Abstract:Methods Patients with histologically confirmed H-SIL and/or VIN 2-3 will be treated with Pembrolizumab 200 mg flat dose every 3 weeks for 5 cycles. Within 4 weeks from the last Pembrolizumab administration patients will be submitted to surgical conization (either cold knife conization or LEEP) and/or partial or radical vulvectomy. During the screening phase patients will receive blood and stool specimen's collection. Genotyping for HPV will be performed at baseline, surgery and at safety follow up visit. Resul… Show more
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