Fever and Petechial Rash Associated with Parvovirus B19 Infection

Parvovirus B19-associated purpuric–petechial eruption

“…Six cases were reported with prominent acral and intertriginous distribution. 5,[11][12][13][14] In contrast, generalized purpuric-petechial papules of our case 2 were concentrated in the trunk and the intertriginous areas without acral involvement. One PVB19 infected case showed purpuric-petechial papules with a baboon syndrome-like distribution that resembled our case 2.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][18][19][20][21][22][23] In contrast to EI seen in the post-viremic phase, 24 purpuric-petechial eruptions are closely linked to the viremic phase of primary PVB19 infection. [2][3][4][5][6]8,[11][12][13][14][15][16][18][19][20][21][22] Therefore, patients with papular-purpuric eruptions caused by PVB19 are considered infectious when presenting with the rash. 24 The most common histopathologic finding of these purpuric-petechial eruptions is an inflammatory perivascular lymphocytic infiltrate with extravasated erythrocytes in the dermis.…”

Parvovirus B19–Associated Microvesicular Eruption

“…This infection usually causes erythema infectiosum, a benign self‐limiting disease characterized by typical cutaneous manifestations (slapped cheek appearance followed by a diffuse maculopapular rash evolving to a reticular pattern). Focal acral petechial eruption (papular purpuric gloves and socks syndrome) and other cutaneous hemorrhagic manifestations have also been reported . We describe an unusual pediatric case of parvovirus B19 infection associated with a generalized microvesicular eruption.…”

Clinical Characteristics of Human Parvovirus B19 Infection in Children

“…1) This infection usually causes erythema infectiosum, also known as fifth disease, a benign self-limiting disease characterized by typical cutaneous manifestations. 2) In addition to erythema infectiosum, acute infection with parvovirus B19 can be associated with purpuric or petechial rashes, often with focal acral petechial eruption, referred to as papular-purpuric "gloves-and-socks" syndrome. 3) A few reports have described generalized petechial rashes associated with parvovirus B19 infection.…”