FFP:RBC Resuscitation Ratio and Post-Shock Fluid Uptake

Lucas, Charles E.; Ledgerwood, Anna M.

doi:10.1001/jamasurg.2013.623

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…The major adverse effects of CLS include alveolar edema, restricted gas exchange and hypoxia, all of which aggravate injuries to the capillary endothelium cause edema in major organs such as the brain, the heart, the liver and the kidneys with the structures and functions that are damaged and that ultimately result in multiple organ dysfunction syndromes (MODS). Once that happens, the patient’s condition becomes more serious and includes higher risk for death [7]. Therefore, investigating the pathogenesis of vascular leakage or increased capillary permeability is of great significance for the prophylaxis and treatment of CLS.…”

Section: Introductionmentioning

confidence: 99%

Regulatory mechanisms, prophylaxis and treatment of vascular leakage following severe trauma and shock

Duan

Zhang

et al. 2017

Military Med Res

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Vascular leakage, or increased vascular permeability, is a common but important pathological process for various critical diseases, including severe trauma, shock, sepsis, and multiple organ dysfunction syndrome (MODS), and has become one of the most important causes of death for intensive care units (ICU) patients. Currently, although there has been some progress in knowledge of the pathogenesis of these vascular disorders, the detailed mechanisms remain unclear, and effective prophylaxis and treatment are still lacking. In this study, we aimed to provide a review of the literature regarding the regulatory mechanisms and prophylaxis as well as the treatment of vascular leakage in critical diseases such as severe trauma and shock, which could be beneficial for the overall clinical treatment of vascular leakage disorders.

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Section: Introductionmentioning

confidence: 99%

Regulatory mechanisms, prophylaxis and treatment of vascular leakage following severe trauma and shock

Duan

Zhang

et al. 2017

Military Med Res

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“…Similarly, in the abdomen, it aggravates retroperitoneal edema and ascites that raise intra-abdominal pressure which is the major cause of death in ACS. [ 1 , 8 , 11 ] In our case, the intravenously infused crystalloid volume (approximately 4500 mL before surgery) was not enough to cause fatal pulmonary edema and ACS. Studies have shown that the administration of more than 5000 mL of crystalloid within 24 h is one of the independent risk factors for secondary ACS, and more than 7000 mL of crystalloid increases the risk of fatal pulmonary edema.…”

Section: Discussionmentioning

confidence: 67%

Trauma induced capillary leak syndrome after penetrating chest injury: Manifestation of massive ascites and pulmonary secretions aggravated by transfusion

Youn¹

2020

Ulus Travma Acil Cerrahi Derg

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Trauma with prolonged shock can cause systemic capillary leak syndrome regardless of the site of injury and a transfusion can aggravate it. The systemic capillary leak induces both an abdominal compartment syndrome and pulmonary edema, and a transfusion can aggravate these sequelae within hours. In our case, 21-year-old man with a penetrating injury in his left thorax experienced delay in rescue and definitive surgery. To manage life-threatening shock, massive blood transfusion and crystalloids had been infused. Cardiopulmonary cerebral resuscitations were performed 2 times during the surgery. Massive amount of pulmonary secretions emitted from his airways with severe hypoxia along with development of massive ascites causing abdominal compartment syndrome, while the surgery was underway. After temporary abdominal closure, he was moved to the intensive care unit and underwent venovenous extracorporeal membranous oxygenation. He recovered without any notable complications. It is important to prevent and correct the shock rapidly by appropriate rescue, controlling the source and infusing less amount of crystalloid and transfusion.

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“…Sepsis can increase cell permeability, and lead to capillary leakage syndrome (CLS), which causes severe hypoproteinemia, hypovolemia, tissue hypoperfusion, edema, shock and multiple organ dysfunction syndrome [22][23][24]. Our previous studies have shown that TH can improve the permeability of septic cells [7].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Hypothermia Mitigates the Sepsis-Increased Permeability in EA. hy926 Cells by Preserving Rap1 Expression

Shen

Ding

2021

Therapeutic Hypothermia and Temperature Management

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Background: To determine the effect and potential mechanisms of therapeutic hypothermia (TH) on the permeability of septic cells.Main methods: Human EA. hy926 cells were transfected with, or without, control or Rap1-speci c siRNA and treated with 2 µg/ml of lipopolysaccharide (LPS), followed by cultured in normal temperature (NT) or a temporary therapeutic hypothermia (TH) for 10 h. The cellular permeability of each group of cells was determined by transwell permeability assay and the relative levels of ras-proximate-1 (Rap1), RhoA (a small GTP enzyme of the Rho family), Ve-cadherin expression and myosin light chain (MLC) phosphorylation were quanti ed by western blot and immuno uorescent assays.Results: Compared with the control group, LPS stimulation increased cellular permeability, which was enhanced by Rap1 silencing in EA. hy926 cells under a NT condition, but signi cantly mitigated by TH. Furthermore, LPS up-regulated RhoA expression and MLC phosphorylation, but reduced Rap1 and Vecadherin expression, which were also enhanced by Rap1 silencing, but signi cantly mitigated by TH.

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FFP:RBC Resuscitation Ratio and Post-Shock Fluid Uptake

Cited by 5 publications

References 29 publications

Regulatory mechanisms, prophylaxis and treatment of vascular leakage following severe trauma and shock

Regulatory mechanisms, prophylaxis and treatment of vascular leakage following severe trauma and shock

Trauma induced capillary leak syndrome after penetrating chest injury: Manifestation of massive ascites and pulmonary secretions aggravated by transfusion

Therapeutic Hypothermia Mitigates the Sepsis-Increased Permeability in EA. hy926 Cells by Preserving Rap1 Expression

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