2010
DOI: 10.1152/ajplung.00070.2010
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FGF-1 reverts epithelial-mesenchymal transition induced by TGF-β1 through MAPK/ERK kinase pathway

Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by the expansion of the fibroblast/myofibroblast population and aberrant remodeling. However, the origin of mesenchymal cells in this disorder is still under debate. Recent evidence indicates that epithelial-mesenchymal transition (EMT) induced primarily by TGF-beta1 plays an important role; however, studies regarding the opposite process, mesenchymal-epithelial transition, are scanty. We have previously shown that fibro… Show more

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Cited by 122 publications
(124 citation statements)
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“…Furthermore, TGFb-stimulated increases in IL-6 concentrations, which are dependent on Smad2/3 signaling (37), were also not attenuated by FGF-2. In contrast to our observations in ASM cells, FGF-2 (or FGF-1) inhibits TGF-b-stimulated Smad 2/3 phosphorylation in aortic interstitial valvular cells (38) and in alveolar epithelial-like cell lines (20). However, TGF-b-stimulated Smad2/3 phosphorylation in nucleus pulposus cells is not attenuated by FGF-2 (39).…”
Section: Discussioncontrasting
confidence: 93%
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“…Furthermore, TGFb-stimulated increases in IL-6 concentrations, which are dependent on Smad2/3 signaling (37), were also not attenuated by FGF-2. In contrast to our observations in ASM cells, FGF-2 (or FGF-1) inhibits TGF-b-stimulated Smad 2/3 phosphorylation in aortic interstitial valvular cells (38) and in alveolar epithelial-like cell lines (20). However, TGF-b-stimulated Smad2/3 phosphorylation in nucleus pulposus cells is not attenuated by FGF-2 (39).…”
Section: Discussioncontrasting
confidence: 93%
“…Similarly, acidic FGF (FGF-1) inhibits the differentiation (and transdifferentiation) of lung epithelial cells and fibroblasts into myofibroblasts (20,21). Although FGF-2 is a potent mitogen of ASM cells (16), the lack of antagonism of TGF-b-stimulated contractile protein gene expression and organization by the powerful mitogens thrombin and FCS is not consistent with the idea that the antagonism of TGF-b's effects is secondary to mitogenic signaling.…”
Section: Discussionmentioning
confidence: 99%
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“…Furthermore, TGF-β and FGF-2 might cooperate with each other and regulate the EMT of various types of cells in microenvironments during cancer progression (18,37). However, there have been contrary reports, including results that suggest that TGF-β1-induced EMT is reversed by FGF-1 in IPF (19).…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, some studies have led to a different conclusion. For example, FGF-1 was found to display antifibrotic functions by downregulating collagen expression and antagonizing some of the profibrotic effects of TGF-β (7,16,19).…”
Section: Introductionmentioning
confidence: 99%