Fever of Unknown Origin

Mackowiak, Philip A.; Durack, David T.

doi:10.1016/b978-0-443-06839-3.00051-5

Cited by 14 publications

(11 citation statements)

References 90 publications

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“…Fever of unknown origin continues to be a complicated problem since its diagnosis depends on geographical regions, socioeconomic conditions and the experience of the clinicians evaluating the patient. Another reason further complicating the diagnosis is the lack of a generally accepted diagnostic algorithm in spite of the developments in the diagnostic methods 3,4,6 . In developing and developed countries, the most common cause of the fever of unknown origin is infectious diseases.…”

Section: Discussionmentioning

confidence: 99%

“…The underlying cause of fever of unknown origin is generally investigated in 5 categories as infectious diseases, malignant conditions, collagen vascular diseases, miscellaneous diseases and undiagnosed etiology. The frequency of these diseases varies according to the geographical region, age group and socio-economic conditions 4 . Infectious diseases and collagen vascular diseases are the most frequently revealed disease groups in the etiology of fever of unknown origin 5 .…”

Section: Introductionmentioning

confidence: 99%

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Nedeni bilinmeyen ateş: 30 çocuk hastanın değerlendirilmesi

Gündeşli̇oğlu

Kocabaş

Alhan³

et al. 2019

Cukurova Medical Journal

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The aim of this retrospective study is to evaluate the etiology clinical and laboratory features of fever of unknown origin (FUO) diagnosed in 30 pediatric patients. Materials and Methods: The clinical data including the etiology, diagnostic approaches and clinical characteristics were retrospectively analysed in 30 pediatric patients with FUO who presented to our clinic in oneyear period. Results: The median age of the patients was 63 (6-192) months. Among the patients, 12 were male (40%), while 18 were female (60%). The median duration of the fever was 22.5 (3-60) days during hospital admission. The most common physical findings were hepatomegaly and splenomegaly, which were observed in 53. 3 and 40 patients, respectively. The cause of the FUO was detected to be infection in 14 patients (46.6%), connective tissuevascular diseases in 8 patients (26.7%), malignancies in 5 patients (16.7%), and miscellaneous diseases in 1 patient (3.3%). In two patients (6.6%) the etiology could not be identified. Leishmaniasis, tuberculosis and Brucellosis were the most commonly identified infections, whereas juvenile rheumatoid arthritis and acute lymphoblastic leukemia were the most common non-infectious causes. Conclusion: The most common cause of FUO in our study was infection diseases. Connective-vascular tissue diseases and malignancies are also important causes of FUO. In our opinion, detailed patient history, carefully physical examination and close clinical follow-up may reduce the number of the invasive procedures and noninvasive tests.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nedeni bilinmeyen ateş: 30 çocuk hastanın değerlendirilmesi

Gündeşli̇oğlu

Kocabaş

Alhan³

et al. 2019

Cukurova Medical Journal

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“…In up to 30% of cases no diagnosis is ever established. 88,89 Two long-term studies were conducted on children in whom an extensive workup yielded no diagnosis. One study showed resolution without contributory diagnosis in 17 of the 19 patients, with 2 eventually diagnosed with juvenile rheumatoid arthritis.…”

Section: Fever Of Unknown Originmentioning

confidence: 99%

Pediatric Emergencies Associated with Fever

Claudius¹,

Baraff²

2010

Emergency Medicine Clinics of North America

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“…Metal fume fever is included in miscellaneous disorders [1]. The fumes or gases are a form of several metals, for example cadmium (Cd), manganese (Mn), mercury (Hg), and zinc chloride (ZnCl2).…”

Section: Introductionmentioning

confidence: 99%

Acute mercury poisoning presenting as fever of unknown origin in an adult woman: a case report

et al. 2014

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IntroductionMercury intoxication may present in a wide range of clinical forms from a simple disease to fatal poisoning. This article presents a case of acute mercury poisoning, a rare condition that presents challenges for diagnosis with fever of unknown origin.Case presentationA 52-year-old Caucasian woman was admitted to the hospital with high fever, sore throat, a rash over her entire body, itching, nausea, and extensive muscle pain. She had cervical, bilateral axillary and mediastinal lymphadenopathies. We learned that her son and husband had similar symptoms. After excluding infectious pathologies, autoimmune diseases and malignancy were investigated. Multiple organs of our patient were involved and her fever persisted at the fourth week of admission. A repeat medical history elicited that her son had brought mercury home from school and put it on the hot stove, and the family had been exposed to the fumes for a long period of time. Our patient’s serum and urine mercury levels were high. She was diagnosed with mercury poisoning and treated accordingly.ConclusionsMercury vapor is a colourless and odorless substance. Therefore, patients with various unexplained symptoms and clinical conditions should be questioned about possible exposure to mercury.

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Fever of Unknown Origin

Cited by 14 publications

References 90 publications

Nedeni bilinmeyen ateş: 30 çocuk hastanın değerlendirilmesi

Nedeni bilinmeyen ateş: 30 çocuk hastanın değerlendirilmesi

Pediatric Emergencies Associated with Fever

Acute mercury poisoning presenting as fever of unknown origin in an adult woman: a case report

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