Fever and High C-reactive Protein Level as the Sole Manifestation of Allergy to Cow Milk

Creatine kinase and C reactive protein as an indicator for tissue damage in the retained placenta in cows

“…The result of current study showed that the number of previous calving associated with retained placenta didn't affect the serum concentration of CRP and CK in, in contrast, the previous parturition status will affect the frequencies of retained placenta occurrence, were it's with highest incidence in heifers and in cows characterized by small size of both external genital organs and pelvic bones (23). The results of current study indicate that the increasing of time that consumed to expel placenta were significantly related to increase in concentration of CRP and CK in serum, this will be associated with cellular damages that lead to increase in serum concentration of CRP and CK in cows (14,15).…”

“…Also, CK concentration level in serum of cow suffering from retained placenta was increased due to placenta cellular damages lead to releasing these biochemical components into the bloodstream, in which uterus and placenta were rich with CK as a source to reversible energy-saving (15). The serum concentration of CRP and CK in cows with retained placenta didn't affect with the sex of calves, in which the concentration of CRP and CK in serum showed no significant difference, in contrast, the serum concentration of CRP and CK in cows suffering from retained placenta with calves either male and females were significantly higher than that recorded in a cow with male and female calves with normal parturition, this indicates that the sex of calves didn't have any effect on the concentration of these biochemical molecules from cows suffering from the retained placenta (14,15). The concentration of CRP in serum of pregnant and parturiated cows affect mainly with infectious diseases especially ischemia, inflammation and cell injury (16), while the concentration of CK increase in cases hypocalcemia, muscle damages, and endometritis (17,18), the effect of high serum concentration of CRP and CK in in cows with retained placenta can lead to prevent or decrease transportation of immunoglobulins from dams to their calves through colostrum significantly when the concentration of CK were increased in blood serum (19), these high level of CK in blood serum will cause increase in cortisol secretion in bloodstream which lead to decrease in immunoglobulins formation and secretions (20), also increase CRP concentration in blood serum will prevent transportation of immunoglobulin from dams to calves through colostrum, these mechanism conducted by CRP to act as opsonic elements which bind to Fc receptors and prevent transport immunoglobulins to calves through colostrum which is the main side effect of high serum concentrations of CRP and CK in case of retained placenta in animals (21,22).…”

“…These results agreed with other studies that indicate that most common squealy and complications of retention of fetal membranes as endometritis, mastitis and paralysis (11)(12)(13). Endometritis and mastitis associated with retained placenta will cause an increase in the level of acute-phase protein especially CRP which increase in response to increase in IL-6 secretion from macrophages and lymphocytes in the retained placenta, the rise in CRP secretions will bind to specific molecules on dying cell surface of apoptotic cells to facilitate and assist macrophages to phagocytosis these affect cells present in the placenta to decrease the risk of infection and inflammation that can be established in the placenta during retained placenta (14). Also, CK concentration level in serum of cow suffering from retained placenta was increased due to placenta cellular damages lead to releasing these biochemical components into the bloodstream, in which uterus and placenta were rich with CK as a source to reversible energy-saving (15).…”

The natural history of cow's milk allergy in north-eastern Poland

“…Rare clinical manifestations of cow's milk allergy in the form of behavioral or psychomotor disturbances were observed in a few patients after exposure to cow's milk. Also, milk-induced fever, a relatively rare symptom of allergy [37], was observed in five patients. All episodes of fever developed within 48 hours following commencement of the provocations and did subside directly after milk withdrawal.…”

“…All episodes of fever developed within 48 hours following commencement of the provocations and did subside directly after milk withdrawal. Fever, due to food allergy, is rarely taken into account and as such is easily overlooked [37][38][39][40]. Therefore, we suggest that body temperature could be considered in the list of symptoms routinely monitored during a food challenge.…”