Fever and pneumonitis induced by enteric-coated mycophenolate sodium in a patient after kidney transplantation

Abstract

Summary Here, we report on a patient after kidney transplantation, who developed fever and pneumonitis due to mycophenolic acid (MPA) treatment. Decreasing MPA dosages improved the symptoms, but after rechallenge with higher MPA doses the symptoms recurred. Discontinuation of MPA resulted in a complete resolution of fever within 24 h and a rapid improvement in pneumonitis. In vitro, the patient's polymorphonuclear neutrophils (PMNs) developed increased oxidative burst when incubated with MPA and N‐formyl Met‐Leu‐Phe. We first report on MPA‐induced pneumonitis and show that MPA can induce a pro‐inflammatory response in kidney‐transplanted patients. These pro‐inflammatory changes might be due to paradoxical activation of PMNs.

Mycophenolate Mofetil (Cellcept) Induced Pneumonitis: Case Report and Review of Literature

“…DOI: 10.51542/ijscia.v2i5.9Cases of Mycophenolate induced pneumonitis have been previously reported, but extensive clinical trials and research accessing its incidence are currently unreported (Pocivalnik et al, 2013, Gross et al, 1997…”