Fever of unknown origin in 185 paediatric patients: A single-centre experience

Pasic, Srdjan; Minic, Aleksandra; Djuric, Predrag; Mićić, Dragan; Kuzmanović, Miloš; Sarjanovic, Ljudmila; Marković, Milanka

doi:10.1080/08035250500437549

Cited by 40 publications

(18 citation statements)

References 10 publications

(8 reference statements)

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“…CMV, HHV-6, and EBV were the viruses detected most commonly in FUO patients. The prevalence, co-infection, and clinical profiles in this study were consistent with similar studies of paediatric FUO patients [9], [13], [14]. Based on the data, our study clearly indicates an association between individual HHV infection and the clinical signs of FUO, which might be clinically important for diagnosis and treatment in the future.…”

Section: Discussionsupporting

confidence: 90%

“…The issue of FUO in paediatrics is hazy and represents a challenging diagnostic dilemma [5]. Presently, FUO cases are codified in four subclasses [6], [7]: classic, nosocomial, immune-deficient, and human immunodeficiency virus (HIV)-associated FUO. Infection is by far the most commonly identified aetiology of FUO in all paediatric studies [7], [8], including bacterial infections, brucellosis, tuberculosis, and typhoid fever.…”

Section: Introductionmentioning

confidence: 99%

“…Comparing developed and developing nations, infection is consistently the most common cause of FUO, but the types of infection vary [10]–[15]. Viral aetiologies for FUO are more common in developed countries [7], [13], particularly Epstein–Barr virus (EBV). It is disappointing that long-term outcome data are not available for the large number of children for whom no diagnosis for their FUO is established [7], [15].…”

Section: Introductionmentioning

confidence: 99%

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Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients

Zhou

Tan²,

et al. 2014

PLoS ONE

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BackgroundFew reports have examined the viral aetiology of fever of unknown origin (FUO).ObjectiveThis study determined the prevalence of human herpes virus (HHV) DNA in blood of Chinese patients with classic FUO using the polymerase chain reaction (PCR) and explored the possible role of HHV.Study designBlood samples were collected from 186 patients (151 children, 35 adults) with classic FUO and 143 normal individuals in Beijing during the years 2009–2012. The HHV DNA, including Herpes simplex virus (HSV)-1/2, Varicella zoster virus (VZV), Cytomegalovirus (CMV), Epstein–Barr virus (EBV), and Human herpes virus (HHV)-6 and -7, was detected by multiplex PCR. The epidemiological and clinical features were also analysed.ResultsHHV DNA was detected in 63 (33.9%) of the FUO patients, and the prevalence of EBV and HHV-6 was significantly higher than in the normal cohort. HHV co-infection was also frequent (10.2%) in the patients with FUO. The majority of patients with HHV infection present with a fever only. Our data also revealed that EBV infection was associated with hepatitis and abnormal blood indices, HHV-6 was associated with a cough, and HHV-7 was associated with hepatitis.ConclusionsHHVs are associated with Chinese patients (especially for children) with classic FUO. Our study adds perspective to the aetiological and clinical characteristics of classic FUO in beijing patients.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients

Zhou

Tan²,

et al. 2014

PLoS ONE

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“…Overall, the paediatric population demonstrates infections as the predominant disease category. 2,3,7,[9][10][11][12][13][14][15][16][17][18][19][20][21] This might be owing to selection of patients, especially in developed countries where infectious causes of PUO are less common. An exception to this is the series by Dechovitz & Moffet in which collagen vascular diseases outnumbered infectious cases by a significant majority.…”

Section: Discussionmentioning

confidence: 99%

Clinical spectrum of fever of unknown origin among Indian children

Joshi

Rajeshwari

Dubey

et al. 2008

Annals of Tropical Paediatrics

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“…After an exhaustive study, in 10-32% of cases, according to geographic location, no etiology is determined [2][3][4][5][6][7][8][9] . It should be mentioned that identifying the etiological diagnosis can be complex, due to atypical presentations of frequent clinical pictures [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

Paniculitis como manifestación de síndrome febril prolongado en pediatría: Caso clínico

Silva

Radrigán

Lafuente

et al. 2017

Rev. chil. pediatr.

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Introduction: Fever of unknown origin (FUO) is defined as fever over 7 to 10 days without a diagnosis despite a complete initial study. The most frequent causes are infections, autoimmune and tumors. Even though most cases are self-limited there is a minority that has an underlying etiology with an ominous forecast, encouraging a systematized study. Objective: To report a rare case of a boy who presented fever of unknown origin associated to panniculitis and was diagnosed of subcutaneous panniculitis-like-T cell lymphoma and to emphasis the importance of a sequential study of FUO, in order to reach a diagnosis in patients who need a timely intervention. Clinical case: A ten year old boy, previously healthy, presented subcutaneous nodular lesions of 2 month of evolution, located in abdominal region and extremities, given few symptoms, associated with prolonged fever. He was hospitalized for proper study, in first instance infectious and immune causes were discarded and through lesions biopsy the diagnose of subcutaneous panniculitis-like-T cell lymphoma was reached. Conclusion: When FUO is diagnosed, most prevalent causes must be discarded. Then, differential diagnosis, such as immune and neoplasic etiologies, have to be considered. If FUO is associated to elemental nodular lesions, biopsy must be indicated early, in order to find potential malignant cases, avoiding therapeutic delay.

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Fever of unknown origin in 185 paediatric patients: A single-centre experience

Cited by 40 publications

References 10 publications

Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients

Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients

Clinical spectrum of fever of unknown origin among Indian children

Paniculitis como manifestación de síndrome febril prolongado en pediatría: Caso clínico

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