Fever and Rash in a Patient With Hepatitis

Clement, Meredith E.; Okeke, Nwora Lance; Hicks, Charles B.

doi:10.1001/jama.2015.3401

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…The broadspectrum antibiotics must be initiated promptly since clinical deterioration can occur over hours. Antibiotic administration should not be delayed by a diagnostic work-up (Clement et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Human Babesiosis : A General Review with Special Reference to Egypt

Saleh

Adam

Abdel-Motagaly

et al. 2015

JESP

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Babesiosis is a tick-borne malaria-like illness caused by species of the intra-erythrocytic protozoan Babesia. Humans are opportunistic hosts for Babesia when bitten by nymph or adult ticks. Currently, Babesia infection is transmitted by various tick vectors in Europe, Asia, Africa and the northwestern and northeastern United States. Human babesiosis was first described in 1957 but is now known to have worldwide distribution. The increase in reported cases is likely due to increases in actual incidence as well as increased awareness of the disease. Despite the diagnostic and preventive advances resulting from extensive research and a greater understanding of the disease, babesiosis continues to have significant medical impact as a confounding variable in the diagnosis and treatment of Lyme disease and as a potential threat to the blood supply, especially in the United States. Diagnostic advances, like the development of PCR assays, have resulted in increased sensitivity for detection as well as the discovery and characterization of new babesial species. Further studies using the molecular tools now available and those to be developed will lead to a better understanding of the natural history of these organisms, including the transmission cycle and the potential role of Babesia parasites themselves as immunomodulator. Human babesiosis is usually an asymptomatic infection in healthy individuals. Several patients become symptomatic, and, within these subpopulations, significant morbidity and mortality occur, especially in elderly, immunocompromised, or asplenic patients. It is difficult to diagnose. Although the index of suspicion should be high in rural Babesia endemic areas, patients with babesiosis have few, if any, localizing signs to suggest the disease. Diagnosis confirmation depends on the parasitemia degree, the expertise and well trained laboratory personnel. Most patients infected by B microti who are otherwise healthy appear to have a mild illness and typically recover without specific chemotherapy; however, treatment is recommended for all diagnosed cases to prevent sequelae and potential transmission through blood donation. In addition, patients should be advised to take precautions against tick exposure and to refrain from donating blood until completely cured of babesiosis.

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Section: Introductionmentioning

confidence: 99%

Human Babesiosis : A General Review with Special Reference to Egypt

Saleh

Adam

Abdel-Motagaly

et al. 2015

JESP

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A Systematic Literature Review of Syphilitic Hepatitis in Adults

Huang¹,

Lin²,

Wan³

et al. 2018

Journal of Clinical and Translational Hepatology

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Syphilitic hepatitis in adults is not frequently found in the population and is easily misdiagnosed. The incidence of viral hepatitis is increasing year by year, concomitantly increasing the importance of obtaining a systematic understanding of the clinical features and treatment strategies for this disease. There is, however, a lack of published definitive data regarding the clinical characteristics, diagnosis and standard treatment options for this disease. Searches were made using the MEDLINE database of PubMed and OVID for syphilitic hepatitis publications from 1951 to 2017 in an attempt to analyze and summarize the clinical characteristics.

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Fever and Rash in a Patient With Hepatitis

Cited by 2 publications

References 8 publications

Human Babesiosis : A General Review with Special Reference to Egypt

Human Babesiosis : A General Review with Special Reference to Egypt

A Systematic Literature Review of Syphilitic Hepatitis in Adults

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