta prostrata L., and Pueraria lobata Ohwi Improved Hot Flashes and Depression in an Ovariectomized Rat Model of Menopause

Optimization of the Zhou Tian Formula extraction technology based on AHP‐CRITIC method and analysis of transfer efficiency of key components based on HPLC fingerprinting

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